Compounds > biflorin
Page last updated: 2024-12-08

biflorin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

biflorin: isolated from Capraria biflora; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Caprariagenus[no description available]ScrophulariaceaeThe figwort plant family of the order Lamiales. The family is characterized by bisexual flowers with tubular corollas (fused petals) that are bilaterally symmetrical (two-lips) and have four stamens in most, two of which are usually shorter.[MeSH]

Cross-References

ID SourceID
PubMed CID441959
CHEMBL ID463312
CHEBI ID3094
MeSH IDM0513487

Synonyms (17)

Synonym
biflorin
C08996
89701-85-9
chebi:3094 ,
CHEMBL463312
5,7-dihydroxy-2-methyl-6-[(2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one
DTXSID00331689
5,7-dihydroxy-2-methyl-6-[(2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-4h-chromen-4-one
alpha-glucosidase inhibitor cb-2
6beta-c-glucopyranosyl-5,7-dihydroxy-2-methylchromone
Q27105940
rosa i banuelos
5,7-dihydroxy-2-methyl-6-((2s,3r,4r,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-2-yl)-4h-chromen-4-one
AKOS040750799
4h-1-benzopyran-4-one, 6-beta-d-glucopyranosyl-5,7-dihydroxy-2-methyl-
6-beta-d-glucopyranosyl-5,7-dihydroxy-2-methyl-4h-1-benzopyran-4-one
YJ3TYM754D

Research Excerpts

Overview

Biflorin is an o-naphthoquinone with proven cytotoxic effects on tumor cells showing antimicrobial, antitumor and antimutagenic activities. Biflor in 1 is a biologically active quinone, isolated from Capraria biflora.

ExcerptReferenceRelevance
"Biflorin is an o-naphthoquinone with proven cytotoxic effects on tumor cells showing antimicrobial, antitumor and antimutagenic activities. "( Biflorin: an o-naphthoquinone of clinical significance.
Fonseca, AM; Henriques, JA; Lemos, TL; Moraes, MO; Moura, S; Pessoa, C; Roesch-Ely, M; Simões, ER; Souza, LG; Wisintainer, GG, 2014)		3.29
"Biflorin 1 is a biologically active quinone, isolated from Capraria biflora. "( Synthesis, antibacterial and cytotoxic activities of new biflorin-based hydrazones and oximes.
Almeida, MCS; Barreto, FS; Braz-Filho, R; Costa, JGM; da S Souza, LG; de Brito, ES; de Moraes, MO; Lemos, TLG; Ribeiro, PRV; Rodrigues, FFG; Silva, AMS; Silva, VLM, 2016)		2.12
"Biflorin is a natural quinone isolated from Capraria biflora L. "( Evaluation of the cytotoxic and antimutagenic effects of biflorin, an antitumor 1,4 o-naphthoquinone isolated from Capraria biflora L.
Costa-Lotufo, LV; Fonseca, AM; Guecheva, TN; Henriques, JA; Immich, BF; Lemos, TL; Machado, MS; Montenegro, RC; Moraes, ME; Moraes, MO; Moura, DJ; Rosa, RM; Saffi, J; Vasconcellos, MC; Villela, I, 2010)		2.05

Actions

ExcerptReferenceRelevance
"Biflorin did not inhibit the adhesion of MDA-MB-435 cells to any tested substrates."( A novel o-naphtoquinone inhibits N-cadherin expression and blocks melanoma cell invasion via AKT signaling.
Barbosa, Gdos S; Burbano, RM; Costa-Lotufo, LV; de Moraes, MO; de Vasconcellos, MC; Lemos, TL; Montenegro, RC; Souza, LG, 2013)		1.11

Treatment

ExcerptReferenceRelevance
"Treatment with biflorin (25 and 50mg/kg/day) was shown to be effective in reducing B16-F10 melanoma metastasis in C57BL/6 mice. "( Inhibition of metastatic potential of B16-F10 melanoma cell line in vivo and in vitro by biflorin.
Alves, AP; Andrade Carvalho, A; da Costa, PM; Da Silva Souza, LG; de Moraes, MO; Lemos, TL; Pessoa, C, 2013)		0.96

