Benzoxonium chloride is a quaternary ammonium compound with broad-spectrum antimicrobial activity. It is used as a disinfectant and antiseptic in various applications, including healthcare, consumer products, and industrial settings. The compound is typically synthesized by reacting a benzoxazole derivative with a chlorinating agent. Benzoxonium chloride exhibits bactericidal, fungicidal, and virucidal properties. Its mechanism of action involves disruption of the bacterial cell membrane, leading to cell death. Due to its effectiveness against a wide range of microorganisms, benzoxonium chloride has been studied extensively for its potential in various applications. Research has focused on its efficacy against antibiotic-resistant bacteria, its use in wound care, and its potential as a biocide in industrial settings. The compound is also being investigated for its antiviral properties against enveloped viruses, including influenza and HIV. Its importance lies in its ability to control infections and prevent the spread of microorganisms. However, concerns about its toxicity and potential environmental impact have also been raised, leading to ongoing research on safer alternatives.'
benzoxonium chloride: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 29563 |
| CHEMBL ID | 2104255 |
| SCHEMBL ID | 225516 |
| MeSH ID | M0061957 |
| Synonym |
|---|
| chlorure de benzoxonium [inn-french] |
| d-301 |
| dodecyldi(beta-hydroxyethyl)benzylammonium chloride |
| di(2-hydroxyethyl)benzyldodecylammonium chloride |
| epa pesticide chemical code 069181 |
| ammonium, benzylbis(2-hydroxyethyl)dodecyl-, chloride |
| nsc 141905 |
| ammonium, benzyldodecylbis(2-hydroxyethyl)-, chloride |
| dodecyl di(2-hydroxyethyl) benzyl ammonium chloride |
| katanol c12 |
| einecs 243-008-1 |
| n-dodecyl-n,n-bis(2-hydroxyethyl)benzenemethanaminium chloride |
| cloruro de benzoxonio [inn-spanish] |
| benzoxonii chloridum [inn-latin] |
| benzoxonium chloride |
| orofar |
| benzenemethanaminium, n-dodecyl-n,n-bis(2-hydroxyethyl)-, chloride |
| absonal v |
| caswell no. 416a |
| dodecylbis(beta-hydroxyethyl)benzylammonium chloride |
| bactofen |
| zy 15021 |
| benzoxonium chloride [inn] |
| dodecyl-di(beta-oxyaethyl)-benzyl-ammoniumchlorid [german] |
| bialcol |
| benzoxonium chloride (inn) |
| bialcol (tn) |
| D07069 |
| benzyldodecyldiethanolammonium chloride |
| dodecyldi(2-hydroxyethyl)benzylammonium chloride |
| dodecyl(benzyl)diethanolammonium chloride |
| nsc141905 |
| bis(2-hydroxyethyl)benzyl-n-dodecylammonium chloride |
| benzylbis(2-hydroxyethyl)dodecyl ammonium chloride |
| bis(2-hydroxyethyl)benzyldodecylammonium chloride |
| beloran |
| dodecyl(dioxyethyl)benzylammonium chloride |
| d 301 |
| absonal |
| lomades |
| nsc-141905 |
| laurylbis(2-hydroxyethyl)benzylammonium chloride |
| bradophen |
| benzenemethanaminium,n-bis(2-hydroxyethyl)-, chloride |
| dodecylbis(2-hydroxyethyl)benzylammonium chloride |
| benzyldodecylbis(2-hydroxyethyl)ammonium chloride |
| dodecylbis(.beta.-hydroxyethyl)benzylammonium chloride |
| 19379-90-9 |
| cohortan |
| dodecyldi(.beta.-hydroxyethyl)benzylammonium chloride |
| D301 , |
| 12imo9r11x , |
| dodecyl bis(2-hydroxyethyl) benzyl ammonium chloride |
| unii-12imo9r11x |
| ec 243-008-1 |
| benzenemethanaminium, n-dodecyl-n,n-bis(2-hydroxyethyl)-, chloride (1:1) |
| cloruro de benzoxonio |
| benzoxonii chloridum |
| chlorure de benzoxonium |
| dodecyl-di(beta-oxyaethyl)-benzyl-ammoniumchlorid |
| CHEMBL2104255 |
| zy-15021 |
| SCHEMBL225516 |
| benzoxonium chloride [mart.] |
| benzoxonium chloride [inci] |
| benzoxonium chloride [who-dd] |
| benzoxonium chloride [mi] |
| DTXSID3041906 |
| FT-0736610 |
| Q716544 |
| n-benzyl-n,n-bis(2-hydroxyethyl)dodecan-1-aminium chloride |
| benzyl-dodecyl-bis(2-hydroxyethyl)azanium;chloride |
| 19379-90-9 (chloride) |
| benzoxonium chloride 100 microg/ml in acetonitrile |
| F87833 |
| AKOS040745600 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 9 (60.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.
| This Compound (46.23) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 2 (11.11%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 5 (27.78%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 11 (61.11%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||