Page last updated: 2024-12-06

citrus red no. 2

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Citrus Red No. 2 is a synthetic dye that is used to color the skin of oranges and grapefruits. It is a mixture of two compounds: 1-(2,5-dimethylphenylazo)-2-naphthol (Sudan Red 7B) and 1-(4-diethylamino-2-methylphenylazo)-2-naphthol. The dye is applied to the fruit about 2-3 weeks before harvest. The dye is absorbed into the fruit and gives it a more uniform color. It is also believed to help prevent the fruit from becoming overripe. Citrus Red No. 2 has been studied extensively for its safety. The FDA has determined that it is safe for use on oranges and grapefruits at the recommended levels. However, some studies have shown that the dye may be carcinogenic in animals. More research is needed to determine if Citrus Red No. 2 is carcinogenic in humans. The dye is used because it helps to make the fruit more attractive to consumers and also helps to extend the shelf life of the fruit.'

Cross-References

ID SourceID
PubMed CID22830
CHEMBL ID3560990
CHEBI ID82306
SCHEMBL ID9108481
SCHEMBL ID1486044
MeSH IDM0050037

Synonyms (62)

Synonym
ccris 1875
ci 12156
1-((2,5-dimethoxyphenyl)azo)-2-naphthol
1-((2,5-dimethoxyphenyl)azo)-2-naphthalenol
1-(1-(2,5-dimethoxyphenyl)azo)-2-naphthol
brn 4510811
cerven rozpoustedlova 80 [czech]
2-naphthol, 1-((2,5-dimethoxyphenyl)azo)-
1-(2,5-dimethoxyphenylazo)-2-naphthol
1-(2,5-dimethyloxyphenylazo)-2-naphthol
hsdb 2948
2,5-dimethoxybenzeneazo-beta-naphthol
solvent red 80
ci solvent red 80
einecs 228-778-9
2-naphthol, 1-(2,5-dimethoxyphenylazo)-
citrus red
2-naphthalenol, 1-((2,5-dimethoxyphenyl)azo)-
2,5-dimethoxy-1-(phenylazo)-2-naphthol
c.i. solvent red 80
citrus red no. 2
citrus red 2
2,5-dimethoxy-1-phenylazo-2-naphthol
c.i. solvent red 80 (8ci)
6358-53-8
1-[(e)-(2,5-dimethoxyphenyl)diazenyl]-2-naphthol
c.i. 12156
SCHEMBL9108481
AKOS003581987
citrus red no.2
C19214
1-((2,5-dimethoxyphenyl)diazenyl)naphthalen-2-ol
2qe5y68984 ,
2-naphthalenol, 1-(2-(2,5-dimethoxyphenyl)diazenyl)-
unii-2qe5y68984
cerven rozpoustedlova 80
citrus red 2 [mi]
citrus red 2 [mart.]
citrus red 2 [hsdb]
e-121
citrus red no. 2 [iarc]
CHEBI:82306
SCHEMBL1486044
1-[(2,5-dimethoxyphenyl)diazenyl]-2-naphthol #
GJUABKCEXOMRPQ-FMQUCBEESA-N
2,5-dimethoxybenzeneazo-.beta.-naphthol
2-naphthalenol, 1-[(2,5-dimethoxyphenyl)azo]-
NCGC00357148-01
dtxsid6024838 ,
dtxcid10809925
tox21_303891
cas-6358-53-8
CHEMBL3560990
AKOS028109059
citrus red 2, analytical standard
1-[(2,5-dimethoxyphenyl)azo]-2-naphthol
1-(2-(2,5-dimethoxyphenyl)diazenyl)-2-naphthalenol
1-[(2,5-dimethoxyphenyl)azo]-2-naphthalenol, 9ci
1-[(2,5-dimethoxyphenyl)azo]-2-naphthalenol
1-[(2,5-dimethoxyphenyl)diazenyl]naphthalen-2-ol
1-(2,5-dimethoxy-phenylazo)-2-naphthol
Q2653981
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (19)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
LuciferasePhotinus pyralis (common eastern firefly)Potency6.32610.007215.758889.3584AID1224835
acetylcholinesteraseHomo sapiens (human)Potency35.57420.002541.796015,848.9004AID1347399
hypoxia-inducible factor 1 alpha subunitHomo sapiens (human)Potency48.96623.189029.884159.4836AID1224846
RAR-related orphan receptor gammaMus musculus (house mouse)Potency1.47380.006038.004119,952.5996AID1159521; AID1159523
SMAD family member 2Homo sapiens (human)Potency2.18720.173734.304761.8120AID1346924
SMAD family member 3Homo sapiens (human)Potency2.18720.173734.304761.8120AID1346924
GLI family zinc finger 3Homo sapiens (human)Potency48.55770.000714.592883.7951AID1259369
AR proteinHomo sapiens (human)Potency67.29850.000221.22318,912.5098AID1259243; AID1259247
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency6.47490.001022.650876.6163AID1224838; AID1224839; AID1224893
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency5.85740.003041.611522,387.1992AID1159552; AID1159555
retinoid X nuclear receptor alphaHomo sapiens (human)Potency4.63040.000817.505159.3239AID1159527; AID1159531
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency67.72880.001530.607315,848.9004AID1224841; AID1224842; AID1259401
pregnane X nuclear receptorHomo sapiens (human)Potency9.68850.005428.02631,258.9301AID1346982
estrogen nuclear receptor alphaHomo sapiens (human)Potency8.63490.000229.305416,493.5996AID1259244; AID1259248
thyroid stimulating hormone receptorHomo sapiens (human)Potency57.80670.001628.015177.1139AID1259385; AID1259395
v-jun sarcoma virus 17 oncogene homolog (avian)Homo sapiens (human)Potency20.68310.057821.109761.2679AID1159526; AID1159528
histone deacetylase 9 isoform 3Homo sapiens (human)Potency27.84010.037617.082361.1927AID1259364; AID1259388
Voltage-dependent calcium channel gamma-2 subunitMus musculus (house mouse)Potency8.63490.001557.789015,848.9004AID1259244
Glutamate receptor 2Rattus norvegicus (Norway rat)Potency8.63490.001551.739315,848.9004AID1259244
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
plasma membraneGlutamate receptor 2Rattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (40.00)24.3611
2020's2 (40.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 33.57

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index33.57 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index42.09 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (33.57)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]