claulansine f

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

claulansine F: a free radical scavenger isolated from the stem of Clausena lansium; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Clausena	genus	A plant genus of the family RUTACEAE. Members contain anethole and CARBAZOLES.[MeSH]	Rutaceae	A plant family in the order Sapindales that grows in warmer regions and has conspicuous flowers.[MeSH]

Cross-References

ID Source	ID
PubMed CID	57409550
CHEMBL ID	2035835
MeSH ID	M000594559

Synonyms (2)

Synonym
claulansine f
CHEMBL2035835

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay ID	Title	Year	Journal	Article
AID1671813	Anticancer activity against human DU-145 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay	2019	European journal of medicinal chemistry, Apr-01, Volume: 167	Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells.
AID664751	Neuroprotective activity in rat PC12 cells assessed as inhibition of serum starvation-induced cell death after 24 hrs by MTT assay	2012	Journal of natural products, Apr-27, Volume: 75, Issue:4	Carbazole alkaloids from the stems of Clausena lansium.
AID1671811	Anticancer activity against human MCF7 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay	2019	European journal of medicinal chemistry, Apr-01, Volume: 167	Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells.
AID1671812	Anticancer activity against human MDA-MB-231 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay	2019	European journal of medicinal chemistry, Apr-01, Volume: 167	Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells.
AID1671818	Cytotoxicity against HEK293 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay	2019	European journal of medicinal chemistry, Apr-01, Volume: 167	Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells.
AID664750	Neuroprotective activity in rat PC12 cells assessed as inhibition of SNP-induced cell death at 10 uM incubated 24 hrs post SNP-challenge for 24 hrs by MTT assay	2012	Journal of natural products, Apr-27, Volume: 75, Issue:4	Carbazole alkaloids from the stems of Clausena lansium.
AID1348564	Cytoprotective activity against H2O2-induced damage in rat PC12 cells assessed as cell viability at 10 uM after 24 hrs by MTT assay (Rvb = 70.1 +/- 3.7%)	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	Pyrano[3,2-a]carbazole alkaloids as effective agents against ischemic stroke in vitro and in vivo.
AID1671815	Anticancer activity against human HepG2 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay	2019	European journal of medicinal chemistry, Apr-01, Volume: 167	Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells.
AID1348566	Cytoprotective activity against oxygen-glucose deprivation/reoxygenation-induced damage in rat PC12 cells assessed as cell viability at 10 uM after 24 hrs by MTT assay (Rvb = 70 +/- 5.1%)	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	Pyrano[3,2-a]carbazole alkaloids as effective agents against ischemic stroke in vitro and in vivo.
AID664749	Neuroprotective activity in rat PC12 cells assessed as inhibition of amyloid beta(25 to 35)-induced cell death at 10 uM incubated 48 hrs post amyloid beta-challenge for 24 hrs by MTT assay	2012	Journal of natural products, Apr-27, Volume: 75, Issue:4	Carbazole alkaloids from the stems of Clausena lansium.
AID1671814	Anticancer activity against human PC-3 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay	2019	European journal of medicinal chemistry, Apr-01, Volume: 167	Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells.
AID1671816	Anticancer activity against human DLD-1 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay	2019	European journal of medicinal chemistry, Apr-01, Volume: 167	Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells.
AID1671817	Anticancer activity against human A549 cells assessed as cell growth inhibition measured after 24 hrs by MTT assay	2019	European journal of medicinal chemistry, Apr-01, Volume: 167	Pyranocarbazole derivatives as potent anti-cancer agents triggering tubulin polymerization stabilization induced activation of caspase-dependent apoptosis and downregulation of Akt/mTOR in breast cancer cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	6 (85.71)	24.3611
2020's	1 (14.29)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.43

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.43 (24.57)
Research Supply Index	2.08 (2.92)
Research Growth Index	4.51 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.43)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
carbonyl cyanide m-chlorophenyl hydrazone Carbonyl Cyanide m-Chlorophenyl Hydrazone: A proton ionophore. It is commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes.. CCCP : A member of the class of monochlorobenzenes that is benzene substituted by 2-(1,3-dinitrilopropan-2-ylidene)hydrazinyl and chloro groups at positions 1 and 3, respectively. It is a mitochondrial depolarizing agent that induces reactive oxygen species mediated cell death.	2.21	1	hydrazone; monochlorobenzenes; nitrile	antibacterial agent; geroprotector; ionophore
edaravone [no description available]	2.17	1	pyrazolone	antioxidant; radical scavenger
cuprizone [no description available]	7.25	1	organonitrogen compound; organooxygen compound
paclitaxel Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).	2.21	1	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent
3-n-butylphthalide 3-n-butylphthalide: isolated from phenolic part of Ligusticum wallichii Franch; structure given in first source	2.17	1	benzofurans
murrayanine murrayanine: carbazole alkaloid from Murraya koenigii; structure in first source	2.07	1	carbazoles	metabolite
tamoxifen citrate [no description available]	2.21	1	citrate salt	angiogenesis inhibitor; anticoronaviral agent

Condition	Relationship Strength	Studies
Apoplexy [description not available]	2.17	1
Cerebral Ischemia [description not available]	2.17	1
Brain Ischemia Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.	2.17	1
Stroke A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)	2.17	1
Breast Cancer [description not available]	2.21	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.21	1
Clinically Isolated CNS Demyelinating Syndrome [description not available]	2.25	1
Demyelinating Diseases Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.	2.25	1

chemdatabank.com