Page last updated: 2024-11-13

claulansine f

Description

claulansine F: a free radical scavenger isolated from the stem of Clausena lansium; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
ClausenagenusA plant genus of the family RUTACEAE. Members contain anethole and CARBAZOLES.[MeSH]RutaceaeA plant family in the order Sapindales that grows in warmer regions and has conspicuous flowers.[MeSH]

Cross-References

ID SourceID
PubMed CID57409550
CHEMBL ID2035835
MeSH IDM000594559

Synonyms (2)

Synonym
claulansine f
CHEMBL2035835
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID1671813Anticancer activity against human DU-145 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay2019European journal of medicinal chemistry, Apr-01, Volume: 167Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells.
AID664751Neuroprotective activity in rat PC12 cells assessed as inhibition of serum starvation-induced cell death after 24 hrs by MTT assay2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Carbazole alkaloids from the stems of Clausena lansium.
AID1671811Anticancer activity against human MCF7 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay2019European journal of medicinal chemistry, Apr-01, Volume: 167Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells.
AID1671812Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay2019European journal of medicinal chemistry, Apr-01, Volume: 167Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells.
AID1671818Cytotoxicity against HEK293 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay2019European journal of medicinal chemistry, Apr-01, Volume: 167Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells.
AID664750Neuroprotective activity in rat PC12 cells assessed as inhibition of SNP-induced cell death at 10 uM incubated 24 hrs post SNP-challenge for 24 hrs by MTT assay2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Carbazole alkaloids from the stems of Clausena lansium.
AID1348564Cytoprotective activity against H2O2-induced damage in rat PC12 cells assessed as cell viability at 10 uM after 24 hrs by MTT assay (Rvb = 70.1 +/- 3.7%)2018European journal of medicinal chemistry, Jan-01, Volume: 143Pyrano[3,2-a]carbazole alkaloids as effective agents against ischemic stroke in vitro and in vivo.
AID1671815Anticancer activity against human HepG2 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay2019European journal of medicinal chemistry, Apr-01, Volume: 167Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells.
AID1348566Cytoprotective activity against oxygen-glucose deprivation/reoxygenation-induced damage in rat PC12 cells assessed as cell viability at 10 uM after 24 hrs by MTT assay (Rvb = 70 +/- 5.1%)2018European journal of medicinal chemistry, Jan-01, Volume: 143Pyrano[3,2-a]carbazole alkaloids as effective agents against ischemic stroke in vitro and in vivo.
AID664749Neuroprotective activity in rat PC12 cells assessed as inhibition of amyloid beta(25 to 35)-induced cell death at 10 uM incubated 48 hrs post amyloid beta-challenge for 24 hrs by MTT assay2012Journal of natural products, Apr-27, Volume: 75, Issue:4
Carbazole alkaloids from the stems of Clausena lansium.
AID1671814Anticancer activity against human PC-3 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay2019European journal of medicinal chemistry, Apr-01, Volume: 167Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells.
AID1671816Anticancer activity against human DLD-1 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay2019European journal of medicinal chemistry, Apr-01, Volume: 167Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells.
AID1671817Anticancer activity against human A549 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay2019European journal of medicinal chemistry, Apr-01, Volume: 167Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's6 (85.71)24.3611
2020's1 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.43

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.43 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.43)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other7 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
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