Compounds > benzo(a)pyrene-7,8,9,10-tetrol
Page last updated: 2024-12-07

benzo(a)pyrene-7,8,9,10-tetrol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Benzo(a)pyrene-7,8,9,10-tetrol (BaP-tetrol) is a major metabolite of the potent carcinogen benzo(a)pyrene (BaP), a polycyclic aromatic hydrocarbon (PAH) found in environmental pollutants such as cigarette smoke and coal tar. BaP-tetrol is formed in the liver by cytochrome P450 enzymes and is further metabolized by detoxification enzymes. BaP-tetrol is a reactive electrophile that can bind to DNA and other cellular macromolecules, leading to DNA damage and mutations. It has been implicated in the development of cancer, particularly lung cancer. BaP-tetrol is also a potent inducer of oxidative stress, which can contribute to cell death and inflammation. The study of BaP-tetrol is important for understanding the mechanisms of carcinogenesis and for developing strategies to prevent and treat cancer. Its role as a biomarker for exposure to PAHs has been explored, with its presence in biological samples indicating exposure to BaP and potentially other PAHs.'

benzo(a)pyrene-7,8,9,10-tetrol: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID115324
MeSH IDM0202248

Synonyms (5)

Synonym
bp-7,8,9,10-tetrol
benzo[a]pyrene-7,8,9,10-tetrol
73891-82-4
benzo(a)pyrene-7,8,9,10-tetrol
DTXSID50224471
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's7 (77.78)18.2507
2000's2 (22.22)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.90

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.90 (24.57)
Research Supply Index2.30 (2.92)
Research Growth Index4.20 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.90)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
benzene
[no description available]		1.9810aromatic annulene;
benzenes;
volatile organic compound		carcinogenic agent;
environmental contaminant;
non-polar solvent
benzo(a)pyrene
Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.. benzo[a]pyrene : An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.		3.690ortho- and peri-fused polycyclic arenecarcinogenic agent;
mouse metabolite
2-acetylaminofluorene
2-Acetylaminofluorene: A hepatic carcinogen whose mechanism of activation involves N-hydroxylation to the aryl hydroxamic acid followed by enzymatic sulfonation to sulfoxyfluorenylacetamide. It is used to study the carcinogenicity and mutagenicity of aromatic amines.		1.98102-acetamidofluorenesantimitotic;
carcinogenic agent;
epitope;
mutagen
hydrazine
diamine : Any polyamine that contains two amino groups.		1.9810azane;
hydrazines		EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
7,8-dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide: 7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.		2.940epoxideintercalator
deoxyguanosine
[no description available]		2.3920purine 2'-deoxyribonucleoside;
purines 2'-deoxy-D-ribonucleoside		Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
n-(deoxyguanosin-8-yl)-2-aminofluorene
N-(deoxyguanosin-8-yl)-2-aminofluorene : Guanosine substituted at the purine 8-position by a (9H-fluoren-2-yl)amino group.		1.9810guanosines
phosphorus radioisotopes
Phosphorus Radioisotopes: Unstable isotopes of phosphorus that decay or disintegrate emitting radiation. P atoms with atomic weights 28-34 except 31 are radioactive phosphorus isotopes.		1.9810
ConditionIndicatedRelationship StrengthStudiesTrials
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		01.9910
Disease, Pulmonary
[description not available]		01.9810
Cancer of Lung
[description not available]		01.9810
Lung Diseases
Pathological processes involving any part of the LUNG.		01.9810
Lung Neoplasms
Tumors or cancer of the LUNG.		01.9810