Compounds > cj-15,801
Page last updated: 2024-12-11

cj-15,801

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

CJ-15,801: an antibiotic from a fungus, Seimatosporium sp; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6917384
CHEMBL ID4164243
CHEBI ID189351
SCHEMBL ID14862614
MeSH IDM0417080

Synonyms (9)

Synonym
CMLDBU00003444
CHEBI:189351
(e)-3-[[(2r)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]prop-2-enoic acid
cj-15,801
bdbm50285609
chembl4164243 ,
CJ-15801 ,
SCHEMBL14862614
gtpl10610
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
olefinic compoundAny organic molecular entity that contains at least one C=C bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID1349245Cytotoxicity against human WI38 cells assessed as inhibition of cell proliferation at 100 uM after 48 hrs by CellTiter-Glo assay relative to control2018European journal of medicinal chemistry, Jan-01, Volume: 143Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation.
AID1349236Inhibition of pantothenate kinase in Plasmodium falciparum 3D7 trophozoites at 100 uM using [14C]pantothenate as substrate after 15 to 60 mins by TopCount scintillation counting method relative to control2018European journal of medicinal chemistry, Jan-01, Volume: 143Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation.
AID1349246Selectivity index, ratio of cytotoxic concentration for HEK293 cells to IC50 for Plasmodium falciparum 3D7 infected in human erythrocytes in presence of 1 uM pantothenate2018European journal of medicinal chemistry, Jan-01, Volume: 143Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation.
AID1349240Glutathione reactivity at pH 7.4 after 2 hrs by 1H NMR analysis2018European journal of medicinal chemistry, Jan-01, Volume: 143Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation.
AID1349235Ratio of IC50 for Plasmodium falciparum 3D7 infected in human erythrocytes in presence of 100 uM pantothenate to IC50 for Plasmodium falciparum 3D7 infected in human erythrocytes in presence of 1 uM pantothenate2018European journal of medicinal chemistry, Jan-01, Volume: 143Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation.
AID1576481Antimalarial activity against Plasmodium falciparum infected in erythrocytes in presence of 100 uM pantothenic acid and TBA salt form by SYBR safe-based fluorescence assay2019MedChemComm, Dec-01, Volume: 10, Issue:12
Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801.
AID1349244Cytotoxicity against HEK293 cells assessed as inhibition of cell proliferation at 100 uM after 96 hrs by CellTiter-Glo assay relative to control2018European journal of medicinal chemistry, Jan-01, Volume: 143Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation.
AID1576479Antimalarial activity against Plasmodium falciparum infected in erythrocytes in presence of 1 uM pantothenic acid by SYBR safe-based fluorescence assay2019MedChemComm, Dec-01, Volume: 10, Issue:12
Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801.
AID1576480Antimalarial activity against Plasmodium falciparum infected in erythrocytes in presence of 1 uM pantothenic acid and TBA salt form by SYBR safe-based fluorescence assay2019MedChemComm, Dec-01, Volume: 10, Issue:12
Overcoming synthetic challenges in targeting coenzyme A biosynthesis with the antimicrobial natural product CJ-15,801.
AID1349233Antimalarial activity against blood stage of Plasmodium falciparum in presence of pantothenate by [3H]hypoxanthine incorporation assay2018European journal of medicinal chemistry, Jan-01, Volume: 143Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation.
AID1349234Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 96 hrs in presence of 1 uM pantothenate by SYBR green fluorescence-based method2018European journal of medicinal chemistry, Jan-01, Volume: 143Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation.
AID1349241Cysteine reactivity at pH 7.4 after 2 hrs by 1H NMR analysis2018European journal of medicinal chemistry, Jan-01, Volume: 143Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation.
AID1349237Inhibition of pantothenate kinase in Plasmodium falciparum 3D7 trophozoites using [14C]pantothenate as substrate after 15 mins by TopCount scintillation counting method2018European journal of medicinal chemistry, Jan-01, Volume: 143Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation.
AID1349247Selectivity index, ratio of cytotoxic concentration for human WI38 cells to IC50 for Plasmodium falciparum 3D7 infected in human erythrocytes in presence of 1 uM pantothenate2018European journal of medicinal chemistry, Jan-01, Volume: 143Structure-activity analysis of CJ-15,801 analogues that interact with Plasmodium falciparum pantothenate kinase and inhibit parasite proliferation.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (37.50)29.6817
2010's5 (62.50)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.47

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.47 (24.57)
Research Supply Index2.20 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.47)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
carbamates
[no description available]		2.0210amino-acid anion
urea
pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.		2.0210isourea;
monocarboxylic acid amide;
one-carbon compound		Daphnia magna metabolite;
Escherichia coli metabolite;
fertilizer;
flour treatment agent;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
ethylmaleimide
Ethylmaleimide: A sulfhydryl reagent that is widely used in experimental biochemical studies.		2.1710maleimidesanticoronaviral agent;
EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor;
EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor;
EC 2.7.1.1 (hexokinase) inhibitor
pantothenic acid
Pantothenic Acid: A butyryl-beta-alanine that can also be viewed as pantoic acid complexed with BETA ALANINE. It is incorporated into COENZYME A and protects cells against peroxidative damage by increasing the level of GLUTATHIONE.. pantothenic acid : A member of the class of pantothenic acids that is an amide formed from pantoic acid and beta-alanine.. vitamin B5 : Any member of a group of vitamers that belong to the chemical structural class called pantothenic acids that exhibit biological activity against vitamin B5 deficiency. Deficiency of vitamin B5 is rare due to its widespread distribution in whole grain cereals, legumes and meat. Symptoms associated with vitamin B5 deficiency are difficult to asses since they are subtle and resemble those of other B vitamin deficiencies. The vitamers include (R)-pantothenic acid and its ionized and salt forms.. (R)-pantothenate : A pantothenate that is the conjugate base of (R)-pantothenic acid, obtained by deprotonation of the carboxy group.. (R)-pantothenic acid : A pantothenic acid having R-configuration.		3.4470pantothenic acid;
vitamin B5		antidote to curare poisoning;
geroprotector;
human blood serum metabolite
tetrabutylammonium
tetrabutylammonium: lipophilic probe; RN given refers to parent cpd		2.2110quaternary ammonium ion
coenzyme a
[no description available]		2.5220adenosine 3',5'-bisphosphatecoenzyme;
Escherichia coli metabolite;
mouse metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Infections, Plasmodium
[description not available]		02.1710
Malaria
A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.		02.1710
Infections, Staphylococcal
[description not available]		02.0710
Staphylococcal Infections
Infections with bacteria of the genus STAPHYLOCOCCUS.		02.0710