Page last updated: 2024-12-07

benfurodil

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Benfurodil is a vasodilator that acts primarily on the peripheral arteries and arterioles. Its mechanism of action is complex, but it is believed to involve inhibition of platelet aggregation, reduction of vascular smooth muscle tone, and improvement of microcirculation. Benfurodil has been used to treat peripheral vascular disease, including intermittent claudication and Raynaud's phenomenon. It is also being investigated for its potential therapeutic effects in other conditions, such as erectile dysfunction and cognitive impairment. The synthesis of benfurodil involves a multi-step process starting with the coupling of a benzyl alcohol derivative with an amino acid. Benfurodil has been shown to improve blood flow to the extremities and reduce pain associated with peripheral vascular disease. It is also believed to have anti-inflammatory and antioxidant properties, which may contribute to its therapeutic effects. Benfurodil is an interesting molecule due to its multiple pharmacological actions and its potential therapeutic benefits for a variety of conditions. However, it has been associated with certain side effects, such as headaches, dizziness, and gastrointestinal upset, and its use is not without controversy.'

Cross-References

ID SourceID
PubMed CID103014
MeSH IDM0040133

Synonyms (13)

Synonym
benfurodil
einecs 222-369-9
3448-13-3
4-(2-(1-hydroxyethyl)-3-methyl-5-benzofuryl)furan-2(5h)-one
3-[2-(1-hydroxyethyl)-3-methyl-1-benzofuran-5-yl]-2h-furan-5-one
unii-71dv8dhp4b
71dv8dhp4b ,
4-[2-(1-hydroxyethyl)-3-methyl-5-benzofuryl]furan-2(5h)-one
2(5h)-furanone, 4-(2-(1-hydroxyethyl)-3-methyl-5-benzofuranyl)
Q27265956
4-(2-(1-hydroxyethyl)-3-methylbenzofuran-5-yl)furan-2(5h)-one
DTXSID80956011
4-[2-(1-hydroxyethyl)-3-methyl-1-benzofuran-5-yl]furan-2(5h)-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (4)

TimeframeStudies, This Drug (%)All Drugs %
pre-19904 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.37

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.37 (24.57)
Research Supply Index2.08 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.37)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (16.67%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (83.33%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]