Compounds > benzophenothiazine
Page last updated: 2024-12-06

benzophenothiazine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Benzophenothiazine is a heterocyclic compound that has been studied for its potential applications in various fields. It is a tricyclic compound composed of a phenothiazine ring fused to a benzoyl group. Benzophenothiazine exhibits diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties. The compound has shown promising results in inhibiting the growth of cancer cells in vitro and in vivo. Its antioxidant properties are attributed to its ability to scavenge free radicals, which can damage cells and contribute to diseases. The synthesis of benzophenothiazine involves various methods, including the reaction of benzoyl chloride with phenothiazine. Research on benzophenothiazine continues to explore its therapeutic potential and to investigate its mechanism of action in various biological systems.'

Cross-References

ID SourceID
PubMed CID67469
CHEMBL ID390824
SCHEMBL ID26797
MeSH IDM0279809

Synonyms (30)

Synonym
benzo[a]phenothiazine
12h-7-thia-12-azabenz[a]anthracene
nsc88195
225-83-2
nsc-88195
28453-74-9
STL286881
12h-benzo[a]phenothiazine
12h-benzo-[a]phenothiazine
OPREA1_250452
NCIOPEN2_005235
benzophenothiazine
CHEMBL390824
m-627
benzo(a)phenothiazine
einecs 205-931-8
nsc 88195
12h-benzo(a)phenothiazine
12h-7-thia-12-azabenz(a)anthracene
kcp1a0jvz9 ,
unii-kcp1a0jvz9
(12h)-benzo(a)phenothiazine
AKOS022061446
SCHEMBL26797
DTXSID8059760
PGIGZWJIJSINOD-UHFFFAOYSA-N
6,7-benzophenothiazine
7h-benzo[c]phenothiazine #
SR-01000394314-1
sr-01000394314
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (18)

