Page last updated: 2024-12-06
azelaic bishydroxamic acid
Description
Azelaic bishydroxamic acid (ABHA) is a synthetic derivative of azelaic acid, a naturally occurring dicarboxylic acid found in wheat, rye, and barley. ABHA exhibits a broad spectrum of biological activities, including antimicrobial, anti-inflammatory, and anticancer properties. Its unique chemical structure, containing two hydroxamic acid groups, contributes to its potent inhibitory effects on various enzymes, such as histone deacetylases (HDACs), matrix metalloproteinases (MMPs), and tyrosinase. ABHA has been studied extensively for its potential therapeutic applications in treating skin conditions like acne, rosacea, and hyperpigmentation. Its mechanism of action involves inhibiting sebum production, reducing inflammation, and promoting skin cell renewal. The compound's ability to target multiple signaling pathways and enzyme activities makes it a promising candidate for developing novel therapeutic strategies against a range of diseases.'
azelaic bishydroxamic acid: InChIKey: VBJZDMOTYJEHEP-UHFFFAOYSA-N [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|
| PubMed CID | 65268 |
| CHEMBL ID | 495390 |
| SCHEMBL ID | 4741072 |
| MeSH ID | M0279974 |
Synonyms (17)
| Synonym |
|---|
| nsc611775 |
| nsc-611775 |
| azelaic bishydroxamic acid |
| n,n'-dihydroxynonanediamide |
| CHEMBL495390 |
| azelaic bis hydroxamic acid |
| 18992-11-5 |
| unii-dd5h4vk8jm |
| azelaic bis(hydroxamic acid) |
| dd5h4vk8jm , |
| nonanediamide, n,n'-dihydroxy- |
| SCHEMBL4741072 |
| DTXSID30172421 |
| nonanediamide, n1,n9-dihydroxy- |
| azeladihydroxamic acid |
| azelahydroximic acid |
| n1,n9-dihydroxynonanediamide |
Bioassays (3)
| Assay ID | Title | Year | Journal | Article |
|---|
| AID382113 | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by LDH reporter assay | 2008 | Bioorganic & medicinal chemistry, May-01, Volume: 16, Issue:9
| Structural insights into the Plasmodium falciparum histone deacetylase 1 (PfHDAC-1): A novel target for the development of antimalarial therapy. |
| AID382112 | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 after 48 hrs by LDH reporter assay | 2008 | Bioorganic & medicinal chemistry, May-01, Volume: 16, Issue:9
| Structural insights into the Plasmodium falciparum histone deacetylase 1 (PfHDAC-1): A novel target for the development of antimalarial therapy. |
| AID519582 | Antimalarial activity against Plasmodium falciparum | 2008 | Antimicrobial agents and chemotherapy, Apr, Volume: 52, Issue:4
| Potent antimalarial activity of histone deacetylase inhibitor analogues. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (10)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (10.00) | 18.2507 |
| 2000's | 9 (90.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.19
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| Metric | This Compound (vs All) |
|---|
| Research Demand Index | 12.19 (24.57) | | Research Supply Index | 2.40 (2.92) | | Research Growth Index | 4.59 (4.65) | | Search Engine Demand Index | 0.00 (26.88) | | Search Engine Supply Index | 0.00 (0.95) |
| |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 10 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |