Chelocardin is a potent antibiotic produced by the bacterium Streptomyces This compound exhibits a unique mode of action by inhibiting bacterial RNA polymerase, a crucial enzyme involved in protein synthesis. Its unusual structure, characterized by a complex polycyclic ring system, has fascinated chemists and inspired research into its synthesis and modification. Chelocardin has shown promising activity against a wide range of bacteria, including multidrug-resistant strains, making it a potential lead compound for the development of new antibiotics. Due to its complex structure and its potent biological activity, chelocardin has been the subject of numerous studies aimed at understanding its biosynthesis, elucidating its mode of action, and exploring its potential therapeutic applications. The compound's ability to inhibit RNA polymerase, an essential enzyme in bacteria, makes it a valuable tool for studying the mechanism of bacterial transcription and for developing novel antibiotic drugs. '
chelocardin: RN given refers to (4R-(4alpha,4abeta,12abeta))-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 71402 |
| CHEMBL ID | 2110884 |
| SCHEMBL ID | 214148 |
| MeSH ID | M0040496 |
| Synonym |
|---|
| 2-decarboxamido-2-acetyl-4-desdimethylamino-4-amino-9-methyl-5a,6-anhydrotetracycline |
| cetocycline |
| cetocyline |
| chelocardin |
| 2-decarboxamido-2-acetyl-4-dedimethylamino-4-epiamino-9-methyl-5a,6-anhydrotetracycline |
| cetotetrine |
| 1,12-(4h,5h)-naphthacenedione, 2-acetyl-4-alpha-amino-4a-beta,12a-dihydro- 3,10,11,12a-beta-tetrahydroxy-6,9-dimethyl- |
| (1r,4ar,12as)-3-acetyl-1-amino-4,4a,6,7-tetrahydroxy-8,11-dimethyl-12,12a-dihydro-1h-tetracene-2,5-dione |
| 29144-42-1 |
| n09qlw5pxu , |
| cetocycline [inn] |
| unii-n09qlw5pxu |
| 1,12(4h,5h)-naphthacenedione, 2-acetyl-4-amino-4a,12a-dihydro-3,10,11,12a-tetrahydroxy-6,9-dimethyl-, (4r-(4.alpha.,4a.beta.,12a.beta.))- |
| .beta.-chelocardin |
| 1,12(4h,5h)-naphthacenedione, 2-acetyl-4.alpha.-amino-4a.beta.,12a-dihydro-3,10,11,12a.beta.-tetrahydroxy-6,9-dimethyl- |
| abbott-40728 free base |
| 1,12(4h,5h)-naphthacenedione, 2-acetyl-4-amino-4a,12a-dihydro-3,10,11,12a-tetrahydroxy-6,9-dimethyl-, (4r,4as,12as)- |
| tri-chelocardin |
| SCHEMBL214148 |
| CHEMBL2110884 |
| compound 1 [pmid: 379332] |
| gtpl10792 |
| a-40728 |
| Q27284343 |
| DTXSID50951750 |
| 3-acetyl-1-amino-4,4a,6,7-tetrahydroxy-8,11-dimethyl-12,12a-dihydrotetracene-2,5(1h,4ah)-dione |
| 53228-00-5 |
| rel-(4r,4as,12as)-2-acetyl-4-amino-4a,12a-dihydro-3,10,11,12a-tetrahydroxy-6,9-dimethyl-1,12(4h,5h)-naphthacenedione |
| DTXSID301023814 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 5 (38.46) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (19.12) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 1 (7.69%) | 5.53% |
| Reviews | 1 (7.69%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 11 (84.62%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||