Assay IDTitleYearJournalArticle
AID283915Induction of apoptosis in human MDR1 gene transfected mouse L5178 Y cells assessed as early apoptosis at 50 ug/mL after 40 mins2007Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1
Apoptosis induction and modulation of P-glycoprotein mediated multidrug resistance by new macrocyclic lathyrane-type diterpenoids.
AID704670Induction of cell death in human COLO320 cells preincubated at 200 uM for 40 mins measured after 24 hrs using annexin V/propidium iodide staining by flow cytometry2012Journal of natural products, Nov-26, Volume: 75, Issue:11
Jatrophane diterpenes from Euphorbia mellifera and their activity as P-glycoprotein modulators on multidrug-resistant mouse lymphoma and human colon adenocarcinoma cells.
AID1298983Induction of apoptosis in multi-drug resistant mouse L5178Y cells transfected with human MDR1 assessed as late apoptosis/necrosis at 20 uM after 1 hr by Annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 2.28%)2016Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
Identification of selenocompounds with promising properties to reverse cancer multidrug resistance.
AID1298982Induction of apoptosis in multi-drug resistant mouse L5178Y cells transfected with human MDR1 assessed as early apoptosis at 20 uM after 1 hr by Annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 6.46%)2016Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
Identification of selenocompounds with promising properties to reverse cancer multidrug resistance.
AID1429997Induction of apoptosis in human COLO320 cells assessed as early apoptotic cells at 20 uM after 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 20.3%)2017Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4
Selenoesters and selenoanhydrides as novel multidrug resistance reversing agents: A confirmation study in a colon cancer MDR cell line.
AID1298987Induction of apoptosis in mouse L5178Y cells assessed as early apoptosis at 20 uM after 1 hr by Annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 3.96%)2016Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
Identification of selenocompounds with promising properties to reverse cancer multidrug resistance.
AID283918Induction of apoptosis in human MDR1 gene transfected mouse L5178 Y cells assessed as total apoptosis at 5 ug/mL after 40 mins2007Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1
Apoptosis induction and modulation of P-glycoprotein mediated multidrug resistance by new macrocyclic lathyrane-type diterpenoids.
AID283914Induction of apoptosis in human MDR1 gene transfected mouse L5178 Y cells assessed as early apoptosis at 5 ug/mL after 40 mins2007Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1
Apoptosis induction and modulation of P-glycoprotein mediated multidrug resistance by new macrocyclic lathyrane-type diterpenoids.
AID704789Induction of apoptosis in human COLO320 cells preincubated assessed as late apoptosis at 200 uM for 40 mins measured after 24 hrs using annexin V/propidium iodide staining by flow cytometry2012Journal of natural products, Nov-26, Volume: 75, Issue:11
Jatrophane diterpenes from Euphorbia mellifera and their activity as P-glycoprotein modulators on multidrug-resistant mouse lymphoma and human colon adenocarcinoma cells.
AID704790Induction of apoptosis in human COLO320 cells preincubated assessed as early apoptosis at 200 uM for 40 mins measured after 24 hrs using annexin V/propidium iodide staining by flow cytometry2012Journal of natural products, Nov-26, Volume: 75, Issue:11
Jatrophane diterpenes from Euphorbia mellifera and their activity as P-glycoprotein modulators on multidrug-resistant mouse lymphoma and human colon adenocarcinoma cells.
AID1429999Induction of apoptosis in human COLO320 cells assessed as cell death at 20 uM after 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 4.75%)2017Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4
Selenoesters and selenoanhydrides as novel multidrug resistance reversing agents: A confirmation study in a colon cancer MDR cell line.
AID283919Induction of apoptosis in human MDR1 gene transfected mouse L5178 Y cells assessed as total apoptosis at 50 ug/mL after 40 mins2007Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1
Apoptosis induction and modulation of P-glycoprotein mediated multidrug resistance by new macrocyclic lathyrane-type diterpenoids.
AID1298985Induction of apoptosis in multi-drug resistant mouse L5178Y cells transfected with human MDR1 assessed as cell death at 20 uM after 1 hr by Annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 0.09%)2016Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
Identification of selenocompounds with promising properties to reverse cancer multidrug resistance.
AID1298992Induction of apoptosis in mouse L5178Y cells assessed as cell death at 20 uM after 1 hr by Annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 0.191%)2016Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
Identification of selenocompounds with promising properties to reverse cancer multidrug resistance.
AID1298990Induction of apoptosis in mouse L5178Y cells assessed as late apoptosis/necrosis at 20 uM after 1 hr by Annexin V-FITC/propidium iodide staining-based flow cytometry (Rvb = 0.859%)2016Bioorganic & medicinal chemistry letters, Jun-15, Volume: 26, Issue:12
Identification of selenocompounds with promising properties to reverse cancer multidrug resistance.
AID283922Induction of apoptosis in human MDR1 gene transfected mouse L5178 Y cells assessed as necrosis at 5 ug/mL after 40 mins2007Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1
Apoptosis induction and modulation of P-glycoprotein mediated multidrug resistance by new macrocyclic lathyrane-type diterpenoids.
AID283923Induction of apoptosis in human MDR1 gene transfected mouse L5178 Y cells assessed as necrosis at 50 ug/mL after 40 mins2007Bioorganic & medicinal chemistry, Jan-01, Volume: 15, Issue:1
Apoptosis induction and modulation of P-glycoprotein mediated multidrug resistance by new macrocyclic lathyrane-type diterpenoids.
AID1429998Induction of apoptosis in human COLO320 cells assessed as late apoptotic/necrotic cells at 20 uM after 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry (Rvb = 9.93%)2017Bioorganic & medicinal chemistry letters, 02-15, Volume: 27, Issue:4
Selenoesters and selenoanhydrides as novel multidrug resistance reversing agents: A confirmation study in a colon cancer MDR cell line.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (42.86)29.6817
2010's3 (42.86)24.3611
2020's1 (14.29)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.98

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.98 (24.57)
Research Supply Index2.64 (2.92)
Research Growth Index4.62 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.98)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (15.38%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other11 (84.62%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
verapamil
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.. verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.. 2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.		340aromatic ether;
nitrile;
polyether;
tertiary amino compound
thioridazine
Thioridazine: A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.. thioridazine : A phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position.		2.1310phenothiazines;
piperidines		alpha-adrenergic antagonist;
dopaminergic antagonist;
EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor;
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor;
first generation antipsychotic;
H1-receptor antagonist;
serotonergic antagonist
phthalic anhydride
phthalic anhydride : The cyclic dicarboxylic anhydride that is the anhydride of phthalic acid.		2.15102-benzofurans;
cyclic dicarboxylic anhydride		allergen
5-ethylamino-9-diethylaminobenzo(a)phenothiazinium
5-ethylamino-9-diethylaminobenzo(a)phenothiazinium: structure in first source; RN refers to the chloride salt		2.610
potassium cyanate
potassium cyanate: RN given refers to cpd with MF of K-CHNO		2.1510cyanate salt;
one-carbon compound		herbicide
acyclovir
Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.		2102-aminopurines;
oxopurine		antimetabolite;
antiviral drug
ConditionIndicatedRelationship StrengthStudiesTrials
Germinoblastoma
[description not available]		02.0310
Lymphoma
A general term for various neoplastic diseases of the lymphoid tissue.		02.0310
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0310
Cancer of Colon
[description not available]		02.5120
Colonic Neoplasms
Tumors or cancer of the COLON.		02.5120
T-Cell Lymphoma
[description not available]		02.1310
Lymphoma, T-Cell
A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes.		02.1310