chrodrimanin B: an insecticidal meroterpene that blocks GABA-gated chloride channels; isolated from Talaromyces; structure in first source [MeSH]
chrodrimanin B : no description available [CHeBI]
| ID Source | ID |
|---|---|
| PubMed CID | 101565496 |
| CHEMBL ID | 3581316 |
| CHEBI ID | 156420 |
| MeSH ID | M000613720 |
| Synonym |
|---|
| CHEBI:156420 |
| chrodrimanin b |
| CHEMBL3581316 |
| NCGC00385361-01 |
| (1r,2r,7ar,8s,9ar,13as,13bs)-1-(acetyloxy)-1,8,9,9a,10,13a,13b,14-octahydro-5,8-dihydroxy-2,7a,10,10,13a-pentamethyl-2h,4h-benzo[a]pyrano[3,4-j]xanthene-4,11(7ah)-dione |
| [(1s,5r,6r,14r,15s,17r,22s)-10,15-dihydroxy-6,14,18,18,22-pentamethyl-8,19-dioxo-7,13-dioxapentacyclo[12.8.0.03,12.04,9.017,22]docosa-3(12),4(9),10,20-tetraen-5-yl] acetate |
| 132196-54-4 |
| CS-0144645 |
| HY-N8472 |
| AKOS040736007 |
| Class | Description |
|---|---|
| organic heteropentacyclic compound |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1296008 | Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening | 2020 | SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1 ISSN: 2472-5560 | Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening. |
| AID1347160 | Primary screen NINDS Rhodamine qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1346986 | P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 ISSN: 1521-0111 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1346987 | P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen | 2019 | Molecular pharmacology, 11, Volume: 96, Issue:5 ISSN: 1521-0111 | A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. |
| AID1347159 | Primary screen GU Rhodamine qHTS for Zika virus inhibitors: Unlinked NS2B-NS3 protease assay | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 ISSN: 1091-6490 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1229766 | Antibacterial activity against Staphylococcus aureus | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 ISSN: 1520-6025 | Chrodrimanins I and J from the Antarctic Moss-Derived Fungus Penicillium funiculosum GWT2-24. |
| AID1229768 | Antiviral activity against influenza A virus (A/Puerto Rico/8/34(H1N1)) infected in MDCK cells incubated for 48 hrs assessed as inhibition of virus-induced cytopathic effect by crystal violet staining assay | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 ISSN: 1520-6025 | Chrodrimanins I and J from the Antarctic Moss-Derived Fungus Penicillium funiculosum GWT2-24. |
| AID1238549 | Inhibition of PTP1B (unknown origin) at 20.7 uM | 2015 | Bioorganic & medicinal chemistry letters, Aug-15, Volume: 25, Issue:16 ISSN: 1464-3405 | Verruculides A and B, two new protein tyrosine phosphatase 1B inhibitors from an Indonesian ascidian-derived Penicillium verruculosum. |
| AID1229764 | Cytotoxicity against human HeLa cells by sulforhodamine B assay | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 ISSN: 1520-6025 | Chrodrimanins I and J from the Antarctic Moss-Derived Fungus Penicillium funiculosum GWT2-24. |
| AID1229767 | Antibacterial activity against Escherichia coli | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 ISSN: 1520-6025 | Chrodrimanins I and J from the Antarctic Moss-Derived Fungus Penicillium funiculosum GWT2-24. |
| AID1229762 | Cytotoxicity against human K562 cells by sulforhodamine B assay | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 ISSN: 1520-6025 | Chrodrimanins I and J from the Antarctic Moss-Derived Fungus Penicillium funiculosum GWT2-24. |
| AID1229763 | Cytotoxicity against human HL60 cells by sulforhodamine B assay | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 ISSN: 1520-6025 | Chrodrimanins I and J from the Antarctic Moss-Derived Fungus Penicillium funiculosum GWT2-24. |
| AID1229765 | Cytotoxicity against human A549 cells by sulforhodamine B assay | 2015 | Journal of natural products, Jun-26, Volume: 78, Issue:6 ISSN: 1520-6025 | Chrodrimanins I and J from the Antarctic Moss-Derived Fungus Penicillium funiculosum GWT2-24. |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 3 (33.33) | 2.80 |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 9 (100.00%) | 84.16% |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| oleanolic acid | hydroxy monocarboxylic acid; pentacyclic triterpenoid | plant metabolite | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | |
| ribavirin | 1-ribosyltriazole; aromatic amide; monocarboxylic acid amide; primary carboxamide | anticoronaviral agent; antiinfective agent; antimetabolite; antiviral agent; EC 2.7.7.49 (RNA-directed DNA polymerase) inhibitor | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Substance | Studies | Classes | Roles | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| gamma-aminobutyric acid | amino acid zwitterion; gamma-amino acid; monocarboxylic acid | human metabolite; neurotransmitter; Saccharomyces cerevisiae metabolite; signalling molecule | 2015 | 2022 | 5.5 | medium | 0 | 0 | 0 | 0 | 1 | 1 | |
| fipronil | (trifluoromethyl)benzenes; dichlorobenzene; nitrile; primary amino compound; pyrazoles; sulfoxide | 2015 | 2015 | 9.0 | low | 0 | 0 | 0 | 0 | 1 | 0 | ||
| muscimol | alkaloid; isoxazoles; primary amino compound | fungal metabolite; GABA agonist; oneirogen; psychotropic drug | 2022 | 2022 | 2.0 | low | 0 | 0 | 0 | 0 | 0 | 1 | |
| sesquiterpenes | 2012 | 2022 | 7.2 | high | 0 | 0 | 0 | 0 | 3 | 1 | |||
| warfarin | benzenes; hydroxycoumarin; methyl ketone | 2012 | 2012 | 12.0 | low | 0 | 0 | 0 | 0 | 1 | 0 |
| Condition | Indicated | Studies | First Year | Last Year | Average Age | Relationship Strength | Trials | pre-1990 | 1990's | 2000's | 2010's | post-2020 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Congenital Zika Syndrome | 0 | 2020 | 2020 | 4.0 | high | 0 | 0 | 0 | 0 | 1 | 0 | |
| Disease Models, Animal | 0 | 2020 | 2020 | 4.0 | high | 0 | 0 | 0 | 0 | 1 | 0 | |
| Zika Virus Infection | 0 | 2020 | 2020 | 4.0 | high | 0 | 0 | 0 | 0 | 1 | 0 |
| Article | Year |
|---|---|
| A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology, , Volume: 96, Issue:5 | 2019 |