Compounds > clazuril
Page last updated: 2024-11-06

clazuril

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Clazuril is a synthetic antiprotozoal drug that is primarily used to treat coccidiosis in poultry. It is an imidazo[1,2-a]pyridine derivative with a unique mechanism of action. Clazuril inhibits the development of the parasite Eimeria spp., which causes coccidiosis. It does this by disrupting the parasite's mitochondrial function, leading to its death. Clazuril is highly effective in controlling coccidiosis and is considered a safe and effective treatment option for poultry. However, there is some concern about the potential for drug resistance to develop. Research on clazuril focuses on understanding its mechanism of action, optimizing its efficacy, and investigating its potential application for other diseases. Clazuril is studied to understand its efficacy in treating other parasitic diseases and to investigate its potential for use in human medicine.'

Cross-References

ID SourceID
PubMed CID58901
CHEMBL ID2104190
SCHEMBL ID466311
MeSH IDM0157664

Synonyms (36)

Synonym
clazuril (usan/inn)
101831-36-1
D03533
clazuril
r 62690
2-[2-chloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenyl]-2-(4-chlorophenyl)acetonitrile
[2-chloro-4-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3h)-yl)phenyl](4-chlorophenyl)acetonitrile
r62,690
o8w0r05772 ,
clazurilo
(2-chloro-4-(4,5-dihydro-3,5-dioxo-as-triazin-2(3h)-yl)phenyl)(p-chlorophenyl)acetonitrile
clazuril [usan:inn:ban]
clazurilum [latin]
clazurilum
unii-o8w0r05772
clazurilo [spanish]
CHEMBL2104190
r-62690
(+/-)-clazuril
clazuril [inn]
clazuril [mi]
clazuril [usan]
clazuril, (+/-)-
clazuril [mart.]
benzeneacetonitrile, 2-chloro-.alpha.-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3h)-yl)-
2-chloro-alpha-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2-(3h)-yl)benzeneacetonitrile
QUUTUGLQZLNABV-UHFFFAOYSA-N
2-chloro-alpha-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3h)-yl)benzeneacetonitrile
SCHEMBL466311
Q3680360
DTXSID30869364
2-(2-chloro-4-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3h)-yl)phenyl)-2-(4-chlorophenyl)acetonitrile
HY-101000
clazuril for system suitability
CS-0018222
AKOS040746710

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" This study was set up to develop a new high pressure liquid chromatography (HPLC) method to detect clazuril (CZ: (+/-)-2-chloro-alpha-(4-chlorophenyl)-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-benzeneacetonitrile) in egg yolk and albumen and in plasma; to investigate both the presence of residues of CZ in eggs and its pharmacokinetic behaviour in laying hens."( Pharmacokinetic study of clazuril (Appertex) in eggs and plasma from laying hens after single or multiple treatments, using a new HPLC method for detection.
Giorgi, M; Soldani, G, 2008)		0.87

Dosage Studied

ExcerptRelevanceReference
" After treatment with toltrazuril, there was a dose-dependent period during which pigeons remained negative; at a dosage of 35 mg/kg or higher, this period was at least 4 weeks."( Efficacy of toltrazuril and clazuril against experimental infections with Eimeria labbeana and E. columbarum in racing pigeons.
Vercruysse, J, )		0.43
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (50.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 29.15

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index29.15 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.16 (4.65)
Search Engine Demand Index34.37 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (29.15)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (14.29%)5.53%
Reviews1 (14.29%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (71.43%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
amprolium
Amprolium: A veterinary coccidiostat that interferes with THIAMINE metabolism.. amprolium : An organic chloride salt having 1-[(4-amino-2-propylpyrimidin-5-yl)methyl]-2-methylpyridin-1-ium as the counterion. Used for prevention of coccidiosis in poultry and cattle.. amprolium(1+) : A pyridinium ion that is the cationic portion of amprolium, a veterinary drug which is used for prevention of coccidiosis in poultry and cattle.		2.0210pyridinium ioncoccidiostat
toltrazuril
toltrazuril: structure in first source		3.2710aromatic ether
monensin
Monensin: An antiprotozoal agent produced by Streptomyces cinnamonensis. It exerts its effect during the development of first-generation trophozoites into first-generation schizonts within the intestinal epithelial cells. It does not interfere with hosts' development of acquired immunity to the majority of coccidial species. Monensin is a sodium and proton selective ionophore and is widely used as such in biochemical studies.. monensin A : A spiroketal, monensin A is the major component of monensin, a mixture of antibiotic substances produced by Streptomyces cinnamonensis. An antiprotozoal, it is used as the sodium salt as a feed additive for the prevention of coccidiosis in poultry and as a growth promoter in cattle.		2.0210cyclic hemiketal;
monocarboxylic acid;
polyether antibiotic;
spiroketal		antifungal agent;
coccidiostat;
ionophore
diclazuril
[no description available]		3.2710nitrile
ponazuril
ponazuril: a major metabolite of toltrazuril		3.2710
2-(3-methyl-4-(4-nitrophenoxy)phenyl)-1,2,4-triazine-3,5(2h,4h)-dione
2-(3-methyl-4-(4-nitrophenoxy)phenyl)-1,2,4-triazine-3,5(2H,4H)-dione: a coccidiostat		3.2710
ConditionIndicatedRelationship StrengthStudiesTrials
Protozoan Infections, Animal
Infections with unicellular organisms formerly members of the subkingdom Protozoa. The infections may be experimental or veterinary.		03.0910
Besnoitiasis
[description not available]		03.8340
Encephalitis, Equine
[description not available]		03.0910
Toxoplasmosis, Animal
Acquired infection of non-human animals by organisms of the genus TOXOPLASMA.		03.0910
Avian Diseases
[description not available]		02.6730
Intestinal Diseases, Parasitic
Infections of the INTESTINES with PARASITES, commonly involving PARASITIC WORMS. Infections with roundworms (NEMATODE INFECTIONS) and tapeworms (CESTODE INFECTIONS) are also known as HELMINTHIASIS.		01.9710
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		01.9710