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bisorbicillinol

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Description

bisorbicillinol: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11375385
CHEMBL ID518705
MeSH IDM0448974

Synonyms (3)

Synonym
bisorbicillinol
CHEMBL518705
(1r,2s,6s,7s,8s,9s,12z)-2-[(2e,4e)-hexa-2,4-dienoyl]-5,6,9-trihydroxy-12-[(2e,4e)-1-hydroxyhexa-2,4-dienylidene]-1,4,6,9-tetramethyltricyclo[6.2.2.02,7]dodec-4-ene-3,10,11-trione
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (22)

Assay IDTitleYearJournalArticle
AID402287Antimicrobial activity against Scenedesmus subspicatus at 20 ug/9 mm disk by agar diffusion method2005Journal of natural products, Jun, Volume: 68, Issue:6
Sorbicillin analogues and related dimeric compounds from Penicillium notatum.
AID402283Antimicrobial activity against Candida albicans at 20 ug/9 mm disk by agar diffusion method2005Journal of natural products, Jun, Volume: 68, Issue:6
Sorbicillin analogues and related dimeric compounds from Penicillium notatum.
AID1624699Anti-allergic activity in rat RBL2H3 cells assessed as reduction in mouse anti-DNP IgE-induced TNF-alpha level preincubated for 15 mins followed by mouse anti-DNP IgE-stimulation and measured after 3 hrs by ELISA2019Bioorganic & medicinal chemistry letters, 03-15, Volume: 29, Issue:6
Bisorbicillinol inhibits Lyn tyrosine kinase for allergic response on RBL-2H3 cells.
AID1624702Anti-allergic activity in rat RBL2H3 cells assessed as reduction in calcium ionophore-induced TNF-alpha level preincubated for 15 mins followed by calcium ionophore stimulation and measured after 3 hrs by ELISA2019Bioorganic & medicinal chemistry letters, 03-15, Volume: 29, Issue:6
Bisorbicillinol inhibits Lyn tyrosine kinase for allergic response on RBL-2H3 cells.
AID1624708Effect on mouse anti-DNP IgE-induced Syk protein expression in rat RBL2H3 cells at 10 uM preincubated for 15 mins followed by mouse anti-DNP IgE stimulation and measured after 3 hrs by Western blot analysis2019Bioorganic & medicinal chemistry letters, 03-15, Volume: 29, Issue:6
Bisorbicillinol inhibits Lyn tyrosine kinase for allergic response on RBL-2H3 cells.
AID1624709Competitive inhibition of human LYN expressed in baculovirus infected Sf9 insect cells using p-nitrophenol at 10 uM after 10 mins by Lineweaver-Burk plot analysis2019Bioorganic & medicinal chemistry letters, 03-15, Volume: 29, Issue:6
Bisorbicillinol inhibits Lyn tyrosine kinase for allergic response on RBL-2H3 cells.
AID1624705Inhibition of Lyn in rat RBL2H3 cells assessed as reduction in mouse anti-DNP IgE-induced PLCgamma1-phosphorylation level at 10 uM preincubated for 15 mins followed by mouse anti-DNP IgE stimulation and measured after 3 hrs by Western blot analysis2019Bioorganic & medicinal chemistry letters, 03-15, Volume: 29, Issue:6
Bisorbicillinol inhibits Lyn tyrosine kinase for allergic response on RBL-2H3 cells.
AID402280Antimicrobial activity against Staphylococcus aureus at 20 ug/9 mm disk by agar diffusion method2005Journal of natural products, Jun, Volume: 68, Issue:6
Sorbicillin analogues and related dimeric compounds from Penicillium notatum.
AID1624700Anti-allergic activity in rat RBL2H3 cells assessed as reduction in mouse anti-DNP IgE-induced IL-4 level preincubated for 15 mins followed by mouse anti-DNP IgE-stimulation and measured after 3 hrs by ELISA2019Bioorganic & medicinal chemistry letters, 03-15, Volume: 29, Issue:6
Bisorbicillinol inhibits Lyn tyrosine kinase for allergic response on RBL-2H3 cells.
AID1624703Anti-allergic activity in rat RBL2H3 cells assessed as reduction in calcium ionophore-induced IL-4 level preincubated for 15 mins followed by calcium ionophore stimulation and measured after 3 hrs by ELISA2019Bioorganic & medicinal chemistry letters, 03-15, Volume: 29, Issue:6
