Compounds > ancistroealaine a
Page last updated: 2024-11-12

ancistroealaine a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

ancistroealaine A: isolated from Ancistrocladus ealaensis; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ancistrotanzanine B : An isoquinoline alkaloid that is (3S)-6,8-dimethoxy-1,3-dimethyl-3,4-dihydroisoquinoline substituted by a 4,5-dimethoxy-7-methylnaphthalen-1-yl group at position 5. It is isolated from the leaves of Ancistrocladus tanzaniensis and exhibits antiplasmodial, antileishmanial and antitrypanocidal activities. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

FloraRankFlora DefinitionFamilyFamily Definition
Ancistrocladusgenus[no description available]Ancistrocladaceae[no description available]
Ancistrocladus tanzaniensisspecies[no description available]Ancistrocladaceae[no description available]

Cross-References

ID SourceID
PubMed CID10002166
CHEMBL ID390586
CHEBI ID65407
MeSH IDM0376531

Synonyms (6)

Synonym
ancistroealaine a
chebi:65407 ,
CHEMBL390586
ancistrotanzanine b
(3s)-5-(4,5-dimethoxy-7-methylnaphthalen-1-yl)-6,8-dimethoxy-1,3-dimethyl-3,4-dihydroisoquinoline
Q27133851
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (4)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
antileishmanial agentAn antiprotozoal drug used to treat or prevent infections caused by protozoan parasites that belong to the genus Leishmania.
antiplasmodial drugAn antiparasitic drug which is effective against Apicomplexan parasites in the genus Plasmodium. The genus contains over 200 species and includes those responsible for malaria.
trypanocidal drugA drug used to treat or prevent infections caused by protozoal organisms belonging to the suborder Trypanosomatida.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (6)

ClassDescription
aromatic etherAny ether in which the oxygen is attached to at least one aryl substituent.
isoquinoline alkaloidAny alkaloid that has a structure based on an isoquinoline nucleus. They are derived from the amino acids like tyrosine and phenylalanine.
methoxynaphthaleneAny alkyloxynaphthalene bearing one or more methoxy substituents.
methylnaphthalenesAny naphthalene carrying one or more methyl substituents.
biarylAn organic aromatic compound whose structure contains two aromatic rings or ring systems, joined to each other by a single bond.
isoquinolinesA class of organic heteropolycyclic compound consisting of isoquinoline and its substitution derivatives.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (21)

