Page last updated: 2024-12-11

codorphone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

codorphone: analgesic activity in range of morphine & pentazocine but with no physical dependence caused in rats; RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5361887
CHEMBL ID2110790
SCHEMBL ID488917
MeSH IDM0084901

Synonyms (21)

Synonym
codorphone
morphinan-6-one, 17-cyclopropylmethyl-4,5-epoxy-8-ethyl-3-methoxy-, (5alpha,8beta)-
conorfone
conorphone
9h58696d23 ,
conorfonum [inn-latin]
unii-9h58696d23
(5r,8r,9r,13s,14r)-n-cyclopropylmethyl-4,5-epoxy-8-ethyl-3-methoxy-6-morphinanon
conorfonum
72060-05-0
conorfone [inn]
conorfona
17-(cyclopropylmethyl)-4,5alpha-epoxy-8beta-ethyl-3-methoxymorphinan-6-one
conorfona [inn-spanish]
17-(cyclopropylmethyl)-4,5.alpha.-epoxy-8.beta.-ethyl-3-methoxymorphinan-6-one
morphinan-6-one, 17-(cyclopropylmethyl)-4,5-epoxy-8-ethyl-3-methoxy-, (5.alpha.,8.beta.)-
SCHEMBL488917
CHEMBL2110790
conorfone; conorphone; tr 5109
DTXSID501016499
(4r,4ar,5s,7ar,12bs)-3-(cyclopropylmethyl)-5-ethyl-9-methoxy-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" The compound appeared to be well absorbed in the three species."( Disposition and metabolism of codorphone in the rat, dog, and man.
Evans, JV; Helms, RJ; Leeling, JL; Ryerson, BA,
)
0.42

Dosage Studied

ExcerptRelevanceReference
" To illustrate the usefulness of this methodology, a urine sample obtained from a dog that had been dosed with codorphone was analyzed by gas chromatography mass spectrometry, and the metabolites were identified by comparison to the mass spectra of the synthetic derivatives."( Methodology for the identification of the urinary metabolites of the analgesic-narcotic antagonist, codorphone, by gas chromatography mass spectrometry.
Evans, JV; Helms, RJ; Leeling, JL, 1982
)
0.69
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (3)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (66.67)18.7374
1990's1 (33.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]