Bisorbicillinol inhibits Lyn tyrosine kinase for allergic response on RBL-2H3 cells.
AID402284Antimicrobial activity against Mucor miehei at 20 ug/9 mm disk by agar diffusion method2005Journal of natural products, Jun, Volume: 68, Issue:6
Sorbicillin analogues and related dimeric compounds from Penicillium notatum.
AID1624698Anti-allergic activity in rat RBL2H3 cells assessed as reduction in mouse anti-DNP IgE-induced beta-hexosaminidase release preincubated for 15 mins followed by mouse anti-DNP IgE-stimulation and measured after 3 hrs by p-nitrophenyl-2-acetamide-2-deoxy-be2019Bioorganic & medicinal chemistry letters, 03-15, Volume: 29, Issue:6
Bisorbicillinol inhibits Lyn tyrosine kinase for allergic response on RBL-2H3 cells.
AID402286Antimicrobial activity against Chlorella sorokiniana at 20 ug/9 mm disk by agar diffusion method2005Journal of natural products, Jun, Volume: 68, Issue:6
Sorbicillin analogues and related dimeric compounds from Penicillium notatum.
AID402285Antimicrobial activity against Chlorella vulgaris at 20 ug/9 mm disk by agar diffusion method2005Journal of natural products, Jun, Volume: 68, Issue:6
Sorbicillin analogues and related dimeric compounds from Penicillium notatum.
AID1624707Effect on mouse anti-DNP IgE-induced Lyn protein expression in rat RBL2H3 cells at 10 uM preincubated for 15 mins followed by mouse anti-DNP IgE stimulation and measured after 3 hrs by Western blot analysis2019Bioorganic & medicinal chemistry letters, 03-15, Volume: 29, Issue:6
Bisorbicillinol inhibits Lyn tyrosine kinase for allergic response on RBL-2H3 cells.
AID1624706Inhibition of mouse anti-DNP IgE-induced Lyn phosphorylation in rat RBL2H3 cells at 10 uM preincubated for 15 mins followed by mouse anti-DNP IgE stimulation and measured after 3 hrs by Western blot analysis2019Bioorganic & medicinal chemistry letters, 03-15, Volume: 29, Issue:6
Bisorbicillinol inhibits Lyn tyrosine kinase for allergic response on RBL-2H3 cells.
AID402282Antimicrobial activity against Escherichia coli at 20 ug/9 mm disk by agar diffusion method2005Journal of natural products, Jun, Volume: 68, Issue:6
Sorbicillin analogues and related dimeric compounds from Penicillium notatum.
AID1624704Inhibition of Lyn in rat RBL2H3 cells assessed as reduction in mouse anti-DNP IgE-induced Syk phosphorylation level at 10 uM preincubated for 15 mins followed by mouse anti-DNP IgE stimulation and measured after 3 hrs by Western blot analysis2019Bioorganic & medicinal chemistry letters, 03-15, Volume: 29, Issue:6
Bisorbicillinol inhibits Lyn tyrosine kinase for allergic response on RBL-2H3 cells.
AID1624710Cytotoxicity in rat RBL2H3 cells assessed as LDH release2019Bioorganic & medicinal chemistry letters, 03-15, Volume: 29, Issue:6
Bisorbicillinol inhibits Lyn tyrosine kinase for allergic response on RBL-2H3 cells.
AID402281Antimicrobial activity against Streptomyces viridochromogenes Tu57 at 20 ug/9 mm disk by agar diffusion method2005Journal of natural products, Jun, Volume: 68, Issue:6
Sorbicillin analogues and related dimeric compounds from Penicillium notatum.
AID402044Antimicrobial activity against Bacillus subtilis at 20 ug/9 mm disk by agar diffusion method2005Journal of natural products, Jun, Volume: 68, Issue:6
Sorbicillin analogues and related dimeric compounds from Penicillium notatum.
AID1624701Anti-allergic activity in rat RBL2H3 cells assessed as reduction in calcium ionophore-induced beta-hexosaminidase release preincubated for 15 mins followed by calcium ionophore-stimulation and measured after 3 hrs by p-nitrophenyl-2-acetamide-2-deoxy-beta2019Bioorganic & medicinal chemistry letters, 03-15, Volume: 29, Issue:6
Bisorbicillinol inhibits Lyn tyrosine kinase for allergic response on RBL-2H3 cells.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (66.67)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]