Benzestrol is a synthetic nonsteroidal estrogen that was formerly used as a medication for estrogen deficiency and to prevent miscarriage. It is a potent estrogen, but it has been associated with several adverse effects, including an increased risk of endometrial cancer and stroke. It is no longer widely used due to these concerns. Benzestrol is chemically similar to diethylstilbestrol (DES) and shares some of its properties. It was synthesized in the 1940s and marketed under various brand names, including Stilbetin and Dienestrol. It is studied to understand its effects and mechanisms of action as well as to explore its potential use in other areas, such as cancer treatment. While benzestrol is not currently used in medicine, it serves as a valuable tool for research into the mechanisms of action of estrogen.'
| ID Source | ID |
|---|---|
| PubMed CID | 6827 |
| CHEMBL ID | 2104644 |
| CHEBI ID | 135264 |
| SCHEMBL ID | 554391 |
| MeSH ID | M0073757 |
| Synonym |
|---|
| nsc-408889 |
| chemestrogen |
| nsc408889 |
| benzestrol |
| CHEBI:135264 |
| 4-[3-ethyl-4-(4-hydroxyphenyl)hexan-2-yl]phenol |
| FT-0662567 |
| 85-95-0 |
| ocestrol |
| CHEMBL2104644 |
| benzestrol [usp:inn:ban] |
| benzoestrolum |
| benzestrolo |
| 4,4'-(1,2-diethyl-3-methyl-1,3-propanediyl)bisphenol |
| phenol, 4,4'-(1,2-diethyl-3-methyl-1,3-propanediyl)bis- |
| ai3-23191 |
| 4,4'-(1,2-diethyl-3-methyltrimethylene)diphenol |
| benzestrolum |
| octoestrolum |
| unii-a27512lr47 |
| a27512lr47 , |
| benzestrolum [inn-latin] |
| benzestrolo [dcit] |
| octofollin |
| benzoestrol |
| benzestrol [mart.] |
| benzestrol [inn] |
| benzestrol [mi] |
| SCHEMBL554391 |
| DUTFBSAKKUNBAL-UHFFFAOYSA-N |
| AKOS030254537 |
| Q4890763 |
| 4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-sulfonylchloride |
| DTXSID50861663 |
| 4,4'-(3-ethylhexane-2,4-diyl)diphenol |
| Class | Description |
|---|---|
| phenylpropanoid | Any organic aromatic compound with a structure based on a phenylpropane skeleton. The class includes naturally occurring phenylpropanoid esters, flavonoids, anthocyanins, coumarins and many small phenolic molecules as well as their semi-synthetic and synthetic analogues. Phenylpropanoids are also precursors of lignin. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 6 (85.71) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (26.80) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (12.50%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (87.50%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||