Page last updated: 2024-12-11
codorphone
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Description
codorphone: analgesic activity in range of morphine & pentazocine but with no physical dependence caused in rats; RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 5361887 |
| CHEMBL ID | 2110790 |
| SCHEMBL ID | 488917 |
| MeSH ID | M0084901 |
Synonyms (21)
| Synonym |
|---|
| codorphone |
| morphinan-6-one, 17-cyclopropylmethyl-4,5-epoxy-8-ethyl-3-methoxy-, (5alpha,8beta)- |
| conorfone |
| conorphone |
| 9h58696d23 , |
| conorfonum [inn-latin] |
| unii-9h58696d23 |
| (5r,8r,9r,13s,14r)-n-cyclopropylmethyl-4,5-epoxy-8-ethyl-3-methoxy-6-morphinanon |
| conorfonum |
| 72060-05-0 |
| conorfone [inn] |
| conorfona |
| 17-(cyclopropylmethyl)-4,5alpha-epoxy-8beta-ethyl-3-methoxymorphinan-6-one |
| conorfona [inn-spanish] |
| 17-(cyclopropylmethyl)-4,5.alpha.-epoxy-8.beta.-ethyl-3-methoxymorphinan-6-one |
| morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-8-ethyl-3-methoxy-, (5.alpha.,8.beta.)- |
| SCHEMBL488917 |
| CHEMBL2110790 |
| conorfone; conorphone; tr 5109 |
| DTXSID501016499 |
| (4r,4ar,5s,7ar,12bs)-3-(cyclopropylmethyl)-5-ethyl-9-methoxy-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one |
Research Excerpts
Bioavailability
| Excerpt | Reference | Relevance |
|---|---|---|
| " The compound appeared to be well absorbed in the three species." | ( Disposition and metabolism of codorphone in the rat, dog, and man. Evans, JV; Helms, RJ; Leeling, JL; Ryerson, BA, ) | 0.42 |
Dosage Studied
| Excerpt | Relevance | Reference |
|---|---|---|
| " To illustrate the usefulness of this methodology, a urine sample obtained from a dog that had been dosed with codorphone was analyzed by gas chromatography mass spectrometry, and the metabolites were identified by comparison to the mass spectra of the synthetic derivatives." | ( Methodology for the identification of the urinary metabolites of the analgesic-narcotic antagonist, codorphone, by gas chromatography mass spectrometry. Evans, JV; Helms, RJ; Leeling, JL, 1982) | 0.69 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Research
Studies (3)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (66.67) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 6 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||