Compounds > chivosazol a
Page last updated: 2024-11-13

chivosazol a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

chivosazol A: isolated from Sorangium cellulosum; active against fungi and yeast; a macrocyclic ring with one oxazole ring and a quinovose at C-11; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID155542930
CHEMBL ID4522174
MeSH IDM0254171

Synonyms (3)

Synonym
CHEMBL4522174 ,
bdbm50508924
chivosazol a
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Actin, alpha skeletal muscleOryctolagus cuniculus (rabbit)IC50 (µMol)15.21008.47008.47008.4700AID1538798
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID1538804Induction of morphological changes in human HUVEC cells assessed as disruption of F-actin fibers at 10 nM to 100 nM incubated for 1 hr by rhodamine-phalloidin staining based fluorescence assay2019Journal of natural products, 07-26, Volume: 82, Issue:7
Chivosazole A Modulates Protein-Protein Interactions of Actin.
AID1538803Induction of rabbit skeletal muscle alpha-actin depolymerization assessed as destabilization of F-actin 5 uM measured every 15 sec for 90 mins in presence of Turkey gizzard alpha-actinin and Atto448 fluorescent labelled actin by TIRF microscopy analysis2019Journal of natural products, 07-26, Volume: 82, Issue:7
Chivosazole A Modulates Protein-Protein Interactions of Actin.
AID1538801Inhibition of rabbit skeletal muscle alpha-actin nucleation at 500 nM to 5 uM in presence of Turkey gizzard alpha-actinin and Atto448 fluorescent labelled actin by TIRF microscopy analysis2019Journal of natural products, 07-26, Volume: 82, Issue:7
Chivosazole A Modulates Protein-Protein Interactions of Actin.
AID1538805Induction of morphological changes in human HUVEC cells assessed as amorphous actin aggregation in nucleus incubated for 1 hr by Hoechst staining based fluorescence assay2019Journal of natural products, 07-26, Volume: 82, Issue:7
Chivosazole A Modulates Protein-Protein Interactions of Actin.
AID1538799Antiproliferative activity against human HUVEC measured after 72 hrs2019Journal of natural products, 07-26, Volume: 82, Issue:7
Chivosazole A Modulates Protein-Protein Interactions of Actin.
AID1538802Inhibition of rabbit skeletal muscle alpha-actin polymerization induced by Mg-ATP assessed as decrease in elongation rate at 500 nM to 5 uM measured every 1 sec for 5 mins in presence of Turkey gizzard alpha-actinin and Atto448 fluorescent labelled actin 2019Journal of natural products, 07-26, Volume: 82, Issue:7
Chivosazole A Modulates Protein-Protein Interactions of Actin.
AID1538808Inhibition of immobilized rabbit skeletal muscle alpha-actin interaction with profilin at 66.7 uM pretreated for 30 mins followed by profilin addition measured after 1 hr by pull-down assay2019Journal of natural products, 07-26, Volume: 82, Issue:7
Chivosazole A Modulates Protein-Protein Interactions of Actin.
AID1538798Inhibition of rabbit skeletal muscle alpha-actin polymerization measured after 24 hrs in presence of ATP and fluorescent pyrene-labelled actin by fluorescence based assay2019Journal of natural products, 07-26, Volume: 82, Issue:7
Chivosazole A Modulates Protein-Protein Interactions of Actin.
AID1538810Binding affinity to immobilized rabbit skeletal muscle alpha-actin assessed as formation of G-actin dimers at 40 uM and pH 6.8 to 8 treated for 30 mins in absence of thymosin-beta4 by size-exclusion chromatography2019Journal of natural products, 07-26, Volume: 82, Issue:7
Chivosazole A Modulates Protein-Protein Interactions of Actin.
AID1538809Inhibition of immobilized rabbit skeletal muscle alpha-actin interaction with thymosin-beta4 at 40 uM pretreated for 30 mins followed by thymosin-beta4 addition measured after 45 mins by cross-linking assay2019Journal of natural products, 07-26, Volume: 82, Issue:7
Chivosazole A Modulates Protein-Protein Interactions of Actin.
AID1538800Inhibition of cell migration in human HUVEC cells assessed as decrease in cell velocity measured after 16 hrs by crystal violet staining based scratch assay2019Journal of natural products, 07-26, Volume: 82, Issue:7
Chivosazole A Modulates Protein-Protein Interactions of Actin.
AID1538812Binding affinity to immobilized rabbit skeletal muscle alpha-actin assessed change in retention time of G-actin dimers at 40 uM and pH 6.8 to 8 treated for 30 mins in absence of thymosin-beta4 by size-exclusion chromatography2019Journal of natural products, 07-26, Volume: 82, Issue:7
Chivosazole A Modulates Protein-Protein Interactions of Actin.
