Compounds > androst-16-en-3-ol
Page last updated: 2024-11-07

androst-16-en-3-ol

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Cross-References

ID SourceID
PubMed CID101989
CHEMBL ID142348
CHEBI ID40933
SCHEMBL ID324888
MeSH IDM0044573

Synonyms (51)

Synonym
androst-16-en-3-ol
androst-16-en-3-ol, (3alpha,5alpha)-
nsc 71076
unii-48k9vam062
einecs 214-573-1
48k9vam062 ,
gtpl2761
alpha-androstenol
LMST02020008
androst-16-en-3alpha-ol
1153-51-1
5.alpha.-androst-16-en-3.alpha.-ol
androst-16-en-3-ol,5.alpha.)-
3.alpha.-hydroxyandrost-16-ene
nsc71076
nsc-71076
16,17-androstene-3-ol
5alpha-androst-16-en-3alpha-ol, >=98%
5alpha-androst-16-en-3alpha-ol
androstenol
3alpha-hydroxyandrost-16-ene
(3alpha,5alpha)-androst-16-en-3-ol
CHEBI:40933 ,
DB01889
SPECTRUM5_002029
bdbm50134722
CHEMBL142348 ,
(3r,5s,8r,9s,10s,13r,14s)-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15-dodecahydro-1h-cyclopenta[a]phenanthren-3-ol
5-alpha-androst-16-en-3-alpha-ol
androst-16-en-3-ol, (3a,5a)-
5|a-androst-16-en-3|a-ol
androst-16-en-3-ol, (3.alpha.,5.alpha.)-
1XNX
BRD-K24994810-001-01-9
3.alpha.-hydroxy-5.alpha.-androst-16-ene
(3.alpha.,5.alpha.)-androst-16-en-3-ol [mi]
AKOS017343734
SCHEMBL324888
5.alpha.-androst-16-ene-3.alpha.-ol
androst-16-en-3-ol #
DTXSID2075394
(3r,5s,8r,9s,10s,13r,14s)-10,13-dimethyl-2,3,4,5,6,7,8,9,10,11,12,13,14,15-tetradecahydro-1h-cyclopenta[a]phenanthren-3-ol
(3a,5a)-androst-16-en-3-ol
3a-hydroxy-5a-androst-16-ene
3a-hydroxyandrost-16-ene
3a-hydroxyandrostene
5a-androst-16-en-3a-ol
(3beta,5alpha)-androst-16-en-3-ol
Q2567125
3-hydroxy-5-androst-16-ene
(3as,3br,5as,7r,9as,9bs,11ar)-9a,11a-dimethyl-3h,3ah,3bh,4h,5h,5ah,6h,7h,8h,9h,9ah,9bh,10h,11h,11ah-cyclopenta[a]phenanthren-7-ol
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
pheromoneA semiochemical used in olfactory communication between organisms of the same species eliciting a change in sexual or social behaviour.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
3alpha-sterol
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (1)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Nuclear receptor subfamily 1 group I member 3Mus musculus (house mouse)IC50 (µMol)0.25000.25000.25000.2500AID50905
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (39)

