Compounds > cucurbitacin iib

Page last updated: 2024-11-12

cucurbitacin iib

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

cucurbitacin IIb: has anti-inflammatory activity; isolated from Hemsleya amabilis; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Hemsleya	genus	[no description available]	Cucurbitaceae	The gourd plant family of the order Violales, subclass Dilleniidae, class Magnoliopsida. It is sometimes placed in its own order, Cucurbitales. 'Melon' generally refers to CUCUMIS; CITRULLUS; or MOMORDICA.[MeSH]

Cross-References

ID Source	ID
PubMed CID	10481797
CHEMBL ID	486260
MeSH ID	M000601633

Synonyms (17)

Synonym
50298-90-3
23,24-dihydrocucurbitacin f
dihydrocucurbitacin f
25-deacetyl hemslecin a
CHEMBL486260
AKOS016010575
cucurbitacin iib
AC-34875
cucurbitacin centob
curcurbitacin-iib
mfcd02752610
HY-N1987
CS-0018308
MS-29661
(2s,3s,8s,9r,10r,13r,14s,16r,17r)-17-[(2r)-2,6-dihydroxy-6-methyl-3-oxoheptan-2-yl]-2,3,16-trihydroxy-4,4,9,13,14-pentamethyl-1,2,3,7,8,10,12,15,16,17-decahydrocyclopenta[a]phenanthren-11-one
S0949
DTXSID901314928

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (12)

Assay ID	Title	Year	Journal	Article
AID729826	Selectivity index, ratio of CC50 for human HepG2.2.15 cells to IC50 for HBV infected in human HepG2.2.15 cells assessed as inhibition of viral surface antigen production	2013	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5	Synthesis of hemslecin A derivatives: a new class of hepatitis B virus inhibitors.
AID729825	Antiviral activity against HBV infected in human HepG2.2.15 cells assessed as inhibition of viral e antigen production	2013	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5	Synthesis of hemslecin A derivatives: a new class of hepatitis B virus inhibitors.
AID729823	Antiviral activity against HBV infected in human HepG2.2.15 cells assessed as inhibition of viral DNA replication	2013	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5	Synthesis of hemslecin A derivatives: a new class of hepatitis B virus inhibitors.
AID729822	Selectivity index, ratio of CC50 for human HepG2.2.15 cells to IC50 for HBV infected in human HepG2.2.15 cells assessed as inhibition of viral DNA replication	2013	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5	Synthesis of hemslecin A derivatives: a new class of hepatitis B virus inhibitors.
AID729824	Selectivity index, ratio of CC50 for human HepG2.2.15 cells to IC50 for HBV infected in human HepG2.2.15 cells assessed as inhibition of viral e antigen production	2013	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5	Synthesis of hemslecin A derivatives: a new class of hepatitis B virus inhibitors.
AID399626	Cytotoxicity against mouse P388 cells
AID1140138	Cytotoxicity against human COLO205 cells after 48 hrs by MTT assay	2014	Bioorganic & medicinal chemistry letters, May-01, Volume: 24, Issue:9	Three new cucurbitane triterpenoids from Hemsleya penxianensis and their cytotoxic activities.
AID399625	Cytotoxicity against human KB cells
AID729828	Cytotoxicity against human HepG2.2.15 cells	2013	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5	Synthesis of hemslecin A derivatives: a new class of hepatitis B virus inhibitors.
AID729827	Antiviral activity against HBV infected in human HepG2.2.15 cells assessed as inhibition of viral surface antigen production	2013	Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5	Synthesis of hemslecin A derivatives: a new class of hepatitis B virus inhibitors.
AID1140136	Cytotoxicity against human H460 cells after 48 hrs by MTT assay	2014	Bioorganic & medicinal chemistry letters, May-01, Volume: 24, Issue:9	Three new cucurbitane triterpenoids from Hemsleya penxianensis and their cytotoxic activities.
AID1140137	Cytotoxicity against human SW620 cells after 48 hrs by MTT assay	2014	Bioorganic & medicinal chemistry letters, May-01, Volume: 24, Issue:9	Three new cucurbitane triterpenoids from Hemsleya penxianensis and their cytotoxic activities.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (19)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (10.53)	18.2507
2000's	3 (15.79)	29.6817
2010's	6 (31.58)	24.3611
2020's	8 (42.11)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.98

