azoprocarbazine profile

Azoprocarbazine is an experimental anticancer drug that is a derivative of the antitumor agent procarbazine. It is a potent inhibitor of DNA synthesis and cell proliferation. Azoprocarbazine has shown promising activity in preclinical models of cancer, including leukemia, lymphoma, and solid tumors. The mechanism of action of azoprocarbazine is thought to involve the generation of reactive oxygen species, which damage DNA and lead to cell death. Azoprocarbazine is currently in clinical trials for the treatment of various types of cancer. This compound is studied due to its potential as a novel therapeutic agent for cancer. Research focuses on understanding its mechanism of action, its efficacy in treating different cancers, and its potential toxicity.'

azoprocarbazine: oxidative metabolite of procarbazine [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	75230
MeSH ID	M0090849

Synonym
brn 2648551
azo-natulan
p-toluamide, n-isopropyl-alpha-(methylazo)-
ccris 1267
benzamide, 4-((methylazo)methyl)-n-(1-methylethyl)-
p-toluamide, n-isopropyl-alpha-(2-methylazo)-
azoprocarbazine
n-isopropyl-alpha-(2-methylazo)-p-toluamide
4-[(methyldiazenyl)methyl]-n-propan-2-ylbenzamide
2235-59-8
56768ks32d ,
unii-56768ks32d
n-isopropyl-.alpha.-(2-methylazo)-p-toluamide
4-[methylazomethyl]-n-isopropyl-benzamid
4-[(2-methyldiazenyl)methyl]-n-(1-methylethyl)benzamide
DTXSID101206856
Q27261380

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (55.56)	18.7374
1990's	2 (22.22)	18.2507
2000's	2 (22.22)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	10 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
methane Methane: The simplest saturated hydrocarbon. It is a colorless, flammable gas, slightly soluble in water. It is one of the chief constituents of natural gas and is formed in the decomposition of organic matter. (Grant & Hackh's Chemical Dictionary, 5th ed). methane : A one-carbon compound in which the carbon is attached by single bonds to four hydrogen atoms. It is a colourless, odourless, non-toxic but flammable gas (b.p. -161degreeC).	2.37	2	alkane; gas molecular entity; mononuclear parent hydride; one-carbon compound	bacterial metabolite; fossil fuel; greenhouse gas
phenytoin [no description available]	1.96	1	imidazolidine-2,4-dione	anticonvulsant; drug allergen; sodium channel blocker; teratogenic agent
phenobarbital Phenobarbital: A barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.. phenobarbital : A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.	2.36	2	barbiturates	anticonvulsant; drug allergen; excitatory amino acid antagonist; sedative
procarbazine Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.. procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.	3.58	9	benzamides; hydrazines	antineoplastic agent
monomethylhydrazine Monomethylhydrazine: Hydrazine substituted by one methyl group.	2.38	2
methylprednisolone Methylprednisolone: A PREDNISOLONE derivative with similar anti-inflammatory action.. 6alpha-methylprednisolone : The 6alpha-stereoisomer of 6-methylprednisolone.	1.96	1	6-methylprednisolone; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	adrenergic agent; anti-inflammatory drug; antiemetic; environmental contaminant; neuroprotective agent; xenobiotic
benzylamine aminotoluene : Any member of the class of toluenes carrying one or more amino groups.	1.98	1	aralkylamine; primary amine	allergen; EC 3.5.5.1 (nitrilase) inhibitor; plant metabolite
hydrazine diamine : Any polyamine that contains two amino groups.	2.04	1	azane; hydrazines	EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
nadp [no description available]	1.98	1

Condition	Relationship Strength	Studies
Benign Neoplasms [description not available]	2.03	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.03	1
Malignant Melanoma [description not available]	2.04	1
Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	2.04	1
Leukemia L 1210 [description not available]	1.96	1

azoprocarbazine

Description

Cross-References

Synonyms (17)

Research

Studies (9)

Study Types