AID1538806Inhibition of immobilized rabbit skeletal muscle alpha-actin interaction with cofilin at 56 uM pretreated for 30 mins followed by cofilin addition measured after 1 hr by pull-down assay2019Journal of natural products, 07-26, Volume: 82, Issue:7
Chivosazole A Modulates Protein-Protein Interactions of Actin.
AID1538807Inhibition of immobilized rabbit skeletal muscle alpha-actin interaction with gelsolin at 12.5 uM pretreated for 30 mins followed by gelsolin addition measured after 1 hr by pull-down assay2019Journal of natural products, 07-26, Volume: 82, Issue:7
Chivosazole A Modulates Protein-Protein Interactions of Actin.
AID1538811Inhibition of immobilized rabbit skeletal muscle alpha-actin interaction with thymosin-beta4 assessed as decrease in cross-linked complex formation at 40 uM pretreated for 30 mins followed by thymosin-beta4 addition measured after 45 mins by cross-linking2019Journal of natural products, 07-26, Volume: 82, Issue:7
Chivosazole A Modulates Protein-Protein Interactions of Actin.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (6.67)18.2507
2000's11 (73.33)29.6817
2010's3 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
colchicine
(S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.		2.0510alkaloid;
colchicine		anti-inflammatory agent;
gout suppressant;
mutagen
oxazoles
Oxazoles: Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.. 1,3-oxazole : A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.. oxazole : An azole based on a five-membered heterocyclic aromatic skeleton containing one N and one O atom.		1.98101,3-oxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
vinyl bromide
vinyl bromide: structure		2.0510bromoalkene;
monohaloethene
paclitaxel
Taxus: Genus of coniferous yew trees or shrubs, several species of which have medicinal uses. Notable is the Pacific yew, Taxus brevifolia, which is used to make the anti-neoplastic drug taxol (PACLITAXEL).		2.0510taxane diterpenoid;
tetracyclic diterpenoid		antineoplastic agent;
human metabolite;
metabolite;
microtubule-stabilising agent
latrunculin b
latrunculin B: 14-membered macrolide attached to 2-thiazolidinone moiety; from Red Sea sponge Latrunculia magnifica; see also latrunculin A; structure given in first source. latrunculin B : A macrolide consisting of a 14-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica.		2.2110cyclic hemiketal;
macrolide;
oxabicycloalkane;
thiazolidinone		actin polymerisation inhibitor;
metabolite;
toxin
chivosazole f
chivosazole F: from Sorangium cellulosum; structure in first source		2.4620oxazole
etnangien
etnangien: a macrolide-polyene antibiotic from Sorangium cellulosum that inhibits nucleic acid polymerases; structure in first source. etnangien : A macrolide antibiotic isolated from the culture broth of the myxobacterium Sorangium cellulosum and has been found to be active against Gram-positive bacteria.		2.0510hydroxy monocarboxylic acid;
macrolide antibiotic		antibacterial agent;
metabolite
blasticidin a
blasticidin A: an inhibitor of aflatoxin production by Aspergillus parasiticus; structure in first source		2.0510
cytochalasin d
Cytochalasin D: A fungal metabolite that blocks cytoplasmic cleavage by blocking formation of contractile microfilament structures resulting in multinucleated cell formation, reversible inhibition of cell movement, and the induction of cellular extrusion. Additional reported effects include the inhibition of actin polymerization, DNA synthesis, sperm motility, glucose transport, thyroid secretion, and growth hormone release.. cytochalasin D : An organic heterotricyclic compound that is a mycotoxin produced by Helminthosporium and other moulds which is cell permeable and a potent inhibitor of actin polymerisation and DNA synthesis.		2.0510
guanosine pentaphosphate
Guanosine Pentaphosphate: Guanosine 5'-triphosphate 2'(3')-diphosphate. A guanine nucleotide containing five phosphate groups. Three phosphate groups are esterified to the sugar moiety in the 5' position and the other two in the 2' or 3' position. This nucleotide serves as a messenger to turn off the synthesis of ribosomal RNA when amino acids are not available for protein synthesis.. guanosine 3'-diphosphate 5'-triphosphate : A guanosine bisphosphate having a diphosphate at the 3'-position and a triphosphate at the 5'-position.		2.0410guanosine 5'-phosphate;
guanosine bisphosphate		Escherichia coli metabolite;
mouse metabolite
ConditionIndicatedRelationship StrengthStudiesTrials