Assay IDTitleYearJournalArticle
AID345575Decrease in mouse CAR L253F mutant activation expressed in HEK293 cells at 10 uM by mammalian one-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345669Decrease in nuclear co-repressor receptor binding to mouse CAR T350M mutant expressed in HEK293 cells at 10 uM by yeast two-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345666Effect on steroid receptor coactivator 1 binding to mouse CAR T350A mutant expressed in HEK293 cells at 10 uM by yeast two-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345683Cytotoxicity against HEK293 cells2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345628Decrease in nuclear co-repressor receptor binding to mouse CAR H213A mutant expressed in HEK293 cells at 10 uM by yeast two-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345621Effect on steroid receptor co-activator 1 binding to mouse CAR L212A mutant expressed in HEK293 cells at 10 uM by yeast two-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345589Effect on mouse CAR T350M mutant expressed in HEK293 cells at 2 uM by mammalian one-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345641Enhancement of steroid receptor coactivator 1 binding to mouse CAR I252L mutant expressed in HEK293 cells at 10 uM by yeast two-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345645Effect on steroid receptor coactivator 1 binding to mouse CAR I252L mutant expressed in HEK293 cells at 10 uM by yeast two-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345655Decrease in nuclear co-repressor receptor binding to mouse CAR Y336A mutant expressed in HEK293 cells at 10 uM by yeast two-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345634Decrease in nuclear co-repressor receptor binding to mouse CAR S251L mutant expressed in HEK293 cells at 10 uM by yeast two-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345651Effect on steroid receptor coactivator 1 binding to mouse CAR L253F mutant expressed in HEK293 cells at 10 uM by yeast two-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345619Decrease in nuclear co-repressor receptor binding to mouse CAR L212A mutant expressed in HEK293 cells at 10 uM by yeast two-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345543Enhancement of steroid receptor coactivator 1 binding to wild type mouse CAR expressed in HEK293 cells at 10 uM by yeast two-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345636Effect on steroid receptor coactivator 1 binding to mouse CAR S251L mutant expressed in HEK293 cells at 10 uM by yeast two-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345540Decrease in wild type mouse CAR activation expressed in HEK293 cells at 10 uM by mammalian one-hybrid transactivation assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345546Increase in nuclear co-repressor receptor binding to wild type mouse CAR expressed in HEK293 cells at 10 uM by yeast two-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345660Effect on steroid receptor coactivator 1 binding to mouse CAR Y336A mutant expressed in HEK293 cells at 10 uM by yeast two-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345611Decrease in nuclear co-repressor receptor binding to mouse CAR N175A mutant expressed in HEK293 cells at 10 uM by yeast two-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345607Effect on steroid receptor co-activator 1 binding to mouse CAR F171L mutant expressed in HEK293 cells at 10 uM by yeast two-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345676Decrease in nuclear co-repressor receptor binding to mouse CAR L353A mutant expressed in HEK293 cells at 10 uM by yeast two-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345614Enhancement of steroid receptor co-activator 1 binding to mouse CAR N175A mutant expressed in HEK293 cells at 10 uM by yeast two-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345572Decrease in mouse CAR I252L mutant activation expressed in HEK293 cells at 10 uM by mammalian one-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345604Decrease in nuclear co-repressor receptor binding to mouse CAR F171L mutant expressed in HEK293 cells at 10 uM by yeast two-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345663Decrease in nuclear co-repressor receptor binding to mouse CAR T350A mutant expressed in HEK293 cells at 10 uM by yeast two-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345599Effect on steroid receptor co-activator 1 binding to mouse CAR F171A mutant expressed in HEK293 cells at 10 uM by yeast two-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345569Activation of mouse CAR S251L mutant expressed in HEK293 cells at 10 uM by mammalian one-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345672Effect on steroid receptor coactivator 1 binding to mouse CAR T350M mutant expressed in HEK293 cells at 10 uM by yeast two-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345681Effect on steroid receptor coactivator 1 binding to mouse CAR L353A mutant expressed in HEK293 cells at 10 uM by yeast two-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345579Decrease in mouse CAR Y336A mutant activation expressed in HEK293 cells at 10 uM by mammalian one-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345593Decrease in nuclear co-repressor receptor binding to mouse CAR F171A mutant expressed in HEK293 cells at 10 uM by yeast two-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345648Decrease in nuclear co-repressor receptor binding to mouse CAR L253F mutant expressed in HEK293 cells at 10 uM by yeast two-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID50905Inhibitory concentration against mammalian m-constitutive androstane receptor (mCAR) activity2003Journal of medicinal chemistry, Oct-23, Volume: 46, Issue:22
Molecular determinants of steroid inhibition for the mouse constitutive androstane receptor.
AID345561Decrease in mouse CAR L212A mutant activation expressed in HEK293 cells at 10 uM by mammalian one-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345631Effect on steroid receptor coactivator 1 binding to mouse CAR H213A mutant expressed in HEK293 cells at 10 uM by yeast two-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345585Activation of mouse CAR T350A mutant expressed in HEK293 cells at 10 uM by mammalian one-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID345552Decrease in mouse CAR F171L mutant activation expressed in HEK293 cells at 10 uM by mammalian one-hybrid assay2008Journal of medicinal chemistry, Nov-27, Volume: 51, Issue:22
Ligand specificity of constitutive androstane receptor as probed by induced-fit docking and mutagenesis.
AID1346793Mouse Constitutive androstane receptor (1I. Vitamin D receptor-like receptors)1998Nature, Oct-08, Volume: 395, Issue:6702
Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta.
AID977610Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB2003Journal of medicinal chemistry, Oct-23, Volume: 46, Issue:22
Molecular determinants of steroid inhibition for the mouse constitutive androstane receptor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (19)

TimeframeStudies, This Drug (%)All Drugs %
pre-19908 (42.11)18.7374
1990's3 (15.79)18.2507
2000's6 (31.58)29.6817
2010's2 (10.53)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.18

