Compounds > cycloclavine
Page last updated: 2024-11-13

cycloclavine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

cycloclavine: isolated from the seeds of the African morning glory (Ipomea hildebrandtii): structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID24823847
SCHEMBL ID15828351
MeSH IDM0560403

Synonyms (10)

Synonym
cycloclavine
xrq6tj7kl8 ,
SCHEMBL15828351
Q15633927
1h-cycloprop[c]indolo[4,3-ef]indole, 1a,2,3,3a,4,6-hexahydro-1a,3-dimethyl-, (1ar,3ar,9br)-
(+)-cycloclavine
(8beta,10s)-6,8-dimethyl-8,10-cycloergoline
8,10-cycloergoline, 6,8-dimethyl-, (8beta,10s)-
(2s,4s,7r)-4,6-dimethyl-6,11-diazapentacyclo[7.6.1.02,4.02,7.012,16]hexadeca-1(16),9,12,14-tetraene
DTXSID701045769

Research Excerpts

Overview

Cycloclavine is a clavine-type Ergot alkaloid. It has a unique pentacyclic skeleton featuring a 3-azabicyclo[3.1.0]hexane substructure.

ExcerptReferenceRelevance
"Cycloclavine is a clavine-type Ergot alkaloid noteworthy for its unique pentacyclic skeleton featuring a 3-azabicyclo[3.1.0]hexane substructure. "( A Modular Formal Total Synthesis of (±)-Cycloclavine.
Netz, N; Opatz, T, 2016)		2.14
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's7 (100.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.01

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.01 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.01)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
acetaldehyde
Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.. acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.. aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.. acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.		2.110aldehydecarcinogenic agent;
EC 3.5.1.4 (amidase) inhibitor;
electron acceptor;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
mutagen;
oxidising agent;
Saccharomyces cerevisiae metabolite;
teratogenic agent
cyclopropane
cyclopropane : A cycloalkane composed of three carbon atoms to form a ring.		2.1110cycloalkane;
cyclopropanes		inhalation anaesthetic
2-methylpentane
Hexanes: Six-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Various polyneuropathies are caused by hexane poisoning.		2.1310alkane
n-hexane
hexane : An unbranched alkane containing six carbon atoms.		2.1310alkane;
volatile organic compound		neurotoxin;
non-polar solvent
rhodium
Rhodium: A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh.. rhodium atom : A cobalt group element atom of atomic number 45.		2.1710cobalt group element atom
alkenes
[no description available]		2.1710
3-azabicyclo(3.1.0)hexane
3-azabicyclo(3.1.0)hexane: structure in first source		2.1310
ConditionIndicatedRelationship StrengthStudiesTrials