Beta-guanidinobutyric acid (β-GBA) is a naturally occurring amino acid found in various organisms, including mammals, plants, and bacteria. It is a derivative of the amino acid gamma-aminobutyric acid (GABA) with a guanidine group attached to the gamma carbon. Research on β-GBA has focused on its potential role in various biological processes, including:
* **Neurotransmission:** β-GBA is thought to be involved in the modulation of GABAergic neurotransmission, acting as a weak GABA receptor agonist.
* **Metabolic pathways:** β-GBA is a precursor for the biosynthesis of creatinine, a waste product that is excreted by the kidneys.
* **Muscle function:** β-GBA may play a role in muscle energy metabolism, contributing to muscle growth and repair.
* **Antioxidant activity:** Studies suggest that β-GBA exhibits antioxidant properties, protecting cells from oxidative damage.
Synthesis of β-GBA is typically achieved through chemical methods involving the reaction of GABA with guanidine. However, research on β-GBA's role in various biological pathways and its potential therapeutic applications is ongoing, particularly in areas like neurodegenerative diseases and muscle disorders.'
beta-guanidinobutyric acid: creatine antagonist [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 97855 |
| CHEMBL ID | 21110 |
| SCHEMBL ID | 5170315 |
| MeSH ID | M0100839 |
| Synonym |
|---|
| nsc49063 |
| 352-83-0 |
| .beta.-gba |
| nsc-49063 |
| 3-guanidinobutyric acid |
| beta-guanidinobutyric acid |
| CHEMBL21110 |
| 3-guanidino-butyric acid |
| 3-(diaminomethylideneamino)butanoic acid |
| butanoic acid, 3-((aminoiminomethyl)amino)- |
| beta-gba |
| nsc 49063 |
| AKOS006338641 |
| SCHEMBL5170315 |
| KKGUWQNQEARROH-UHFFFAOYSA-N |
| 3-([amino(imino)methyl]amino)butanoic acid # |
| .beta.-guanidinobutyric acid |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID94678 | In vivo blood glucose was determined in obese, hyperglycemic, hyperinsulinemic, insulin-resistant KKAy mice after a dose of 500 mg/kg for 4 days | 2001 | Journal of medicinal chemistry, Apr-12, Volume: 44, Issue:8 | Synthesis and biological activity of analogues of the antidiabetic/antiobesity agent 3-guanidinopropionic acid: discovery of a novel aminoguanidinoacetic acid antidiabetic agent. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 3 (37.50) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.11) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||