Compounds > combretastatin a3

Page last updated: 2024-12-11

combretastatin a3

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

combretastatin A3: RN given for (Z)-isomer; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	6444140
CHEMBL ID	464382
SCHEMBL ID	13813246
MeSH ID	M0407327

Synonyms (15)

Synonym
combretastatin a3
combretastatin a-3
combretastatins a-3
CHEMBL464382
5-[(z)-2-(3-hydroxy-4-methoxyphenyl)ethenyl]-2,3-dimethoxyphenol
111394-45-7
n64zkx59ne ,
unii-n64zkx59ne
SCHEMBL13813246
(z)-5-(3-hydroxy-4-methoxystyryl)-2,3-dimethoxyphenol
phenol, 5-((1z)-2-(3-hydroxy-4-methoxyphenyl)ethenyl)-2,3-dimethoxy-
5-((1z)-2-(3-hydroxy-4-methoxyphenyl)ethenyl)-2,3-dimethoxyphenol
combretastatin 3
phenol, 5-(2-(3-hydroxy-4-methoxyphenyl)ethenyl)-2,3-dimethoxy-, (z)-
combrestatin a4 metabolite m6

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (15)

Assay ID	Title	Year	Journal	Article
AID657879	Growth inhibition of human SF268 cells after 48 hrs by sulforhodamine B assay	2012	Journal of natural products, Mar-23, Volume: 75, Issue:3	Antineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs.
AID403643	Cytotoxicity against human MCF7 cells after 48 hrs by sulforhodamine B assay	2005	Journal of natural products, Oct, Volume: 68, Issue:10	Antineoplastic agents. 509: synthesis of fluorcombstatin phosphate and related 3-halostilbenes(1).
AID657878	Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay	2012	Journal of natural products, Mar-23, Volume: 75, Issue:3	Antineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs.
AID403641	Cytotoxicity against mouse P388 cells after 48 hrs by sulforhodamine B assay	2005	Journal of natural products, Oct, Volume: 68, Issue:10	Antineoplastic agents. 509: synthesis of fluorcombstatin phosphate and related 3-halostilbenes(1).
AID657876	Growth inhibition of mouse P388 cells after 48 hrs by Z1 Beckman/Coulter particle counter analysis	2012	Journal of natural products, Mar-23, Volume: 75, Issue:3	Antineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs.
AID403646	Cytotoxicity against human KM20L2 cells after 48 hrs by sulforhodamine B assay	2005	Journal of natural products, Oct, Volume: 68, Issue:10	Antineoplastic agents. 509: synthesis of fluorcombstatin phosphate and related 3-halostilbenes(1).
AID657881	Growth inhibition of human KM20L2 cells after 48 hrs by sulforhodamine B assay	2012	Journal of natural products, Mar-23, Volume: 75, Issue:3	Antineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs.
AID403647	Cytotoxicity against human DU145 cells after 48 hrs by sulforhodamine B assay	2005	Journal of natural products, Oct, Volume: 68, Issue:10	Antineoplastic agents. 509: synthesis of fluorcombstatin phosphate and related 3-halostilbenes(1).
AID403644	Cytotoxicity against human SF268 cells after 48 hrs by sulforhodamine B assay	2005	Journal of natural products, Oct, Volume: 68, Issue:10	Antineoplastic agents. 509: synthesis of fluorcombstatin phosphate and related 3-halostilbenes(1).
AID657882	Growth inhibition of human DU145 cells after 48 hrs by sulforhodamine B assay	2012	Journal of natural products, Mar-23, Volume: 75, Issue:3	Antineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs.
AID657880	Growth inhibition of human NCI-H460 cells after 48 hrs by sulforhodamine B assay	2012	Journal of natural products, Mar-23, Volume: 75, Issue:3	Antineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs.
AID657877	Growth inhibition of human BxPC3 cells after 48 hrs by sulforhodamine B assay	2012	Journal of natural products, Mar-23, Volume: 75, Issue:3	Antineoplastic agents. 548. Synthesis of iodo- and diiodocombstatin phosphate prodrugs.
AID403645	Cytotoxicity against human NCI-H460 cells after 48 hrs by sulforhodamine B assay	2005	Journal of natural products, Oct, Volume: 68, Issue:10	Antineoplastic agents. 509: synthesis of fluorcombstatin phosphate and related 3-halostilbenes(1).
AID397288	Cytotoxicity against mouse P388 cells	2009	Journal of medicinal chemistry, Jul-23, Volume: 52, Issue:14	Isocombretastatins a versus combretastatins a: the forgotten isoCA-4 isomer as a highly promising cytotoxic and antitubulin agent.
AID403642	Cytotoxicity against human BxPC3 cells after 48 hrs by sulforhodamine B assay	2005	Journal of natural products, Oct, Volume: 68, Issue:10	Antineoplastic agents. 509: synthesis of fluorcombstatin phosphate and related 3-halostilbenes(1).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	4 (80.00)	29.6817
2010's	1 (20.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.87 (24.57)
Research Supply Index	1.79 (2.92)
Research Growth Index	4.66 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.87)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (20.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	4 (80.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
colchicine (S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.	2.05	1	0	alkaloid; colchicine	anti-inflammatory agent; gout suppressant; mutagen
stilbenes Stilbenes: Organic compounds that contain 1,2-diphenylethylene as a functional group.. trans-stilbene : The trans-isomer of stilbene.	3.51	2	0	stilbene
fosbretabulin [no description available]	2.74	3	0	stilbenoid
nsc 600032 combretastatin A-1: from Combretum caffrum; structure given in first source	2.44	2	0
combretastatin a-4 disodium phosphate [no description available]	2.45	2	0
combretastatin a-2 combretastatin A-2: isolated from Combretum caffrum; RN from first source; structure given in first source	2.05	1	0
isocombretastatin a-4 [no description available]	2.05	1	0

Condition	Indicated	Relationship Strength	Studies	Trials
Leukemia P388 An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.	0	2.02	1	0
Benign Neoplasms [description not available]	0	2.94	1	0
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	0	2.94	1	0