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.98 (24.57)
Research Supply Index	3.09 (2.92)
Research Growth Index	5.08 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.98)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	21 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
indomethacin Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.. indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.	7.13	1	0	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic
oleanolic acid [no description available]	1.98	1	0	hydroxy monocarboxylic acid; pentacyclic triterpenoid	plant metabolite
cucurbitacins [no description available]	3.93	11	0	11-oxo steroid
cucurbitacin iia cucurbitacin IIa: antineoplastic from the medicinal plant Hemsleya amalils Diels; structure in first source	7.79	3	0
cucurbitacin f cucurbitacin F: structure in first source	2.04	1	0
tenofovir tenofovir (anhydrous) : A member of the class of phosphonic acids that is methylphosphonic acid in which one of the methyl hydrogens is replaced by a [(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy group. An inhibitor of HIV-1 reverse transcriptase, the bis(isopropyloxycarbonyloxymethyl) ester (disoproxil ester) prodrug is used as the fumaric acid salt in combination therapy for the treatment of HIV infection.	2.08	1	0	nucleoside analogue; phosphonic acids	antiviral drug; drug metabolite; HIV-1 reverse transcriptase inhibitor
glycosides [no description available]	2.21	1	0
cytellin cytellin: a phytosterol preparation of mainly B-sitosterol, that was marketed by Eli Lilly to lower cholesterol 1957 to 1982	1.99	1	0
cucurbitacin b [no description available]	2.03	1	0	cucurbitacin; secondary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone
nsc 106399 cucurbitacin E: RN refers to (9beta,10alpha,16alpha,23E)-isomer; structure given in first source. cucurbitacin E : A cucurbitacin in which a lanostane skeleton is multi-substituted with hydroxy, methyl and oxo substituents, with unsaturation at positions 1, 5 and 23.	2.03	1	0	cucurbitacin; tertiary alpha-hydroxy ketone
beta-escin [no description available]	2.39	2	0
chikusetsu saponin iva chikusetsu saponin IVa: from the tubers of Hemsleya pengxianensis (Cucurbitaceae)	1.98	1	0	triterpenoid saponin	metabolite
lyoniside lyoniside: see also eleutherosides & syringin for eleutheroside B: 118-34-3; RN given refers to (3beta)-isomer	1.99	1	0
cucurbitane cucurbitane: structure in first source. cucurbitane : A triterpene that is an isomer of lanostane obtained by migration of the methyl group from 10 to the 9beta position.	2.21	1	0	triterpene
concanavalin a Concanavalin A: A MANNOSE/GLUCOSE binding lectin isolated from the jack bean (Canavalia ensiformis). It is a potent mitogen used to stimulate cell proliferation in lymphocytes, primarily T-lymphocyte, cultures.	2.1	1	0

Condition	Indicated	Relationship Strength	Studies	Trials
Benign Neoplasms [description not available]	0	2.59	2	0
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	0	2.59	2	0
Cancer of Prostate [description not available]	0	2.07	1	0
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	0	2.07	1	0
Cancer of Cervix [description not available]	0	2.41	1	0
Uterine Cervical Neoplasms Tumors or cancer of the UTERINE CERVIX.	0	2.41	1	0
Atrophy, Muscle [description not available]	0	2.6	1	0
Cachexia General ill health, malnutrition, and weight loss, usually associated with chronic disease.	0	7.6	1	0
Muscular Atrophy Derangement in size and number of muscle fibers occurring with aging, reduction in blood supply, or following immobilization, prolonged weightlessness, malnutrition, and particularly in denervation.	0	2.6	1	0
Bladder Cancer [description not available]	0	7.6	1	0
Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER.	0	2.6	1	0
Libman-Sacks Disease [description not available]	0	2.31	1	0
Lupus Erythematosus, Systemic A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.	0	2.31	1	0