Pharmacokinetics

ExcerptReferenceRelevance
" This method was successfully applied to a pharmacokinetic study of biflorin after the intravenous and oral administration of biflorin to rats."( A sensitive LC-MS/MS method for the quantitative determination of biflorin in rat plasma and its application to pharmacokinetic studies.
Han, HK; Jang, DS; Ryu, JH; Yang, L; Yang, SJ, 2015)		0.89
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
chromonesA chromenone that consists of a 1,4-benzopyrone skeleton and its substituted derivatives thereof.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (50)

Assay IDTitleYearJournalArticle
AID1634905Antiinflammatory activity in mouse RAW264.7 cell lysate assessed as inhibition of LPS-induced COX-2 expression preincubated for 1 hr followed by LPS challenge for 24 hrs by Western blot analysis2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634899Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 1 hr followed by LPS challenge for 24 hrs by Griess assay2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634917Inhibition of LPS-induced STAT1 phosphorylation at S727 in mouse RAW264.7 cells at 15 to 60 uM preincubated for 1 hr followed by LPS challenge for 15 mins by Western blot analysis2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634915Inhibition of LPS-induced AP-1 activity in mouse RAW264.7 cells at 15 to 60 uM preincubated for 1 hr followed by LPS challenge for 12 hrs by luciferase reporter gene assay2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634906Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced iNOS mRNA expression at 60 uM after 2 to 12 hrs by qRT-PCR method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634924Inhibition of LPS-induced JNK phosphorylation in mouse RAW264.7 cells at 15 to 60 uM preincubated for 1 hr followed by LPS challenge for 30 mins by Western blot analysis2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634902Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 60 uM after 24 hrs by MTT assay in absence of LPS2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634923Inhibition of LPS-induced ERK1/2 phosphorylation in mouse RAW264.7 cells at 15 to 60 uM preincubated for 1 hr followed by LPS challenge for 30 mins by Western blot analysis2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634896Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha production at 60 uM preincubated for 1 hr followed by LPS challenge for 24 hrs by ELISA method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634903Cytotoxicity against mouse RAW264.7 cells assessed as cell viability at 60 uM after 24 hrs by MTT assay in presence of LPS2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634919Inhibition of LPS-induced STAT1 phosphorylation at Y701 in C57BL/6 mouse peritoneal macrophages at 15 to 60 uM preincubated for 1 hr followed by LPS challenge for 120 mins by Western blot analysis2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID355137Antimicrobial activity against Streptococcus mutans Ingbritt by disk diffusion method1996Journal of natural products, Oct, Volume: 59, Issue:10
Compounds from Syzygium aromaticum possessing growth inhibitory activity against oral pathogens.
AID1634920Inhibition of LPS-induced STAT1 phosphorylation at S727 in C57BL/6 mouse peritoneal macrophages at 15 to 60 uM preincubated for 1 hr followed by LPS challenge for 30 mins by Western blot analysis2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634921Inhibition of LPS-induced STAT3 phosphorylation at Y705 in C57BL/6 mouse peritoneal macrophages at 15 to 60 uM preincubated for 1 hr followed by LPS challenge for 60 mins by Western blot analysis2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634940Antiinflammatory activity in Sprague-Dawley rat assessed as inhibition of croton oil-induced inflammatory cell infiltration at 10 mg/kg, ip administered 1 hr before croton oil challenge measured after 3 hrs by hematoxylin and eosin staining based assay2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634894Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced TNF-alpha mRNA expression at 60 uM after 2 to 12 hrs by qRT-PCR method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634930Protection against LPS-induced mortality in C57BL/6 mouse