Compounds > cicloxilic acid
Page last updated: 2024-12-06

cicloxilic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

cicloxilic acid: RN given refers to (cis)-isomer; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

cicloxilic acid : A racemate comprising equal amounts of (1R,2S)- and (1S,2R)-cicloxilic acid. It is a choleretic agent that has antilithogenic activity. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

(1S,2R)-cicloxilic acid : A 2-hydroxy-2-phenylcyclohexanecarboxylic acid that has (1S,2R)-stereoconfiguration. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID68776
CHEMBL ID4747495
CHEBI ID157630
SCHEMBL ID866481
MeSH IDM0070857

Synonyms (39)

Synonym
einecs 260-966-6
cis-2-hydroxy-2-phenylcyclohexanecarboxylic acid
cis-2-hidroxi-2-fenilciclohexanocarboxilico acido [italian]
plecton
acidum cicloxilicum [inn-latin]
acido cicloxilico [inn-spanish]
cyclohexanecarboxylic acid, 2-hydroxy-2-phenyl-, cis-
cicloxilic acid [inn]
cicloxilic acid
cicloxilico acido [spanish]
acide cicloxilique [inn-french]
acido ciclossilico [dcit]
CHEBI:157630
(1s,2r)-2-hydroxy-2-phenylcyclohexane-1-carboxylic acid
(1s,2r)-cicloxilic acid
(1s,2r)-2-hydroxy-2-phenylcyclohexanecarboxylic acid
2alpha-hydroxy-2-phenylcyclohexane-1alpha-carboxylic acid
57808-63-6
A831616
cicloxilico acido
acide cicloxilique
cis-2-hidroxi-2-fenilciclohexanocarboxilico acido
acido cicloxilico
unii-18wj167mzn
acido ciclossilico
18wj167mzn ,
acidum cicloxilicum
AKOS015899814
cicloxilic acid [who-dd]
cicloxilic acid [mart.]
SCHEMBL866481
mfcd06654088
CS-7290
HY-U00305
Q4726996
AS-79740
DTXSID701024145
CHEMBL4747495
E85634

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
2-hydroxy-2-phenylcyclohexanecarboxylic acidA member of the class of cyclohexanols that is cyclohexane substituted by carboxy, hydroxy and phenyl groups at positions 1, 2 and 2, respectively.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-199010 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 63.41

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index63.41 (24.57)
Research Supply Index2.77 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index206.92 (26.88)
Search Engine Supply Index4.00 (0.95)

This Compound (63.41)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials3 (25.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies1 (8.33%)4.05%
Observational0 (0.00%)0.25%
Other8 (66.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ethinyl estradiol
Ethinyl Estradiol: A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.. 17alpha-ethynylestradiol : A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.		1.961017-hydroxy steroid;
3-hydroxy steroid;
terminal acetylenic compound		xenoestrogen
arginine
Arginine: An essential amino acid that is physiologically active in the L-form.. arginine : An alpha-amino acid that is glycine in which the alpha-is substituted by a 3-guanidinopropyl group.		2.3620arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical
thiazoles
[no description available]		2.36201,3-thiazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
thiazolidines
Thiazolidines: Reduced (protonated) form of THIAZOLES. They can be oxidized to THIAZOLIDINEDIONES.		2.3620thiazolidine
caprylates
Caprylates: Derivatives of caprylic acid. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a carboxy terminated eight carbon aliphatic structure.. octanoate : A straight-chain saturated fatty acid anion that is the conjugate base of octanoic acid (caprylic acid); believed to block adipogenesis.		1.9610fatty acid anion 8:0;
straight-chain saturated fatty acid anion		human metabolite;
Saccharomyces cerevisiae metabolite
monooctanoin
monooctanoin: dissolution agent for retained cholesterol bile duct stones; RN in Chemline for octanoic acid, ester with 1,2,3-propanetriol, MF unknown: 11140-04-8; RN for octanoic acid, 2,3-dihydroxypropyl ester (1-monooctanoin): 502-54-5; RN in 9th CI Form Index for (+-)-1-monooctanoin: 19670-49-6. rac-1-monooctanoylglycerol : A rac-1-monoacylglycerol comprising equal amounts of 1-octanoyl-sn-glycerol and 3-octanoyl-sn-glycerol.. 1-monooctanoylglycerol : A 1-monoglyceride that has octanoyl as the acyl group.		6.96101-monoglyceride;
octanoate ester;
rac-1-monoacylglycerol
arginine thiazolidinecarboxylate
arginine thiazolidinecarboxylate: prophylactic against galactosamine hepatotoxicity; thiazolidinecarboxylate salt of arginine		2.3620
ceruletide
Ceruletide: A specific decapeptide obtained from the skin of Hila caerulea, an Australian amphibian. Caerulein is similar in action and composition to CHOLECYSTOKININ. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction.. ceruletide : A decapeptide comprising 5-oxoprolyl, glutamyl, aspartyl, O-sulfotyrosyl, threonyl, glycyl, tryptopyl, methionyl, aspartyl and phenylalaninamide residues in sequence. Found in the skins of certain Australian amphibians, it is an analogue of the gastrointestinal peptide hormone cholecystokinin and stimulates gastric, biliary, and pancreatic secretion. It is used in cases of paralysis of the intestine (paralytic ileus) and as a diagnostic aid in pancreatic malfunction.		3.3511oligopeptidediagnostic agent;
gastrointestinal drug
phosphatidylcholines
Phosphatidylcholines: Derivatives of PHOSPHATIDIC ACIDS in which the phosphoric acid is bound in ester linkage to a CHOLINE moiety.		2.65301,2-diacyl-sn-glycero-3-phosphocholine
ConditionIndicatedRelationship StrengthStudiesTrials
Gallstone Disease
[description not available]		03.3511
Cholelithiasis
Presence or formation of GALLSTONES in the BILIARY TRACT, usually in the gallbladder (CHOLECYSTOLITHIASIS) or the common bile duct (CHOLEDOCHOLITHIASIS).		03.3511
Bile Duct Obstruction, Extrahepatic
[description not available]		01.9610
Bile Duct Obstruction
[description not available]		01.9610
Cholestasis
Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).		06.9610
Acute Liver Injury, Drug-Induced
[description not available]		03.3411
Liver Dysfunction
[description not available]		04.322
Liver Diseases
Pathological processes of the LIVER.		04.322
Chemical and Drug Induced Liver Injury
A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.		03.3411
Alcoholic Liver Diseases
[description not available]		02.3620
Liver Diseases, Alcoholic
Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS.		02.3620
Indigestion
[description not available]		03.3411
Dyspepsia
Impaired digestion, especially after eating.		03.3411
Biliary Calculi
[description not available]		01.9610
Gallstones
Solid crystalline precipitates in the BILIARY TRACT, usually formed in the GALLBLADDER, resulting in the condition of CHOLELITHIASIS. Gallstones, derived from the BILE, consist mainly of calcium, cholesterol, or bilirubin.		01.9610