Page last updated: 2024-12-07

cholesterylamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Cholesterylamine is a bile acid sequestrant medication used to lower cholesterol levels in the blood. It works by binding to bile acids in the gut, preventing their reabsorption and promoting their excretion. This leads to increased synthesis of bile acids from cholesterol in the liver, thereby lowering cholesterol levels. Cholesterylamine is typically used in combination with other cholesterol-lowering therapies, such as statins. It has been studied extensively for its effects on cholesterol metabolism and cardiovascular health. Cholesterylamine is typically synthesized through a series of chemical reactions involving a variety of starting materials and reagents. The compound is then purified and formulated into a suitable dosage form for administration.'

cholesterylamine: RN given refers to (3beta)-isomer; RN for cpd without isomeric designation not avail 3/92 [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID91512
CHEMBL ID2420594
SCHEMBL ID132651
MeSH IDM0197164

Synonyms (16)

Synonym
2126-93-4
choleslerylamine
(3s,8s,9s,10r,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-amine
cholesterylamine
CHEMBL2420594
cholest-5-en-3-amine, (3beta)-
3beta-aminocholesterol
YGPZWPHDULZYFR-DPAQBDIFSA-N
3beta-amino-5-cholestene
SCHEMBL132651
cholesterylamin
DTXSID60943681
cholest-5-en-3-amine
E79480
CS-0522303
HY-W409806
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (7)

Assay IDTitleYearJournalArticle
AID766995Cytotoxicity against MDCK2 cells assessed as maximum tolerated concentration by lactate dehydrogenase release assay2013Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18
Evaluation of steroidal amines as lipid raft modulators and potential anti-influenza agents.
AID766992Antiviral activity against Influenza A/PR8/34 (H1N1) virus infected in MDCK2 cells assessed as inactivation of virus by virucidal assay relative to control2013Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18
Evaluation of steroidal amines as lipid raft modulators and potential anti-influenza agents.
AID766994Therapeutic index, ratio of MTD for MDCK2 cells to IC50 for Influenza A/PR8/34 (H1N1) virus2013Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18
Evaluation of steroidal amines as lipid raft modulators and potential anti-influenza agents.
AID766996Antiviral activity against Influenza A/PR8/34 (H1N1) virus infected in MDCK2 cells assessed as inhibition of virus reproduction by ELISA2013Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18
Evaluation of steroidal amines as lipid raft modulators and potential anti-influenza agents.
AID766993Antiviral activity against Influenza A/PR8/34 (H1N1) virus infected in MDCK2 cells assessed as inhibition of virus budding by ELISA relative to control2013Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18
Evaluation of steroidal amines as lipid raft modulators and potential anti-influenza agents.
AID766991Antiviral activity against Influenza A/PR8/34 (H1N1) virus infected in MDCK2 cells assessed as raft modulation using perylene as tracer relative to control2013Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18
Evaluation of steroidal amines as lipid raft modulators and potential anti-influenza agents.
AID766990Antiviral activity against Influenza A/PR8/34 (H1N1) virus infected in MDCK2 cells assessed as raft modulation using N-terminally sterol-linked peptide as tracer relative to control2013Bioorganic & medicinal chemistry letters, Sep-15, Volume: 23, Issue:18
Evaluation of steroidal amines as lipid raft modulators and potential anti-influenza agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (10.00)18.7374
1990's1 (10.00)18.2507
2000's7 (70.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 94.28

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index94.28 (24.57)
Research Supply Index2.40 (2.92)
Research Growth Index5.10 (4.65)
Search Engine Demand Index163.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (94.28)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other8 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]