Page last updated: 2024-12-07
at 2433-a1
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
AT 2433-A1: isolated from Actinomadura melliaura; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 128141 |
| CHEMBL ID | 3589063 |
| MeSH ID | M0171438 |
Synonyms (6)
| Synonym |
|---|
| at2433-a1 |
| 102644-20-2 |
| at 2433-a1 |
| 5h-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6h)-dione, 1-chloro-13-(6-o-(2,4-dideoxy-4-(methylamino)pentopyranosyl)-4-o-methylhexopyranosyl)-12,13-dihydro-6-methyl- |
| CHEMBL3589063 |
| 5-chloro-3-[(2r,3r,4r,5s,6r)-3,4-dihydroxy-6-[[(2s,4s,5s)-4-hydroxy-5-(methylamino)oxan-2-yl]oxymethyl]-5-methoxyoxan-2-yl]-13-methyl-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17,19,21-nonaene-12,14-dione |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (12)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1233756 | Cytotoxic activity against human PC3 cells assessed as reduction in cell viability incubated for 72 hrs | 2015 | Journal of natural products, Jul-24, Volume: 78, Issue:7 | Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691. |
| AID1233757 | Cytotoxic activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs | 2015 | Journal of natural products, Jul-24, Volume: 78, Issue:7 | Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691. |
| AID1233746 | Antimicrobial activity against Mycobacterium smegmatis ATCC 14468 assessed as inhibition of microbial growth incubated for 16 to 48 hrs | 2015 | Journal of natural products, Jul-24, Volume: 78, Issue:7 | Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691. |
| AID1233754 | Cytotoxic activity against human A549 cells assessed as cell viability at 10 uM incubated for 72 hrs | 2015 | Journal of natural products, Jul-24, Volume: 78, Issue:7 | Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691. |
| AID1233749 | Antimicrobial activity against Escherichia coli NRRL B-3708 assessed as inhibition of microbial growth up to 60 uM incubated for 16 to 48 hrs | 2015 | Journal of natural products, Jul-24, Volume: 78, Issue:7 | Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691. |
| AID1233747 | Antimicrobial activity against Salmonella enterica ATCC 10708 assessed as inhibition of microbial growth up to 60 uM incubated for 16 to 48 hrs | 2015 | Journal of natural products, Jul-24, Volume: 78, Issue:7 | Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691. |
| AID1233744 | Antimicrobial activity against Micrococcus luteus NRRL B-287 assessed as inhibition of microbial growth incubated for 16 to 48 hrs | 2015 | Journal of natural products, Jul-24, Volume: 78, Issue:7 | Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691. |
| AID1233758 | Cytotoxic activity against human U118MG cells assessed as reduction in cell viability incubated for 72 hrs | 2015 | Journal of natural products, Jul-24, Volume: 78, Issue:7 | Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691. |
| AID1233745 | Antimicrobial activity against Saccharomyces cerevisiae ATCC 204508 assessed as inhibition of microbial growth incubated for 24 hrs | 2015 | Journal of natural products, Jul-24, Volume: 78, Issue:7 | Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691. |
| AID1233755 | Cytotoxic activity against human U118MG cells assessed as cell viability at 10 uM incubated for 72 hrs | 2015 | Journal of natural products, Jul-24, Volume: 78, Issue:7 | Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691. |
| AID1233743 | Antimicrobial activity against Staphylococcus aureus ATCC 6538 assessed as inhibition of microbial growth incubated for 16 to 48 hrs | 2015 | Journal of natural products, Jul-24, Volume: 78, Issue:7 | Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691. |
| AID1233753 | Cytotoxic activity against human PC3 cells assessed as cell viability at 10 uM incubated for 72 hrs | 2015 | Journal of natural products, Jul-24, Volume: 78, Issue:7 | Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 12.63
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.63) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||