Assay IDTitleYearJournalArticle
AID356386Antimalarial activity against Plasmodium falciparum K12003Journal of natural products, Sep, Volume: 66, Issue:9
Ancistrotanzanine A, the first 5,3'-coupled naphthylisoquinoline alkaloid, and two further, 5,8'-linked related compounds from the newly described species Ancistrocladus tanzaniensis.
AID378202Antileishmanial activity against Leishmania donovani MHOM-ET-67/L82 amastigotes in mouse peritoneal macrophages2000Journal of natural products, Nov, Volume: 63, Issue:11
Ancistroealaines A and B, two new bioactive naphthylisoquinolines, and related naphthoic acids from Ancistrocladus ealaensis.
AID401528Antileishmanial activity against Leishmania donovani2004Journal of natural products, May, Volume: 67, Issue:5
Ancistrotanzanine C and related 5,1'- and 7,3'-coupled naphthylisoquinoline alkaloids from Ancistrocladus tanzaniensis.
AID378203Cytotoxicity against mouse peritoneal macrophages2000Journal of natural products, Nov, Volume: 63, Issue:11
Ancistroealaines A and B, two new bioactive naphthylisoquinolines, and related naphthoic acids from Ancistrocladus ealaensis.
AID377918Antiplasmodial activity against Plasmodium falciparum NF54 in human erythrocytes by [3H]hypoxanthine uptake2000Journal of natural products, Nov, Volume: 63, Issue:11
Ancistroealaines A and B, two new bioactive naphthylisoquinolines, and related naphthoic acids from Ancistrocladus ealaensis.
AID378200Cytotoxicity against rat L6 cells after 4 days2000Journal of natural products, Nov, Volume: 63, Issue:11
Ancistroealaines A and B, two new bioactive naphthylisoquinolines, and related naphthoic acids from Ancistrocladus ealaensis.
AID356390Antileishmanial activity against Leishmania donovani2003Journal of natural products, Sep, Volume: 66, Issue:9
Ancistrotanzanine A, the first 5,3'-coupled naphthylisoquinoline alkaloid, and two further, 5,8'-linked related compounds from the newly described species Ancistrocladus tanzaniensis.
AID1693983Cytotoxicity against human HeLa cells assessed as decrease in cell viability measured after 72 hrs by WST-8 assay2021Bioorganic & medicinal chemistry, 01-15, Volume: 30Ancistrobrevidines A-C and related naphthylisoquinoline alkaloids with cytotoxic activities against HeLa and pancreatic cancer cells, from the liana Ancistrocladus abbreviatus.
AID1693984Anti-austerity activity against nutrient-deprived human PANC-1 cells assessed as cell death incubated for 24 hrs by WST-8 assay2021Bioorganic & medicinal chemistry, 01-15, Volume: 30Ancistrobrevidines A-C and related naphthylisoquinoline alkaloids with cytotoxic activities against HeLa and pancreatic cancer cells, from the liana Ancistrocladus abbreviatus.
AID356389Antitrypanosomal activity against Trypanosoma brucei rhodesiense2003Journal of natural products, Sep, Volume: 66, Issue:9
Ancistrotanzanine A, the first 5,3'-coupled naphthylisoquinoline alkaloid, and two further, 5,8'-linked related compounds from the newly described species Ancistrocladus tanzaniensis.
AID356388Antitrypanosomal activity against Trypanosoma cruzi2003Journal of natural products, Sep, Volume: 66, Issue:9
Ancistrotanzanine A, the first 5,3'-coupled naphthylisoquinoline alkaloid, and two further, 5,8'-linked related compounds from the newly described species Ancistrocladus tanzaniensis.
AID278846Cytotoxicity against cloned virulent Leishmania major promastigotes MHOM/IL/81/FE/BN1 after 48 hrs2007Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1
Activities of naphthylisoquinoline alkaloids and synthetic analogs against Leishmania major.
AID356391Cytotoxicity against rat L6 cells2003Journal of natural products, Sep, Volume: 66, Issue:9
Ancistrotanzanine A, the first 5,3'-coupled naphthylisoquinoline alkaloid, and two further, 5,8'-linked related compounds from the newly described species Ancistrocladus tanzaniensis.
AID378201Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 by Alamar blue assay2000Journal of natural products, Nov, Volume: 63, Issue:11
Ancistroealaines A and B, two new bioactive naphthylisoquinolines, and related naphthoic acids from Ancistrocladus ealaensis.
AID377917Antiplasmodial activity against Plasmodium falciparum K1 in human erythrocytes by [3H]hypoxanthine uptake2000Journal of natural products, Nov, Volume: 63, Issue:11
Ancistroealaines A and B, two new bioactive naphthylisoquinolines, and related naphthoic acids from Ancistrocladus ealaensis.
AID389016Antileishmanial activity against Leishmania donovani LD-1S/MHOM/SD/00-strain 1S amastigotes2008Journal of natural products, Dec, Volume: 71, Issue:12
Antileishmanial constituents of the Panamanian endophytic fungus Edenia sp.
AID278852Decrease of infection rate in BALB/c mouse peritoneal macrophages infected with Leishmania major after 48 h incubation2007Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1
Activities of naphthylisoquinoline alkaloids and synthetic analogs against Leishmania major.
