Page last updated: 2024-12-07
benfurodil
Benfurodil is a vasodilator that acts primarily on the peripheral arteries and arterioles. Its mechanism of action is complex, but it is believed to involve inhibition of platelet aggregation, reduction of vascular smooth muscle tone, and improvement of microcirculation. Benfurodil has been used to treat peripheral vascular disease, including intermittent claudication and Raynaud's phenomenon. It is also being investigated for its potential therapeutic effects in other conditions, such as erectile dysfunction and cognitive impairment. The synthesis of benfurodil involves a multi-step process starting with the coupling of a benzyl alcohol derivative with an amino acid. Benfurodil has been shown to improve blood flow to the extremities and reduce pain associated with peripheral vascular disease. It is also believed to have anti-inflammatory and antioxidant properties, which may contribute to its therapeutic effects. Benfurodil is an interesting molecule due to its multiple pharmacological actions and its potential therapeutic benefits for a variety of conditions. However, it has been associated with certain side effects, such as headaches, dizziness, and gastrointestinal upset, and its use is not without controversy.'
Cross-References
ID Source | ID |
PubMed CID | 103014 |
MeSH ID | M0040133 |
Synonyms (13)
Synonym |
benfurodil |
einecs 222-369-9 |
3448-13-3 |
4-(2-(1-hydroxyethyl)-3-methyl-5-benzofuryl)furan-2(5h)-one |
3-[2-(1-hydroxyethyl)-3-methyl-1-benzofuran-5-yl]-2h-furan-5-one |
unii-71dv8dhp4b |
71dv8dhp4b , |
4-[2-(1-hydroxyethyl)-3-methyl-5-benzofuryl]furan-2(5h)-one |
2(5h)-furanone, 4-(2-(1-hydroxyethyl)-3-methyl-5-benzofuranyl) |
Q27265956 |
4-(2-(1-hydroxyethyl)-3-methylbenzofuran-5-yl)furan-2(5h)-one |
DTXSID80956011 |
4-[2-(1-hydroxyethyl)-3-methyl-1-benzofuran-5-yl]furan-2(5h)-one |
Research
Studies (4)
Timeframe | Studies, This Drug (%) | All Drugs % |
pre-1990 | 4 (100.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.37
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
Metric | This Compound (vs All) |
---|
Research Demand Index | 12.37 (24.57) | Research Supply Index | 2.08 (2.92) | Research Growth Index | 4.45 (4.65) | Search Engine Demand Index | 0.00 (26.88) | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
Trials | 1 (16.67%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 5 (83.33%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |