aucuparin: biphenyl phytoalexin in Sorbus aucuparia cell cultures; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Aucuparia | genus | [no description available] | Rosaceae | The rose plant family in the order ROSALES and class Magnoliopsida. They are generally woody plants. A number of the species of this family contain cyanogenic compounds.[MeSH] |
| Sorbus aucuparia | species | [no description available] | Rosaceae | The rose plant family in the order ROSALES and class Magnoliopsida. They are generally woody plants. A number of the species of this family contain cyanogenic compounds.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 442508 |
| CHEMBL ID | 1079777 |
| CHEBI ID | 2920 |
| SCHEMBL ID | 11223391 |
| MeSH ID | M000595007 |
| Synonym |
|---|
| (1,1'-biphenyl)-4-ol, 3,5-dimethoxy- |
| unii-18ic7401l0 |
| 18ic7401l0 , |
| 2,6-dimethoxy-4-phenylphenol |
| 2,6-dimethoxy-4-phenyl-phenol |
| 3,5-dimethoxy-(1,1'-biphenyl)-4-ol |
| aucuparin |
| C09918 , |
| 3687-28-3 |
| AC1L9CZ5 , |
| chebi:2920 , |
| CHEMBL1079777 |
| (1,1-biphenyl)-4-ol, 3,5-dimethoxy- |
| phenol, 2,6-dimethoxy-4-phenyl- |
| SCHEMBL11223391 |
| surecn11223391 |
| DTXSID40190353 |
| AKOS030531275 |
| 4-hydroxy-3,5-dimethoxybiphenyl |
| Q27105881 |
| HY-137992 |
| CS-0143554 |
| aucaparin |
| Class | Description |
|---|---|
| biphenyls | Benzenoid aromatic compounds containing two phenyl or substituted-phenyl groups which are joined together by a single bond. |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Pathway | Proteins | Compounds |
|---|---|---|
| aucuparin biosynthesis | 6 | 12 |
| aucuparin biosynthesis | 6 | 13 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID471757 | Cytotoxicity against human SKOV3 cells by SRB assay | 2009 | Journal of natural products, Nov, Volume: 72, Issue:11 | Biphenyls from Berberis koreana. |
| AID471756 | Cytotoxicity against human A549 cells by SRB assay | 2009 | Journal of natural products, Nov, Volume: 72, Issue:11 | Biphenyls from Berberis koreana. |
| AID471759 | Cytotoxicity against human HCT15 cells by SRB assay | 2009 | Journal of natural products, Nov, Volume: 72, Issue:11 | Biphenyls from Berberis koreana. |
| AID1269183 | Stimulation of NGF secretion in rat C6 cells at 20 uM after 24 hrs by ELISA | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Isolation of bioactive biphenyl compounds from the twigs of Chaenomeles sinensis. |
| AID1269181 | Anti-neuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced NO production after 24 hrs by Griess assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Isolation of bioactive biphenyl compounds from the twigs of Chaenomeles sinensis. |
| AID1269182 | Cytotoxicity against mouse BV2 cells assessed as viable cells at 20 uM by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Isolation of bioactive biphenyl compounds from the twigs of Chaenomeles sinensis. |
| AID471758 | Cytotoxicity against human SK-MEL-2 cells by SRB assay | 2009 | Journal of natural products, Nov, Volume: 72, Issue:11 | Biphenyls from Berberis koreana. |
| AID1269184 | Cytotoxicity against rat C6 cells assessed as viable cells at 20 uM by MTT assay | 2016 | Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2 | Isolation of bioactive biphenyl compounds from the twigs of Chaenomeles sinensis. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (13.16) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 7 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||