AID278848Cytotoxicity index, IC50 for J774.1 macrophages over IC50 for Leishmania major promastigotes2007Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1
Activities of naphthylisoquinoline alkaloids and synthetic analogs against Leishmania major.
AID278847Cytotoxicity against J774.1 macrophages after 48 hrs2007Antimicrobial agents and chemotherapy, Jan, Volume: 51, Issue:1
Activities of naphthylisoquinoline alkaloids and synthetic analogs against Leishmania major.
AID356387Antimalarial activity against Plasmodium falciparum 3D72003Journal of natural products, Sep, Volume: 66, Issue:9
Ancistrotanzanine A, the first 5,3'-coupled naphthylisoquinoline alkaloid, and two further, 5,8'-linked related compounds from the newly described species Ancistrocladus tanzaniensis.
AID378199Antitrypanosomal activity against galactosidase gene containing Trypanosoma cruzi Tulahuen C2C4 trypomastigotes in rat L6 cells after 4 days2000Journal of natural products, Nov, Volume: 63, Issue:11
Ancistroealaines A and B, two new bioactive naphthylisoquinolines, and related naphthoic acids from Ancistrocladus ealaensis.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (83.33)29.6817
2010's0 (0.00)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.87 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.82 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.87)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.9340aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
fluorouracil
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.		2.3110nucleobase analogue;
organofluorine compound		antimetabolite;
antineoplastic agent;
environmental contaminant;
immunosuppressive agent;
radiosensitizing agent;
xenobiotic
miltefosine
miltefosine: hexadecyl phosphocholine derivative of cisplatin; did not substantially activate HIV long terminal repeat; less toxic than cisplatin. miltefosine : A phospholipid that is the hexadecyl monoester of phosphocholine.		2.4220phosphocholines;
phospholipid		anti-inflammatory agent;
anticoronaviral agent;
antifungal agent;
antineoplastic agent;
antiprotozoal drug;
apoptosis inducer;
immunomodulator;
protein kinase inhibitor
melarsoprol
Melarsoprol: Arsenical used in trypanosomiases. It may cause fatal encephalopathy and other undesirable side effects.		2.730triazines
benzonidazole
benzonidazole: used in treatment of Chagas' disease. benznidazole : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease.		2.730C-nitro compound;
imidazoles;
monocarboxylic acid amide		antiprotozoal drug
arctigenin
arctigenin: precursor to catechols; in many plants		2.3110lignan
ancistrocladidine
ancistrocladidine: RN given for unspecified stereoisomer; structure in first source		2.4320
dioncophylline a
dioncophylline A: derived from the tropical vine Triphyophyllum peltatum; structure given in first source. dioncophylline A : An isoquinoline alkaloid that is the biaryl resulting from substitution of the hydrogen at the 7-position of (1R,3R)-1,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-8-ol by a 4,5-dimethoxy-2-methylnaphthalen-1-yl group. It is a naphthylisoquinoline alkaloid isolated from the roots and stem barks of Triphyophyllum peltatum and exhibits antifungal, antimalarial, antineoplastic and molluscicidal activites.		2.0310biaryl;
isoquinoline alkaloid;
isoquinolines;
methoxynaphthalene;
methylnaphthalenes;
naphthalenes		antifungal agent;
antimalarial;
metabolite;
molluscicide
dioncophylline c
dioncophylline C: structure given in first source. dioncophylline C : An isoquinoline alkaloid that is the biaryl resulting from substitution of the hydrogen at the 5-position of (1R,3R)-1,3-dimethyl-1,2,3,4-tetrahydroisoquinolin-8-ol by a 5-hydroxy-4-methoxy-2-methylnaphthalen-1-yl group. It is a naphthylisoquinoline alkaloid isolated from the roots and stem barks of Triphyophyllum peltatum and exhibits antimalarial activity.		2.0310aromatic ether;
biaryl;
isoquinoline alkaloid;
isoquinolines;
methoxynaphthalene;
methylnaphthalenes;
naphthols		antimalarial;
antiplasmodial drug;
metabolite
amphotericin b
Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.		2.0410antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite
nifurtimox
Nifurtimox: A nitrofuran thiazine that has been used against TRYPANOSOMIASIS.		2.0410nitrofuran antibiotic
palmarumycin cp2
palmarumycin CP2: a type of spirobisnaphthalene, which contain two naphthalene-derived c10 units bridged through a spiroketal linkage with two oxygen bridges; structure in first source		2.0410
ancistrocladinium b
ancistrocladinium B: structure in first source		2.4420
ConditionIndicatedRelationship StrengthStudiesTrials
Leishmania Infection
[description not available]		02.0310
Leishmaniasis
A disease caused by any of a number of species of protozoa in the genus LEISHMANIA. There are four major clinical types of this infection: cutaneous (Old and New World) (LEISHMANIASIS, CUTANEOUS), diffuse cutaneous (LEISHMANIASIS, DIFFUSE CUTANEOUS), mucocutaneous (LEISHMANIASIS, MUCOCUTANEOUS), and visceral (LEISHMANIASIS, VISCERAL).		02.0310