barakol: a tricyclic 3a,4-dihydro-3a,8-dihydroxy-2,5-dimethyl-1,4-dioxaphenalene ring system [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 3080731 |
| CHEMBL ID | 2164954 |
| MeSH ID | M0280549 |
| Synonym |
|---|
| unii-ezc4abs2mu |
| ezc4abs2mu , |
| 2,5-dimethyl-8h-pyranol(2,3,4-de)-chromen-8-one |
| 24506-68-1 |
| barakol |
| 2,5-dimethyl-3ah-pyrano(2,3,4-de)-1-benzopyran-3a,8-diol |
| 3ah-pyrano(2,3,4-de)-1-benzopyran-3a,8-diol, 2,5-dimethyl- |
| CHEMBL2164954 |
| 2,5-dimethyl-3ah-pyrano[2,3,4-de]-1-benzopyran-3a,8-diol |
| Q4858279 |
| DTXSID30947398 |
| 3,7-dimethyl-2,6-dioxatricyclo[7.3.1.05,13]trideca-1(12),3,7,9(13),10-pentaene-5,11-diol |
| 3ah-pyrano[2,3,4-de]-1-benzopyran-3a,8-diol, 2,5-dimethyl- |
Barakol is a natural anxiolytic extracted from Cassia siamea, known as "Khi-lek" in Thailand. It has been used as a laxative in traditional medicine.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Barakol is a natural anxiolytic extracted from Cassia siamea, known as "Khi-lek" in Thailand. " | ( Acute hepatitis associated with Barakol. Chutaputti, A; Hongsirinirachorn, M; Threeprasertsuk, S, 2003) | 2.05 |
| "Barakol is a purified extract of Cassia siamea, a plant that has been used as a laxative in traditional medicine. " | ( Barakol extracted from Cassia siamea stimulates chloride secretion in rat colon. Deachapunya, C; Krishnamra, N; Poonyachoti, S; Thongsaard, W, 2005) | 3.21 |
| "Barakol is an active compound extracted from the leaves and flowers of the plant called Cassia siamea grown widely in Southeast Asia. " | ( Determination of barakol extracted from Cassia siamea by HPLC with electrochemical detection. Bennett, GW; Chainakul, S; Marsden, CA; Thongsaard, W, 2001) | 2.09 |
Barakol may produce a purgative action in small intestine which may be clinically important in patients with intestinal hypomotility disorders.
| Excerpt | Reference | Relevance |
|---|---|---|
| "The barakol-stimulated increase in Isc was inhibited by subsequent treatment with 500 microM diphenylamine-2-carboxylic acid or 400 microM glibenclamide added to the apical solution and 200 microM bumetanide added to the basolateral solution." | ( Barakol extracted from Cassia siamea stimulates chloride secretion in rat colon. Deachapunya, C; Krishnamra, N; Poonyachoti, S; Thongsaard, W, 2005) | 2.25 |
| "Barakol may produce a purgative action in small intestine which may be clinically important in patients with intestinal hypomotility disorders." | ( Barakol suppresses norepinephrine-induced inhibition of spontaneous longitudinal smooth muscle contractions in isolated rat small intestine. Deachapunya, C; Poonyachoti, S; Thongsaard, W, 2005) | 2.49 |
| Excerpt | Reference | Relevance |
|---|---|---|
| "Treatment with barakol decreased cell viability in a concentration- and time-dependent manner with an IC(50) value of 1.5mM in 24-h treated cells. " | ( Barakol-induced apoptosis in P19 cells through generation of reactive oxygen species and activation of caspase-9. Chaichantipyuth, C; Chanvorachote, P; Hutamekalin, P; Lipipun, V; Meksuriyen, D; Tiensiwakul, P; Wongtongtair, S, 2011) | 2.16 |
| Excerpt | Relevance | Reference |
|---|---|---|
| " The purpose of the present study was to replicate and extend these findings by examining the dose-response effects of barakol (0-20 mg/kg) in two pharmacologically validated tests of rat anxiety: the elevated plus-maze and the shock-probe burying tests." | ( Is barakol anxiolytic? Fiorino, DF; Lermer, L; Menard, J; Phillips, AG; Treit, D, 1998) | 1.13 |
| " Three asymptomatic cases were detected with increased aminotransferase from a routine check-up, including an 81 year old female who took half of the dosage for 120 days." | ( Acute hepatitis associated with Barakol. Chutaputti, A; Hongsirinirachorn, M; Threeprasertsuk, S, 2003) | 0.6 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID696750 | Therapeutic index, ratio of CC50 for human C8166 cells to EC50 for HIV1 | 2012 | Journal of natural products, Nov-26, Volume: 75, Issue:11 | Antiviral chromones from the stem of Cassia siamea. |
| AID696752 | Antiviral activity against HIV1 infected in human C8166 cells assessed as inhibition of virus-induced cytopathic effect | 2012 | Journal of natural products, Nov-26, Volume: 75, Issue:11 | Antiviral chromones from the stem of Cassia siamea. |
| AID696760 | Antiviral activity against Tobacco mosaic virus infected in right side leaf of Nicotiana glutinosa at 20 uM after 3 to 4 days by half-leaf method | 2012 | Journal of natural products, Nov-26, Volume: 75, Issue:11 | Antiviral chromones from the stem of Cassia siamea. |
| AID696751 | Cytotoxicity against human C8166 cells by MTT assay | 2012 | Journal of natural products, Nov-26, Volume: 75, Issue:11 | Antiviral chromones from the stem of Cassia siamea. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (21.43) | 18.2507 |
| 2000's | 9 (64.29) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (29.12) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 14 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||