Compounds > at 2433-a1
Page last updated: 2024-11-07

at 2433-a1

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

AT 2433-A1: isolated from Actinomadura melliaura; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID128141
CHEMBL ID3589063
MeSH IDM0171438

Synonyms (6)

Synonym
at2433-a1
102644-20-2
at 2433-a1
5h-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6h)-dione, 1-chloro-13-(6-o-(2,4-dideoxy-4-(methylamino)pentopyranosyl)-4-o-methylhexopyranosyl)-12,13-dihydro-6-methyl-
CHEMBL3589063
5-chloro-3-[(2r,3r,4r,5s,6r)-3,4-dihydroxy-6-[[(2s,4s,5s)-4-hydroxy-5-(methylamino)oxan-2-yl]oxymethyl]-5-methoxyoxan-2-yl]-13-methyl-3,13,23-triazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1,4(9),5,7,10,15,17,19,21-nonaene-12,14-dione
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID1233756Cytotoxic activity against human PC3 cells assessed as reduction in cell viability incubated for 72 hrs2015Journal of natural products, Jul-24, Volume: 78, Issue:7
Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691.
AID1233757Cytotoxic activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs2015Journal of natural products, Jul-24, Volume: 78, Issue:7
Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691.
AID1233746Antimicrobial activity against Mycobacterium smegmatis ATCC 14468 assessed as inhibition of microbial growth incubated for 16 to 48 hrs2015Journal of natural products, Jul-24, Volume: 78, Issue:7
Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691.
AID1233754Cytotoxic activity against human A549 cells assessed as cell viability at 10 uM incubated for 72 hrs2015Journal of natural products, Jul-24, Volume: 78, Issue:7
Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691.
AID1233749Antimicrobial activity against Escherichia coli NRRL B-3708 assessed as inhibition of microbial growth up to 60 uM incubated for 16 to 48 hrs2015Journal of natural products, Jul-24, Volume: 78, Issue:7
Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691.
AID1233747Antimicrobial activity against Salmonella enterica ATCC 10708 assessed as inhibition of microbial growth up to 60 uM incubated for 16 to 48 hrs2015Journal of natural products, Jul-24, Volume: 78, Issue:7
Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691.
AID1233744Antimicrobial activity against Micrococcus luteus NRRL B-287 assessed as inhibition of microbial growth incubated for 16 to 48 hrs2015Journal of natural products, Jul-24, Volume: 78, Issue:7
Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691.
AID1233758Cytotoxic activity against human U118MG cells assessed as reduction in cell viability incubated for 72 hrs2015Journal of natural products, Jul-24, Volume: 78, Issue:7
Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691.
AID1233745Antimicrobial activity against Saccharomyces cerevisiae ATCC 204508 assessed as inhibition of microbial growth incubated for 24 hrs2015Journal of natural products, Jul-24, Volume: 78, Issue:7
Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691.
AID1233755Cytotoxic activity against human U118MG cells assessed as cell viability at 10 uM incubated for 72 hrs2015Journal of natural products, Jul-24, Volume: 78, Issue:7
Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691.
AID1233743Antimicrobial activity against Staphylococcus aureus ATCC 6538 assessed as inhibition of microbial growth incubated for 16 to 48 hrs2015Journal of natural products, Jul-24, Volume: 78, Issue:7
Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691.
AID1233753Cytotoxic activity against human PC3 cells assessed as cell viability at 10 uM incubated for 72 hrs2015Journal of natural products, Jul-24, Volume: 78, Issue:7
Cytotoxic Indolocarbazoles from Actinomadura melliaura ATCC 39691.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19902 (40.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.63

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.63 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.42 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.63)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
at 2433-b1
AT 2433-B1: indolocarbazole from Actinomadura melliaura; iso-AT2433-B1 is a diastereoisomer; structure in first source		2.6730
mannich bases
Mannich Bases: Ketonic amines prepared from the condensation of a ketone with formaldehyde and ammonia or a primary or secondary amine. A Mannich base can act as the equivalent of an alpha,beta unsaturated ketone in synthesis or can be reduced to form physiologically active amino alcohols.		210
ConditionIndicatedRelationship StrengthStudiesTrials
Leukemia P388
An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.		01.9710