assessed as lethality level at 5 to 10 mg/kg, ip pretreated for 1 hr followed by LPS challenge measured every 12 hrs for 96 hrs post challenge2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634927Inhibition of LPS-induced TNF-alpha mRNA expression in C57BL/6 mouse liver at 10 mg/kg, ip pretreated for 1 hr followed by LPS challenge for 6 hrs by qRT-PCR method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634936Antiinflammatory activity in Sprague-Dawley rat assessed as inhibition of croton oil-induced ear edema at 10 mg/kg, ip administered 1 hr before croton oil challenge measured after 3 hrs post challenge relative to control2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634913Cytotoxicity against C57BL/6 mouse peritoneal macrophages assessed as cell viability at 60 uM after 24 hrs by MTT assay2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634908Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced iNOS promoter activity at 60 uM preincubated for 1 hr followed by LPS challenge for 6 to 12 hrs by reporter gene assay2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634911Antiinflammatory activity in C57BL/6 mouse peritoneal macrophages assessed as inhibition of LPS-induced TNF-alpha production at 60 uM preincubated for 1 hr followed by LPS challenge for 48 hrs by ELISA method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634898Antiinflammatory activity in C57BL/6 mouse peritoneal macrophages assessed as inhibition of LPS-induced nitric oxide production at 60 uM preincubated for 1 hr followed by LPS challenge for 48 hrs by Griess assay2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634901Cytotoxicity against mouse RAW264.7 cells assessed as decrease in cell viability after 24 hrs by MTT assay2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634928Invivo inhibition of LPS-induced STAT1 phosphorylation at Y701 in C57BL/6 mouse liver at 10 mg/kg, ip pretreated for 1 hr followed by LPS challenge for 6 hrs by Western blot analysis2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634929Invivo inhibition of LPS-induced STAT1 phosphorylation at S727 in C57BL/6 mouse liver at 10 mg/kg, ip pretreated for 1 hr followed by LPS challenge for 6 hrs by Western blot analysis2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634926Inhibition of LPS-induced COX-2 mRNA expression in C57BL/6 mouse liver at 10 mg/kg, ip pretreated for 1 hr followed by LPS challenge for 6 hrs by qRT-PCR method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634932Antiinflammatory activity in Sprague-Dawley rat assessed as reduction in carrageenan induced paw edema at 10 mg/kg, ip administered 1 hr before carrageenan challenge measured at 3 hrs post challenge relative to control2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634910Antiinflammatory activity in C57BL/6 mouse peritoneal macrophages assessed as inhibition of LPS-induced PGE2 production at 60 uM preincubated for 1 hr followed by LPS challenge for 48 hrs by ELISA method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634907Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced COX-2 mRNA expression at 60 uM after 2 to 12 hrs by qRT-PCR method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634925Inhibition of LPS-induced iNOS mRNA expression in C57BL/6 mouse liver at 10 mg/kg, ip pretreated for 1 hr followed by LPS challenge for 6 hrs by qRT-PCR method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634895Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-6 production at 60 uM preincubated for 1 hr followed by LPS challenge for 24 hrs by ELISA method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634904Antiinflammatory activity in mouse RAW264.7 cell lysate assessed as inhibition of LPS-induced iNOS expression preincubated for 1 hr followed by LPS challenge for 24 hrs by Western blot analysis2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID355136Antimicrobial activity against Prevotella intermedia by disk diffusion method1996Journal of natural products, Oct, Volume: 59, Issue:10
Compounds from Syzygium aromaticum possessing growth inhibitory activity against oral pathogens.
