Compounds > carsatrin
Page last updated: 2024-12-08

carsatrin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

carsatrin: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID193951
CHEMBL ID313458
SCHEMBL ID1229997
MeSH IDM0211190

Synonyms (17)

Synonym
CHEMBL313458
carsatrin
(2s)-1-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-3-(7h-purin-6-ylsulfanyl)propan-2-ol
JOMBZLFCXNSKEQ-UHFFFAOYSA-N
6-[1-[1-[bis(4-fluorophenyl)methyl]piperazin-4-yl]-2-hydroxy-3-propanylthio]purine
6-[1-[1-[bis(4-fluorophenyl)methyl]-piperazin-4-yl]-2-hydroxy-3-propanylthio]purine
125363-87-3
1-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-3-(7h-purin-6-ylsulfanyl)propan-2-ol
carsatrin [inn]
2e3s34l69i ,
unii-2e3s34l69i
1-piperazineethanol, 4-(bis(4-fluorophenyl)methyl)-alpha-((1h-purin-6-ylthio)methyl)-
1-piperazineethanol, 4-(bis(4-fluorophenyl)methyl)-.alpha.-((9h-purin-6-ylthio)methyl)-, (+/-)-
(+/-)-4-(bis(p-fluorophenyl)methyl)-.alpha.-((9h-purin-6-ylthio)methyl)-1-piperazineethanol
SCHEMBL1229997
DTXSID90869724
Q27254614

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (10)

Assay IDTitleYearJournalArticle
AID217787Effective concentration against Xenopus oocytes expressing human heart Na channel1995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
Synthesis and structure-activity relationships of 6-heterocyclic-substituted purines as inactivation modifiers of cardiac sodium channels.
AID72698Relative change in CF was determined by calculating the effective concentration that produced a 50% of maximum increase in tension1992Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24
Synthesis and SAR of 6-substituted purine derivatives as novel selective positive inotropes.
AID56098Cardiac force in dog after administering ca. 1.875 mg/Kg drug intravenously.1992Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24
Synthesis and SAR of 6-substituted purine derivatives as novel selective positive inotropes.
AID217786Inactivation processes of human heart Na channel expressed in Xenopus oocytes as increase in current at 10 uM1995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
Synthesis and structure-activity relationships of 6-heterocyclic-substituted purines as inactivation modifiers of cardiac sodium channels.
AID61747dP/dt max was determined in dog1992Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24
Synthesis and SAR of 6-substituted purine derivatives as novel selective positive inotropes.
AID59028Mean arterial blood pressure in dog after administering ca. 1.875 mg/Kg drug intravenously.1992Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24
Synthesis and SAR of 6-substituted purine derivatives as novel selective positive inotropes.
AID72701In vitro changes in contractile force (CF) quantitated by determining the maximal increase in isometric tension by using ferret papillary muscle1992Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24
Synthesis and SAR of 6-substituted purine derivatives as novel selective positive inotropes.
AID217784Inactivation of guinea pig cardiac Na channel expressed in Xenopus oocytes as increased current at 10 uM; not determined1995Journal of medicinal chemistry, Jul-07, Volume: 38, Issue:14
Synthesis and structure-activity relationships of 6-heterocyclic-substituted purines as inactivation modifiers of cardiac sodium channels.
AID59160Heart rate in dog after administering ca. 1.875 mg/Kg drug intravenously1992Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24
Synthesis and SAR of 6-substituted purine derivatives as novel selective positive inotropes.
AID59814Effective dose required to produce 50% increase of cardiac force in dog after administering ca. 1.875 mg/Kg drug intravenously1992Journal of medicinal chemistry, Nov-27, Volume: 35, Issue:24
Synthesis and SAR of 6-substituted purine derivatives as novel selective positive inotropes.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's5 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
verapamil
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.		1.9810aromatic ether;
nitrile;
polyether;
tertiary amino compound
flecainide
Flecainide: A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial ARRHYTHMIAS and TACHYCARDIAS.. flecainide : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 2,5-bis(2,2,2-trifluoroethoxy)benzoic acid with the primary amino group of piperidin-2-ylmethylamine. An antiarrhythmic agent used (in the form of its acetate salt) to prevent and treat tachyarrhythmia (abnormal fast rhythm of the heart).		1.9810aromatic ether;
monocarboxylic acid amide;
organofluorine compound;
piperidines		anti-arrhythmia drug
lidocaine
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.. lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.		1.9810benzenes;
monocarboxylic acid amide;
tertiary amino compound		anti-arrhythmia drug;
drug allergen;
environmental contaminant;
local anaesthetic;
xenobiotic
dpi 201-106
DPI 201-106: structure given in first source		2.6730diarylmethane
tetraethylammonium
Tetraethylammonium: A potassium-selective ion channel blocker. (From J Gen Phys 1994;104(1):173-90)		1.9810quaternary ammonium ion
bdf 9148
BDF 9148: sodium channel activator; structure given in first source; BDF 9196 - S enantiomer; LY-341311 is the (S)-isomer and monohydrate		1.9810
quinidine
Quinidine: An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.. quinidine : A cinchona alkaloid consisting of cinchonine with the hydrogen at the 6-position of the quinoline ring substituted by methoxy.		1.9810cinchona alkaloidalpha-adrenergic antagonist;
anti-arrhythmia drug;
antimalarial;
drug allergen;
EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor;
EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor;
muscarinic antagonist;
P450 inhibitor;
potassium channel blocker;
sodium channel blocker
mercaptopurine
Mercaptopurine: An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.. purine-6-thiol : A thiol that is the tautomer of mercaptopurine.. mercaptopurine : A member of the class of purines that is 6,7-dihydro-1H-purine carrying a thione group at position 6. An adenine analogue, it is used in the treatment of acute lymphocytic leukemia (ALL), chronic myeloid leukemia (CML), Crohn's disease, and ulcerative colitis.		2.940aryl thiol;
purines;
thiocarbonyl compound		anticoronaviral agent;
antimetabolite;
antineoplastic agent
tetrodotoxin
Tetrodotoxin: An aminoperhydroquinazoline poison found mainly in the liver and ovaries of fishes in the order TETRAODONTIFORMES, which are eaten. The toxin causes paresthesia and paralysis through interference with neuromuscular conduction.. tetrodotoxin : A quinazoline alkaloid that is a marine toxin isolated from fish such as puffer fish. It has been shown to exhibit potential neutotoxicity due to its ability to block voltage-gated sodium channels.		1.9810azatetracycloalkane;
oxatetracycloalkane;
quinazoline alkaloid		animal metabolite;
bacterial metabolite;
marine metabolite;
neurotoxin;
voltage-gated sodium channel blocker
ConditionIndicatedRelationship StrengthStudiesTrials
Muscle Contraction
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.		0210