Page last updated: 2024-12-07

cyclotriphosphazene ester

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Cyclotriphosphazene esters are a class of organophosphorus compounds derived from hexachlorocyclotriphosphazene (N3P3Cl6). They are synthesized through a multi-step process involving the reaction of hexachlorocyclotriphosphazene with alcohols or phenols in the presence of a base. These reactions replace the chlorine atoms with alkoxy or aryloxy groups, resulting in the formation of cyclotriphosphazene esters. Cyclotriphosphazene esters have garnered significant attention in various research fields due to their unique properties and potential applications. For instance, they exhibit high thermal stability, flame retardancy, and good dielectric properties. The presence of the phosphazene ring and the tunable nature of the alkoxy or aryloxy substituents allow for the fine-tuning of their physical and chemical properties. Cyclotriphosphazene esters have been investigated as flame retardants for polymers, additives for lubricants, and materials for optical and electronic applications. Research efforts are focused on understanding the structure-property relationships, exploring novel synthetic methodologies, and developing new applications for these versatile compounds.'

cyclotriphosphazene ester: hydraulic fluid [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

1,3,5,2,4,6-triazatriphosphinine : An inorganic heteromonocyclic compound that is 1,3,5-triazine in which the carbon atoms have been replaced by phosphorus atoms. It was one of a series of compounds which was being developed for use as a fire-resistant hydraulic fluid. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID120195
CHEBI ID167642
MeSH IDM0186680

Synonyms (10)

Synonym
1,3,5,2,4,6-triazatriphosphinine
CHEBI:167642
2,4,6-triphospha-1,3,5-triazine
291-37-2
phosphonitrile trimer
cyclotriphosphazene ester
cyclotriphosphazene
1,3,5,2,4,6-triazatriphosphorine
cyclotriphosphazatriene
DTXSID90183351

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" This study was designed to evaluate the toxic effects associated with repeated or continuous exposure to CTP by both dermal and inhalation routes."( Determination of the toxicity of cyclotriphosphazene hydraulic fluid by 21-day repeated inhalation and dermal exposure.
Grabau, J; Kimmel, E; Kinkead, E; Wall, H, 1990
)
0.28

Compound-Compound Interactions

ExcerptReferenceRelevance
"Derivatives of the tri-spirane pentaerythritoxy-cyclophosphazene compound, 1, have been used to investigate the stereogenic properties of spiranes combined with four equivalent conventional centres of chirality."( Stereogenic properties of spiranes combined with four equivalent conventional centres of chirality.
Coles, SJ; Davies, DB; Eaton, RJ; Hursthouse, MB; KiliƧ, A; Shaw, RA; Uslu, A, 2007
)
0.34
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (4)

ClassDescription
nitrogen molecular entity
phosphorus molecular entity
inorganic heteromonocyclic compound
inorganic aromatic compound
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (7.69)18.2507
2000's8 (61.54)29.6817
2010's3 (23.08)24.3611
2020's1 (7.69)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.04

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.04 (24.57)
Research Supply Index2.77 (2.92)
Research Growth Index4.81 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.04)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]