AID1634893Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-6 mRNA expression at 60 uM after 2 to 12 hrs by qRT-PCR method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634912Antiinflammatory activity in C57BL/6 mouse peritoneal macrophages assessed as inhibition of LPS-induced IL-6 production at 60 uM preincubated for 1 hr followed by LPS challenge for 48 hrs by ELISA method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634909Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced COX-2 promoter activity at 60 uM preincubated for 1 hr followed by LPS challenge for 6 to 12 hrs by reporter gene assay2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634922Inhibition of LPS-induced p38 MAPK phosphorylation in mouse RAW264.7 cells preincubated for 1 hr followed by LPS challenge for 30 mins by Western blot analysis2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634914Reduction in LPS-induced NF-kappa B activity in mouse RAW264.7 cells at 15 to 60 uM preincubated for 1 hr followed by LPS challenge for 12 hrs by luciferase reporter gene assay2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID355138Antimicrobial activity against Actinomyces viscosus W1053 by disk diffusion method1996Journal of natural products, Oct, Volume: 59, Issue:10
Compounds from Syzygium aromaticum possessing growth inhibitory activity against oral pathogens.
AID1634918Inhibition of LPS-induced STAT3 phosphorylation at Y705 in mouse RAW264.7 cells at 15 to 60 uM preincubated for 1 hr followed by LPS challenge for 120 mins by Western blot analysis2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634933Antiinflammatory activity in Sprague-Dawley rat assessed as reduction in carrageenan induced paw edema at 15 mg/kg, ip administered 1 hr before carrageenan challenge measured at 3 hrs post challenge relative to control2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID355135Antimicrobial activity against Porphyromonas gingivalis ATCC 33277 by disk diffusion method1996Journal of natural products, Oct, Volume: 59, Issue:10
Compounds from Syzygium aromaticum possessing growth inhibitory activity against oral pathogens.
AID1634937Antiinflammatory activity in Sprague-Dawley rat assessed as inhibition of croton oil-induced ear edema at 15 mg/kg, ip administered 1 hr before croton oil challenge measured after 3 hrs post challenge relative to control2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634900Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced PGE2 production preincubated for 1 hr followed by LPS challenge for 24 hrs by ELISA method2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634939Antiinflammatory activity in Sprague-Dawley rat assessed as inhibition of croton oil-induced ear edema at 10 mg/kg, ip administered 1 hr before croton oil challenge measured after 3 hrs by hematoxylin and eosin staining based assay2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634931Antiinflammatory activity in Sprague-Dawley rat assessed as reduction in carrageenan induced paw edema at 5 mg/kg, ip administered 1 hr before carrageenan challenge measured at 3 hrs post challenge relative to control2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634897Antiinflammatory activity in mouse RAW264.7 cells assessed as downregulation of LPS-induced TNF-alpha expression at 60 uM preincubated for 1 hr followed by LPS challenge for 6 to 12 hrs by luciferase reporter gene assay2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634935Antiinflammatory activity in Sprague-Dawley rat assessed as inhibition of croton oil-induced ear edema at 5 mg/kg, ip administered 1 hr before croton oil challenge measured after 3 hrs post challenge relative to control2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
AID1634916Inhibition of LPS-induced STAT1 phosphorylation at Y701 in mouse RAW264.7 cells at 15 to 60 uM preincubated for 1 hr followed by LPS challenge for 120 mins by Western blot analysis2016Journal of natural products, Apr-22, Volume: 79, Issue:4
Biflorin, Isolated from the Flower Buds of Syzygium aromaticum L., Suppresses LPS-Induced Inflammatory Mediators via STAT1 Inactivation in Macrophages and Protects Mice from Endotoxin Shock.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (13)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (7.69)18.2507
2000's1 (7.69)29.6817
2010's10 (76.92)24.3611
2020's1 (7.69)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 29.09

