Compounds > beta-ethyl, beta-methyl-thiobutyrolactone
Page last updated: 2024-11-07

beta-ethyl, beta-methyl-thiobutyrolactone

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID128424
CHEMBL ID286803
MeSH IDM0147540

Synonyms (8)

Synonym
beta-emtbl
CHEMBL286803
4-ethyl-4-methylthiolan-2-one
103620-94-6
beta-ethyl, beta-methyl-thiobutyrolactone
beta-ethyl-beta-methyl-thiobutyrolactone
2(3h)-thiophenone, 4-ethyldihydro-4-methyl-
DTXSID70908529
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Protein Targets (16)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)IC50 (µMol)8,600.00000.00010.507510.0000AID71294
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)IC50 (µMol)8,600.00000.00010.507510.0000AID71294
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)IC50 (µMol)8,600.00000.00010.507510.0000AID71294
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)IC50 (µMol)8,600.00000.00010.505710.0000AID71294
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)IC50 (µMol)8,600.00000.00010.497310.0000AID71294
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)IC50 (µMol)8,600.00000.00010.507510.0000AID71294
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)IC50 (µMol)8,600.00000.00010.498810.0000AID71294
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)IC50 (µMol)8,600.00000.00010.504610.0000AID71294
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)IC50 (µMol)8,600.00000.00010.507510.0000AID71294
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)IC50 (µMol)8,600.00000.00010.507510.0000AID71294
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)IC50 (µMol)8,600.00000.00010.507510.0000AID71294
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)IC50 (µMol)8,600.00000.00010.506510.0000AID71294
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)IC50 (µMol)8,600.00000.00010.505710.0000AID71294
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)IC50 (µMol)8,600.00000.00010.507510.0000AID71294
GABA theta subunitRattus norvegicus (Norway rat)IC50 (µMol)8,600.00000.00010.507510.0000AID71294
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)IC50 (µMol)8,600.00000.00010.507510.0000AID71294
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Ceullar Components (1)

Processvia Protein(s)Taxonomy
plasma membraneGamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)
plasma membraneGamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)
plasma membraneGamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID113590Compound was evaluated for convulsant activity in mice that caused clonic seizures at the 12.5 mg/kg dose; 3/31986Journal of medicinal chemistry, Oct, Volume: 29, Issue:10
Alkyl-substituted thiolo-, thiono-, and dithio-gamma-butyrolactones: new classes of convulsant and anticonvulsant agents.
AID113751Compound was evaluated for convulsant activity in mice that caused tonic seizures at the 15 mg/kg dose; 5/51986Journal of medicinal chemistry, Oct, Volume: 29, Issue:10
Alkyl-substituted thiolo-, thiono-, and dithio-gamma-butyrolactones: new classes of convulsant and anticonvulsant agents.
AID113740Compound was evaluated for convulsant activity in mice that caused clonic seizures at the 6.25 mg/kg dose; 3/31986Journal of medicinal chemistry, Oct, Volume: 29, Issue:10
Alkyl-substituted thiolo-, thiono-, and dithio-gamma-butyrolactones: new classes of convulsant and anticonvulsant agents.
AID110442Convulsant potency was determined by measuring the ability to produce seizures in mice1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
Synthesis and structure-activity studies of alkyl-substituted gamma-butyrolactones and gamma-thiobutyrolactones: ligands for the picrotoxin receptor.
AID113737Compound was evaluated for convulsant activity in mice that caused clonic seizures at the 5.0 mg/kg dose; 3/41986Journal of medicinal chemistry, Oct, Volume: 29, Issue:10
Alkyl-substituted thiolo-, thiono-, and dithio-gamma-butyrolactones: new classes of convulsant and anticonvulsant agents.
AID113735Compound was evaluated for convulsant activity in mice that caused clonic seizures at the 3.1 mg/kg dose; 1/31986Journal of medicinal chemistry, Oct, Volume: 29, Issue:10
Alkyl-substituted thiolo-, thiono-, and dithio-gamma-butyrolactones: new classes of convulsant and anticonvulsant agents.
AID71294Binding affinity to picrotoxin site of Gamma-aminobutyric acid receptor using [35S]TBPS as radioligand1991Journal of medicinal chemistry, Apr, Volume: 34, Issue:4
Synthesis and structure-activity studies of alkyl-substituted gamma-butyrolactones and gamma-thiobutyrolactones: ligands for the picrotoxin receptor.
AID113586Compound was evaluated for convulsant activity in mice that caused clonic seizures at the 10 mg/kg dose; 5/51986Journal of medicinal chemistry, Oct, Volume: 29, Issue:10
Alkyl-substituted thiolo-, thiono-, and dithio-gamma-butyrolactones: new classes of convulsant and anticonvulsant agents.
AID113756Compound was evaluated for convulsant activity in mice that caused tonic seizures at the 5.0 mg/kg dose; 0/41986Journal of medicinal chemistry, Oct, Volume: 29, Issue:10
Alkyl-substituted thiolo-, thiono-, and dithio-gamma-butyrolactones: new classes of convulsant and anticonvulsant agents.
AID113750Compound was evaluated for convulsant activity in mice that caused tonic seizures at the 12.5 mg/kg dose; 3/31986Journal of medicinal chemistry, Oct, Volume: 29, Issue:10
Alkyl-substituted thiolo-, thiono-, and dithio-gamma-butyrolactones: new classes of convulsant and anticonvulsant agents.
AID113746Compound was evaluated for convulsant activity in mice that caused tonic seizures at the 10 mg/kg dose; 5/51986Journal of medicinal chemistry, Oct, Volume: 29, Issue:10
Alkyl-substituted thiolo-, thiono-, and dithio-gamma-butyrolactones: new classes of convulsant and anticonvulsant agents.
AID113760Compound was evaluated for convulsant activity in mice that caused tonic seizures at the 6.25 mg/kg dose; 1/31986Journal of medicinal chemistry, Oct, Volume: 29, Issue:10
Alkyl-substituted thiolo-, thiono-, and dithio-gamma-butyrolactones: new classes of convulsant and anticonvulsant agents.
AID113591Compound was evaluated for convulsant activity in mice that caused clonic seizures at the 15 mg/kg dose; 5/51986Journal of medicinal chemistry, Oct, Volume: 29, Issue:10
Alkyl-substituted thiolo-, thiono-, and dithio-gamma-butyrolactones: new classes of convulsant and anticonvulsant agents.
AID113754Compound was evaluated for convulsant activity in mice that caused tonic seizures at the 3.1 mg/kg dose; 0/31986Journal of medicinal chemistry, Oct, Volume: 29, Issue:10
Alkyl-substituted thiolo-, thiono-, and dithio-gamma-butyrolactones: new classes of convulsant and anticonvulsant agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (40.00)18.7374
1990's3 (60.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.59

