cucurbitacin IIa: antineoplastic from the medicinal plant Hemsleya amalils Diels; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Hemsleya | genus | [no description available] | Cucurbitaceae | The gourd plant family of the order Violales, subclass Dilleniidae, class Magnoliopsida. It is sometimes placed in its own order, Cucurbitales. 'Melon' generally refers to CUCUMIS; CITRULLUS; or MOMORDICA.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 181183 |
| CHEMBL ID | 2332392 |
| MeSH ID | M0556890 |
| Synonym |
|---|
| cucurbitacin iia |
| [(6r)-6-hydroxy-2-methyl-5-oxo-6-[(2s,3s,8s,9r,10r,13r,14s,16r,17r)-2,3,16-trihydroxy-4,4,9,13,14-pentamethyl-11-oxo-1,2,3,7,8,10,12,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]heptan-2-yl] acetate |
| 25-o-acetyl-23,24-dihydrocucurbitacin f |
| dihydrocucurbitacin f 25-o-acetate |
| 23,24-dihydrocucurbitacin f-25-o-acetate |
| 19-norlanost-5-ene-11,22-dione, 25-(acetyloxy)-2,3,16,20-tetrahydroxy-9-methyl-, (2beta,3alpha,9beta,10alpha,16alpha)- |
| 58546-34-2 |
| dihydrocucurbitacin q1 |
| S5463 |
| hemslecin a |
| CHEMBL2332392 |
| Q-100672 |
| [(5r)-5-hydroxy-1,1-dimethyl-4-oxo-5-[(2s,3s,8s,9r,10r,13r,14s,16r,17r)-2,3,16-trihydroxy-4,4,9,13,14-pentamethyl-11-oxo-1,2,3,7,8,10,12,15,16,17-decahydrocyclopenta[a]phenanthren-17-yl]hexyl] acetate |
| curcurbitacin iia |
| AKOS030573647 |
| DTXSID10926388 |
| 1,2,16,20-tetrahydroxy-9,10,14-trimethyl-11,22-dioxo-4,9-cyclo-9,10-secocholest-5-en-25-yl acetate |
| 129357-90-0 |
| mfcd07781419 |
| HY-N1988 |
| CS-0018309 |
| CCG-270062 |
| hemslecin a ;cucurbitacin iia |
| MS-30213 |
| 19-norlanost-5-ene-11,22-dione,25-(acetyloxy)-2,3,16,20-tetrahydroxy-9-methyl-, (2b,3a,9b,10a,16a)- |
| AC-34888 |
| hemslecina |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID729822 | Selectivity index, ratio of CC50 for human HepG2.2.15 cells to IC50 for HBV infected in human HepG2.2.15 cells assessed as inhibition of viral DNA replication | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis of hemslecin A derivatives: a new class of hepatitis B virus inhibitors. |
| AID729827 | Antiviral activity against HBV infected in human HepG2.2.15 cells assessed as inhibition of viral surface antigen production | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis of hemslecin A derivatives: a new class of hepatitis B virus inhibitors. |
| AID729825 | Antiviral activity against HBV infected in human HepG2.2.15 cells assessed as inhibition of viral e antigen production | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis of hemslecin A derivatives: a new class of hepatitis B virus inhibitors. |
| AID1140136 | Cytotoxicity against human H460 cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, May-01, Volume: 24, Issue:9 | Three new cucurbitane triterpenoids from Hemsleya penxianensis and their cytotoxic activities. |
| AID729828 | Cytotoxicity against human HepG2.2.15 cells | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis of hemslecin A derivatives: a new class of hepatitis B virus inhibitors. |
| AID729824 | Selectivity index, ratio of CC50 for human HepG2.2.15 cells to IC50 for HBV infected in human HepG2.2.15 cells assessed as inhibition of viral e antigen production | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis of hemslecin A derivatives: a new class of hepatitis B virus inhibitors. |
| AID1140138 | Cytotoxicity against human COLO205 cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, May-01, Volume: 24, Issue:9 | Three new cucurbitane triterpenoids from Hemsleya penxianensis and their cytotoxic activities. |
| AID729823 | Antiviral activity against HBV infected in human HepG2.2.15 cells assessed as inhibition of viral DNA replication | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis of hemslecin A derivatives: a new class of hepatitis B virus inhibitors. |
| AID729826 | Selectivity index, ratio of CC50 for human HepG2.2.15 cells to IC50 for HBV infected in human HepG2.2.15 cells assessed as inhibition of viral surface antigen production | 2013 | Bioorganic & medicinal chemistry letters, Mar-01, Volume: 23, Issue:5 | Synthesis of hemslecin A derivatives: a new class of hepatitis B virus inhibitors. |
| AID1140137 | Cytotoxicity against human SW620 cells after 48 hrs by MTT assay | 2014 | Bioorganic & medicinal chemistry letters, May-01, Volume: 24, Issue:9 | Three new cucurbitane triterpenoids from Hemsleya penxianensis and their cytotoxic activities. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 8 (72.73) | 24.3611 |
| 2020's | 3 (27.27) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.10) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (9.09%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 10 (90.91%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||