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.18 (24.57)
Research Supply Index3.09 (2.92)
Research Growth Index4.27 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.18)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (10.53%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (89.47%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
bromide
Bromides: Salts of hydrobromic acid, HBr, with the bromine atom in the 1- oxidation state. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)		2.1310halide anion;
monoatomic bromine
clotrimazole
[no description available]		2.0410conazole antifungal drug;
imidazole antifungal drug;
imidazoles;
monochlorobenzenes		antiinfective agent;
environmental contaminant;
xenobiotic
methoxychlor
Methoxychlor: An insecticide. Methoxychlor has estrogenic effects in mammals, among other effects.		2.0410organochlorine insecticide
1,4-bis(2-(3,5-dichloropyridyloxy))benzene
1,4-bis(2-(3,5-dichloropyridyloxy))benzene: potent phenobarbital-like inducer of microsomal monooxygenase activity; structure given in first source		2.0410
corticosterone
[no description available]		2.011011beta-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
androsterone
[no description available]		2.011017-oxo steroid;
3alpha-hydroxy steroid;
androstanoid;
C19-steroid		androgen;
anticonvulsant;
human blood serum metabolite;
human metabolite;
human urinary metabolite;
mouse metabolite;
pheromone
dehydroepiandrosterone
Dehydroepiandrosterone: A major C19 steroid produced by the ADRENAL CORTEX. It is also produced in small quantities in the TESTIS and the OVARY. Dehydroepiandrosterone (DHEA) can be converted to TESTOSTERONE; ANDROSTENEDIONE; ESTRADIOL; and ESTRONE. Most of DHEA is sulfated (DEHYDROEPIANDROSTERONE SULFATE) before secretion.. dehydroepiandrosterone : An androstanoid that is androst-5-ene substituted by a beta-hydroxy group at position 3 and an oxo group at position 17. It is a naturally occurring steroid hormone produced by the adrenal glands.		2.362017-oxo steroid;
3beta-hydroxy-Delta(5)-steroid;
androstanoid		androgen;
human metabolite;
mouse metabolite
17-desoxyestradiol
estra-1,3,5(10)-trien-3-ol : A 3-hydroxy steroid resulting from deoxygenation at position 17 of estradiol or estrone.		2.01103-hydroxy steroid;
phenolic steroid;
phenols		estrogen
ethinyl estradiol
Ethinyl Estradiol: A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.. 17alpha-ethynylestradiol : A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.		2.041017-hydroxy steroid;
3-hydroxy steroid;
terminal acetylenic compound		xenoestrogen
androstenedione
Androstenedione: A delta-4 C19 steroid that is produced not only in the TESTIS, but also in the OVARY and the ADRENAL CORTEX. Depending on the tissue type, androstenedione can serve as a precursor to TESTOSTERONE as well as ESTRONE and ESTRADIOL.. androst-4-ene-3,17-dione : A 3-oxo Delta(4)-steroid that is androst-4-ene substituted by oxo groups at positions 3 and 17. It is a steroid hormone synthesized in the adrenal glands and gonads.		2.392017-oxo steroid;
3-oxo-Delta(4) steroid;
androstanoid		androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite
desoxycorticosterone
Desoxycorticosterone: A steroid metabolite that is the 11-deoxy derivative of CORTICOSTERONE and the 21-hydroxy derivative of PROGESTERONE		2.011020-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
mineralocorticoid;
primary alpha-hydroxy ketone		human metabolite;
mouse metabolite
17-alpha-hydroxyprogesterone
17alpha-hydroxyprogesterone : A 17alpha-hydroxy steroid that is the 17alpha-hydroxy derivative of progesterone.		2.011017alpha-hydroxy-C21-steroid;
17alpha-hydroxy steroid;
tertiary alpha-hydroxy ketone		human metabolite;
metabolite;
mouse metabolite;
progestin
pregnenolone
[no description available]		2.392020-oxo steroid;
3beta-hydroxy-Delta(5)-steroid;
C21-steroid		human metabolite;
mouse metabolite
epitestosterone
Epitestosterone: The 17-alpha isomer of TESTOSTERONE, derived from PREGNENOLONE via the delta5-steroid pathway, and via 5-androstene-3-beta,17-alpha-diol. Epitestosterone acts as an antiandrogen in various target tissues. The ratio between testosterone/epitestosterone is used to monitor anabolic drug abuse.. epitestosterone : An androstanoid that is the C-17 epimer of testosterone.		2.011017alpha-hydroxy steroid;
3-oxo-Delta(4) steroid;
androstanoid		androgen antagonist;
human metabolite