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index29.09 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index5.29 (4.65)
Search Engine Demand Index65.76 (26.88)
Search Engine Supply Index4.00 (0.95)

This Compound (29.09)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other13 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
gallic acid
gallate : A trihydroxybenzoate that is the conjugate base of gallic acid.		1.9910trihydroxybenzoic acidantineoplastic agent;
antioxidant;
apoptosis inducer;
astringent;
cyclooxygenase 2 inhibitor;
EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor;
geroprotector;
human xenobiotic metabolite;
plant metabolite
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		2.0310nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
ibuprofen
Midol: combination of cinnamedrine, phenacetin, aspirin & caffeine		2.1310monocarboxylic acidantipyretic;
cyclooxygenase 1 inhibitor;
cyclooxygenase 2 inhibitor;
drug allergen;
environmental contaminant;
geroprotector;
non-narcotic analgesic;
non-steroidal anti-inflammatory drug;
radical scavenger;
xenobiotic
sanguinarine
benzophenanthridine alkaloid : A specific group of isoquinoline alkaloids that occur only in higher plants and are constituents mainly of the Papaveraceae family.		1.9910alkaloid antibiotic;
benzophenanthridine alkaloid;
botanical anti-fungal agent
oleanolic acid
[no description available]		1.9910hydroxy monocarboxylic acid;
pentacyclic triterpenoid		plant metabolite
ovalbumin
Ovalbumin: An albumin obtained from the white of eggs. It is a member of the serpin superfamily.		2.0310
naphthoquinones
Naphthoquinones: Naphthalene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.		3.97120
dinoprostone
prostaglandin E2 : Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.		2.1310prostaglandins Ehuman metabolite;
mouse metabolite;
oxytocic
kaempferol
[no description available]		1.99107-hydroxyflavonol;
flavonols;
tetrahydroxyflavone		antibacterial agent;
geroprotector;
human blood serum metabolite;
human urinary metabolite;
human xenobiotic metabolite;
plant metabolite
myricetin
[no description available]		1.99107-hydroxyflavonol;
hexahydroxyflavone		antineoplastic agent;
antioxidant;
cyclooxygenase 1 inhibitor;
food component;
geroprotector;
hypoglycemic agent;
plant metabolite
ellagic acid
[no description available]		1.9910catechols;
cyclic ketone;
lactone;
organic heterotetracyclic compound;
polyphenol		antioxidant;
EC 1.14.18.1 (tyrosinase) inhibitor;
EC 2.3.1.5 (arylamine N-acetyltransferase) inhibitor;
EC 2.4.1.1 (glycogen phosphorylase) inhibitor;
EC 2.5.1.18 (glutathione transferase) inhibitor;
EC 2.7.1.127 (inositol-trisphosphate 3-kinase) inhibitor;
EC 2.7.1.151 (inositol-polyphosphate multikinase) inhibitor;
EC 2.7.4.6 (nucleoside-diphosphate kinase) inhibitor;
EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor;
EC 5.99.1.2 (DNA topoisomerase) inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
food additive;
fungal metabolite;
geroprotector;
plant metabolite;
skin lightening agent
kaempferol-7-methyl ether
rhamnocitrin : A monomethoxyflavone that is the 7-methyl ether derivative of kaempferol.		1.9910flavonols;
monomethoxyflavone;
trihydroxyflavone		plant metabolite
ConditionIndicatedRelationship StrengthStudiesTrials
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.1310
Anasarca
[description not available]		02.1310
Edema
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.		02.1310
Endotoxemia
A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.		02.1310
Cancer of Stomach
[description not available]		02.2510
Stomach Neoplasms
Tumors or cancer of the STOMACH.		02.2510
Cancer of Lung
[description not available]		02.0810
B16 Melanoma
[description not available]		02.4820
Invasiveness, Neoplasm
[description not available]		02.0810
Lung Neoplasms
Tumors or cancer of the LUNG.		02.0810
Malignant Melanoma
[description not available]		02.7830
Melanoma
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)		02.7830
Bacterial Disease
[description not available]		02.1310
Benign Neoplasms
[description not available]		02.1310
Bacterial Infections
Infections by bacteria, general or unspecified.		02.1310
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.1310
Cancer of Skin
[description not available]		02.0610
Skin Neoplasms
Tumors or cancer of the SKIN.		02.0610
Carcinoma, Ehrlich Tumor
A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.		02.0310
Sarcoma 180
An experimental sarcoma of mice.		02.0310