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.59 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.54 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.59)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
gamma-aminobutyric acid
gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.. gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4.		2.3720amino acid zwitterion;
gamma-amino acid;
monocarboxylic acid		human metabolite;
neurotransmitter;
Saccharomyces cerevisiae metabolite;
signalling molecule
chlorine
chloride : A halide anion formed when chlorine picks up an electron to form an an anion.		1.9710halide anion;
monoatomic chlorine		cofactor;
Escherichia coli metabolite;
human metabolite
ethosuximide
Ethosuximide: An anticonvulsant especially useful in the treatment of absence seizures unaccompanied by other types of seizures.. ethosuximide : A dicarboximide that is pyrrolidine-2,5-dione in which the hydrogens at position 3 are substituted by one methyl and one ethyl group. An antiepileptic, it is used in the treatment of absence seizures and may be used for myoclonic seizures, but is ineffective against tonic-clonic seizures.		1.9910dicarboximide;
pyrrolidinone		anticonvulsant;
geroprotector;
T-type calcium channel blocker
pentobarbital
Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236). pentobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and sec-pentyl groups.		1.9710barbituratesGABAA receptor agonist
4-butyrolactone
4-Butyrolactone: One of the FURANS with a carbonyl thereby forming a cyclic lactone. It is an endogenous compound made from gamma-aminobutyrate and is the precursor of gamma-hydroxybutyrate. It is also used as a pharmacological agent and solvent.. tetrahydrofuranone : Any oxolane having an oxo- substituent at any position on the tetrahydrofuran ring.. gamma-butyrolactone : A butan-4-olide that is tetrahydrofuran substituted by an oxo group at position 2.		2.6730butan-4-olidemetabolite;
neurotoxin
alpha-ethyl, alpha-methyl-thiobutyrolactone
[no description available]		3.0750tetrahydrothiophenes
alpha-isopropyl-alpha-methyl-gamma-butyrolactone
alpha-isopropyl-alpha-methyl-gamma-butyrolactone: structure given in first source; picrotoxin receptor antagonist		1.9710
2-ethyl-2-methyl-4-butyrolactone
2-ethyl-2-methyl-4-butyrolactone: structure given in first source		2.6730gamma-lactone
picrotoxinin
picrotoxinin: toxic component of PICROTOXIN; structure; noncompetitive antagonist of ionotropic GABA-A receptors. picrotoxinin : A picrotoxane sesquiterpenoid that is 3a,4,5,6,7,7a-hexahydro-1H-indene-3,7-dicarboxylic acid which is substituted at positions 3a, 6, and 7a by methyl, isopropenyl, and hydroxy groups, respectively; in which the double bond at position 2-3 has been epoxidised; and in which the carboxy groups at positions 3 and 7 have undergone gamma-lactone formation by O-alkylation to positions 4 and 5, respectively. A component of picrotoxin.		1.9710
picrotoxin
Picrotoxin: A noncompetitive antagonist at GABA-A receptors and thus a convulsant. Picrotoxin blocks the GAMMA-AMINOBUTYRIC ACID-activated chloride ionophore. Although it is most often used as a research tool, it has been used as a CNS stimulant and an antidote in poisoning by CNS depressants, especially the barbiturates.. picrotoxin : A mixture consisting of equimolar amounts of picrotoxinin and picrotin found in the climbing plant Anamirta cocculus.		2.3720
ConditionIndicatedRelationship StrengthStudiesTrials
Absence Seizure
[description not available]		01.9710
Seizures
Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.		01.9710