Page last updated: 2024-12-09

cis-isrib

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID1011240
CHEMBL ID4303573
SCHEMBL ID16082980
SCHEMBL ID16083047
SCHEMBL ID16082988
MeSH IDM000607381

Synonyms (66)

Synonym
STK435431
n,n'-cyclohexane-1,4-diylbis[2-(4-chlorophenoxy)acetamide]
OPREA1_706389
2-(4-chlorophenoxy)-n-[4-[[2-(4-chlorophenoxy)acetyl]amino]cyclohexyl]acetamide
AKOS003300916
S7400
isrib (trans-isomer)
c22h24cl2n2o4
isrib
SCHEMBL16082980
SCHEMBL16083047
SCHEMBL16082988
1597403-47-8
trans-isrib
AKOS025142075
n,n'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide]
AC-35228
n,n'-((1r,4r)-cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide)
548470-11-7
J-690321
EX-A298
2-(4-chlorophenoxy)-n-{4-[2-(4-chlorophenoxy)acetamido]cyclohexyl}acetamide
2-(4-chlorophenoxy)-n-[(1r,4r)-4-[2-(4-chlorophenoxy)acetamido]cyclohexyl]acetamide
trans-isomer
isrib trans-isomer
mfcd27952932
isrib, >=98% (hplc)
NCGC00389802-01
AKOS030633038
n,n'-(cis-cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide)
1597403-48-9
C7B ,
2-(4-chloranylphenoxy)-~{n}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide
BCP23947
n,n'-(cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide)
FT-0700328
cis-isrib
mfcd30730068
DS-19940
AS-16593
BCP10786
cis-isrib;isrib
isrib (cis-isomer)
A14302
n,n'-(trans-cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide)
acetamide, n,n'-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)-
NCGC00384174-11
HMS3887M19
n,n'-(cis-cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide
CCG-269245
CHEMBL4303573
C73020
A897811
n,n'-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide]
isrib(trans-isomer)
AS-55833
XNC40347
XNC40348
CS-0187553
S0706
trans-n,n'-(cyclohexane-1,4-diyl)bis(2-(4-chlorophenoxy)acetamide)
A899328
2-(4-chlorophenoxy)-n-[(1s,4s)-4-[2-(4-chlorophenoxy)acetamido]cyclohexyl]acetamide
DTXSID601045380
HY-12495A
CS-0029263

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
"The ATP-binding cassette transporter P-glycoprotein (P-gp) is known to limit both brain penetration and oral bioavailability of many chemotherapy drugs."( A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Ambudkar, SV; Brimacombe, KR; Chen, L; Gottesman, MM; Guha, R; Hall, MD; Klumpp-Thomas, C; Lee, OW; Lee, TD; Lusvarghi, S; Robey, RW; Shen, M; Tebase, BG, 2019
)
0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (7)

Assay IDTitleYearJournalArticle
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347160Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347159Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (40.00)24.3611
2020's3 (60.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.72 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.72)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]