chlorodiethylenetriamine platinum profile

Chlorodiethylenetriamine platinum (also known as CHIP) is a platinum-based anticancer drug that has shown promising activity against various types of cancer, particularly ovarian cancer. It is synthesized through a multi-step process involving the reaction of potassium tetrachloroplatinate(II) with diethylenetriamine. CHIP exerts its anticancer effects by binding to DNA, inhibiting its replication and transcription, ultimately leading to cell death. The compound is particularly effective in targeting tumors that have developed resistance to conventional platinum-based drugs like cisplatin. Research on CHIP focuses on understanding its mechanism of action, optimizing its delivery methods, and exploring its potential use in combination therapies. The compound's ability to overcome drug resistance and its relatively low toxicity profile make it a promising candidate for future cancer treatments.'

chlorodiethylenetriamine platinum: RN given refers to parent cpd; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	107836
MeSH ID	M0102052

Synonym
chloro(diethylenetriammine)platinum(ii) chloride
chloro(diethylenetriamine)platinum(ii) chloride
diethylenetriamminechloroplatinum chloride
diethylenetriaminechloroplatinum(ii) chloride
platinum(1+), chloro(diethylenetriamine)-, chloride
monodentate chloro(diethylenetriamine)platinum(ii) chloride
platinum(1+), (n-(2-(amino-kappan)ethyl)-1,2-ethanediamine-kappan,kappan')chloro-, chloride, (sp-4-2)-
chlorodiethylenetriamine platinum
platinum(1+), (n-(2-aminoethyl)-1,2-ethanediamine-n,n')chloro-, chloride, (sp-4-2)-
chlorodiethylenetriamineplatinum(ii)chloride
14215-58-8
bis(2-azanidylethyl)azanide;platinum(4+);chloride

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	14 (48.28)	18.7374
1990's	10 (34.48)	18.2507
2000's	4 (13.79)	29.6817
2010's	1 (3.45)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	30 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
chloroacetaldehyde [no description available]	1.98	1	organochlorine compound
acetaldehyde Acetaldehyde: A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.. acetaldehyde : The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke.. aldehyde : A compound RC(=O)H, in which a carbonyl group is bonded to one hydrogen atom and to one R group.. acetyl group : A group, formally derived from acetic acid by dehydroxylation, which is fundamental to the biochemistry of all forms of life. When bound to coenzyme A, it is central to the metabolism of carbohydrates and fats.	1.98	1	aldehyde	carcinogenic agent; EC 3.5.1.4 (amidase) inhibitor; electron acceptor; Escherichia coli metabolite; human metabolite; mouse metabolite; mutagen; oxidising agent; Saccharomyces cerevisiae metabolite; teratogenic agent
adenine [no description available]	2.03	1	6-aminopurines; purine nucleobase	Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
chlorine chloride : A halide anion formed when chlorine picks up an electron to form an an anion.	2	1	halide anion; monoatomic chlorine	cofactor; Escherichia coli metabolite; human metabolite
thymine [no description available]	2.03	1	pyrimidine nucleobase; pyrimidone	Escherichia coli metabolite; human metabolite; mouse metabolite
ethidium Ethidium: A trypanocidal agent and possible antiviral agent that is widely used in experimental cell biology and biochemistry. Ethidium has several experimentally useful properties including binding to nucleic acids, noncompetitive inhibition of nicotinic acetylcholine receptors, and fluorescence among others. It is most commonly used as the bromide.. ethidium : The fluorescent compound widely used in experimental cell biology and biochemistry to reveal double-stranded DNA and RNA.	6.96	1	phenanthridines	fluorochrome; intercalator
piperidine [no description available]	1.98	1	azacycloalkane; piperidines; saturated organic heteromonocyclic parent; secondary amine	base; catalyst; human metabolite; non-polar solvent; plant metabolite; protic solvent; reagent
platinum Platinum: A heavy, soft, whitish metal, resembling tin, with atomic number 78, atomic weight 195.084, symbol Pt. It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as alutiae.	2.91	4	elemental platinum; nickel group element atom; platinum group metal atom
mercuric chloride Mercuric Chloride: Mercury chloride (HgCl2). A highly toxic compound that volatizes slightly at ordinary temperature and appreciably at 100 degrees C. It is corrosive to mucous membranes and used as a topical antiseptic and disinfectant.. mercury dichloride : A mercury coordination entity made up of linear triatomic molecules in which a mercury atom is bonded to two chlorines. Water-soluble, it is highly toxic. Once used in a wide variety of applications, including preserving wood and anatomical specimens, embalming and disinfecting, as an intensifier in photography, as a mordant for rabbit and beaver furs, and freeing gold from lead, its use has markedly declined as less toxic alternatives have been developed.	1.99	1	mercury coordination entity	sensitiser
adenylyl imidodiphosphate Adenylyl Imidodiphosphate: 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid. An analog of ATP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It is a potent competitive inhibitor of soluble and membrane-bound mitochondrial ATPase and also inhibits ATP-dependent reactions of oxidative phosphorylation.	2.03	1	adenosine 5'-phosphate
chloroterpyridineplatinum(ii) [no description available]	2.04	1
carboplatin [no description available]	2.01	1
glycosides [no description available]	1.97	1
oligonucleotides [no description available]	2	1
piperidines Piperidines: A family of hexahydropyridines.	1.98	1

Condition	Relationship Strength	Studies
ALS - Amyotrophic Lateral Sclerosis [description not available]	1.96	1
Colitis, Granulomatous [description not available]	1.96	1
Autoimmune Demyelinating Disease, Peripheral [description not available]	1.96	1
Amyotrophic Lateral Sclerosis A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)	1.96	1
Crohn Disease A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.	1.96	1
Infections, Chlamydia [description not available]	1.98	1
Infections, Ureaplasma [description not available]	1.98	1
Chlamydia Infections Infections with bacteria of the genus CHLAMYDIA.	1.98	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	1.98	1
Experimental Neoplasms [description not available]	1.97	1

chlorodiethylenetriamine platinum

Description

Cross-References

Synonyms (12)

Research

Studies (29)

Market Indicators

Research Demand Index: 10.66

Study Types