Page last updated: 2024-12-11
benzilylcholine mustard
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
benzilylcholine mustard: alkylating nitrogen mustard analog with specific affinity for cholinergic muscarinic receptors; the combination is irreversible & used to label & study cholinergic receptor sites; minor descriptor (77-86); online & INDEX MEDICUS search CHOLINE/AA (77-86); RN refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 6453495 |
| MeSH ID | M0263121 |
Synonyms (11)
| Synonym |
|---|
| benzilylcholine mustard |
| 2-[2-chloroethyl(methyl)amino]ethyl 2-hydroxy-2,2-diphenylacetate |
| benzeneacetic acid, alpha-hydroxy-alpha-phenyl-, 2-((2-chloroethyl)methylamino)ethyl ester |
| 5746-42-9 |
| unii-3kyg5u8pyv |
| 3kyg5u8pyv , |
| 2((2-chloroethyl)methylamino)ethylbenzylate |
| DTXSID50206070 |
| Q4890771 |
| benzilic acid, 2-((2-chloroethyl)methylamino)ethyl ester |
| ethanol, 2-((2-chloroethyl)methylamino)-, benzilate (ester) |
Research Excerpts
Dosage Studied
| Excerpt | Relevance | Reference |
|---|---|---|
| " We have attempted to determine the occupancy-response relationships of three muscarinic agonists (carbachol, arecoline, and pilocarpine) by comparing their dose-response curves in these preparations with occupancy curves obtained under the same conditions." | ( Muscarinic acetylcholine receptors linked to the inhibition of adenylate cyclase activity in membranes from the rat striatum and myocardium can be distinguished on the basis of agonist efficacy. Keen, M; Nahorski, SR, 1988) | 0.27 |
| "A comparison was made of muscarinic receptor occupancy by the irreversible antagonist benzilylcholine mustard (BCM) as determined from shifts in the dose-response curve to a muscarinic agonist and from 3H-QNB binding to homogenates of BCM-treated tissue." | ( Benzilylcholine mustard and spare receptors in guinea pig ileum. Siegel, H; Triggle, DJ, 1982) | 1.93 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Research
Studies (7)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.43
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.43) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||