cincreasin: small-molecule inhibitor of Mps1 that blocks the spindle-checkpoint response to a lack of tension on mitotic chromosomes; named cincreasin for chromosome instability increasing compound; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
cincreasin : A member of the class of benzoxazoles that is 2-benzoxazolinone substituted at position 6 by a bromo group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]
| ID Source | ID |
|---|---|
| PubMed CID | 29859 |
| CHEMBL ID | 1898381 |
| CHEBI ID | 77861 |
| SCHEMBL ID | 1762301 |
| MeSH ID | M0489778 |
| Synonym |
|---|
| EN300-37479 |
| 6-bromo-2,3-dihydro-1,3-benzoxazol-2-one |
| 6-bromo-2-benzoxazolinone |
| nsc26190 |
| nsc-26190 |
| cincreasin |
| mls002639099 , |
| 2-benzoxazolinone, 6-bromo- |
| 2(3h)-benzoxazolone, 6-bromo- |
| 19932-85-5 |
| brn 0135506 |
| nsc 26190 |
| 6-bromobenzoksazolinon-2 [polish] |
| smr001548550 |
| AKOS003388134 |
| 6-bromo-3h-1,3-benzoxazol-2-one |
| 6-bromo-1,3-benzoxazol-2(3h)-one |
| STK802473 |
| 6-bromobenzo[d]oxazol-2(3h)-one |
| HMS3080E07 |
| 6-bromobenzoksazolinon-2 |
| BP-20118 |
| FT-0647611 |
| HD-0708 |
| 6-bromo-1,3-benzoxazol-2-ol |
| STL273089 |
| AKOS016402889 |
| SCHEMBL1762301 |
| 6-bromo-3h-benzoxazol-2-one |
| 6-bromobenzoxazolinone |
| 6-bromo-3h-benzooxazol-2-one |
| 6-bromo-2(3h)-benzoxazolone |
| CHEBI:77861 , |
| 6-bromo benzoxazolinone |
| DDNKJFBQMQOIKI-UHFFFAOYSA-N |
| CHEMBL1898381 |
| 6-bromo-benzoxazolinone |
| AC-30754 |
| 6-bromobenzoxazol-2(3h)-one |
| B5290 |
| DTXSID70173710 |
| mfcd00694727 |
| J-518423 |
| 6-bromo-2-benzoxazolinone, 97% |
| J-012872 |
| 6-bromobenzoxazolone |
| Q27147469 |
| SY038492 |
| CS-W022467 |
| 6-bromo-2-hydroxybenzoxazole |
| 6-bromo-2-benzoxazolone |
| BCP26435 |
| 6-bromo-2-hydroxybenzo[d]oxazole |
| Z381351238 |
| Class | Description |
|---|---|
| benzoxazole | Compounds based on a fused 1,2- or 1,3-oxazole and benzene bicyclic ring skeleton. |
| organobromine compound | A compound containing at least one carbon-bromine bond. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| USP1 protein, partial | Homo sapiens (human) | Potency | 44.6684 | 0.0316 | 37.5844 | 354.8130 | AID743255 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 100.0000 | 0.0501 | 27.0736 | 89.1251 | AID588590 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.56) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||