dihydrotestosterone
Dihydrotestosterone: A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.. 17beta-hydroxyandrostan-3-one : A 17beta-hydroxy steroid that is testosterone in which the 4-5 double bond has been reduced to a single bond with unspecified configuration at position 5.. 17beta-hydroxy-5alpha-androstan-3-one : A 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5.		2.011017beta-hydroxy steroid;
17beta-hydroxyandrostan-3-one;
3-oxo-5alpha-steroid		androgen;
Daphnia magna metabolite;
human metabolite;
mouse metabolite
formestane
[no description available]		2.011017-oxo steroid;
3-oxo-Delta(4) steroid;
enol;
hydroxy steroid		antineoplastic agent;
EC 1.14.14.14 (aromatase) inhibitor
1,4-androstadiene-3,17-dione
1,4-androstadiene-3,17-dione: structure. androsta-1,4-diene-3,17-dione : A steroid that consists of androstane having double bonds at positions 1 and 4 and two keto groups at positions 3 and 17.		2.011017-oxo steroid;
3-oxo-Delta(1) steroid;
3-oxo-Delta(4) steroid
iridium
Iridium: A metallic element with the atomic symbol Ir, atomic number 77, and atomic weight 192.22.		7.2110cobalt group element atom;
platinum group metal atom
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46.		2.1310metal allergen;
nickel group element atom;
platinum group metal atom
ruthenium
Ruthenium: A hard, brittle, grayish-white rare earth metal with an atomic symbol Ru, atomic number 44, and atomic weight 101.07. It is used as a catalyst and hardener for PLATINUM and PALLADIUM.		7.2110iron group element atom;
platinum group metal atom
5beta-pregnane-3,20-dione
5beta-pregnane-3,20-dione : A C21-steroid that is 5beta-pregnane with oxo groups at positions 3 and 20.		2.011020-oxo steroid;
3-oxo-5beta-steroid;
C21-steroid		human metabolite;
mouse metabolite
brexanolone
brexanolone: a mixture of allopregnanolone and sulfobutylether‐beta‐cyclodextrin for treatment of postpartum depression. brexanolone : A 3-hydroxy-5alpha-pregnan-20-one in which the hydroxy group at position 3 has alpha-configuration. It is a metabolite of the sex hormone progesterone and used for the treatment of postpartum depression in women.		2.01103-hydroxy-5alpha-pregnan-20-oneantidepressant;
GABA modulator;
human metabolite;
intravenous anaesthetic;
sedative
5-alpha-dihydroprogesterone
5-alpha-Dihydroprogesterone: A biologically active 5-alpha-reduced metabolite of plasma PROGESTERONE. It is the immediate precursor of 5-alpha-pregnan-3-alpha-ol-20-one (ALLOPREGNANOLONE), a neuroactive steroid that binds with GABA(A) RECEPTOR.. 5alpha-pregnane-3,20-dione : A C21-steroid hormone that is 5alpha-pregnane substituted by oxo groups at positions 3 and 20. It is a metabolite of progestrone.		2.011020-oxo steroid;
3-oxo-5alpha-steroid;
C21-steroid hormone		human metabolite;
progestogen
androstan-3-ol
[no description available]		1.99103-hydroxy steroidandrogen
4,16-androstadien-3-one
[no description available]		1.9610
cortisone
[no description available]		2.011011-oxo steroid;
17alpha-hydroxy steroid;
20-oxo steroid;
21-hydroxy steroid;
3-oxo-Delta(4) steroid;
C21-steroid;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		human metabolite;
mouse metabolite
cortodoxone
Cortodoxone: 17,21-Dihydroxypregn-4-ene-3,20-dione. A 17-hydroxycorticosteroid with glucocorticoid and anti-inflammatory activities.. 11-deoxycortisol : A deoxycortisol that is cortisol in which the hydroxy group at position 11 has been replaced by a hydrogen.		2.0110deoxycortisol;
glucocorticoid;
primary alpha-hydroxy ketone;
tertiary alpha-hydroxy ketone		human metabolite;
mouse metabolite
lithium
Lithium: An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.		2.1310alkali metal atom
17-ketosteroids
17-Ketosteroids: Steroids that contain a ketone group at position 17.. 17-oxo steroid : Any oxo steroid carrying the oxo group at position 17.		1.9410
androst-16-en-3-one
androst-16-en-3-one: boar taint steroid; RN given refers to (5alpha)-isomer. 5alpha-androst-16-en-3-one : An androstanoid that is 5alpha-androst-16-ene substituted by an oxo group at position 3. It is a steroid pheromone found in high concentrations in the saliva of male pigs,.		3.07503-oxo steroid;
androstanoid		mammalian metabolite;
pheromone
androstane
androstane: RN given refers to cpd without isomeric designation		1.9910steroid fundamental parent
ConditionIndicatedRelationship StrengthStudiesTrials
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.0410