Page last updated: 2024-12-10
alpha-2'-deoxythioguanosine
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
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Research Growth
Market Indicators
Description
alpha-2'-deoxythioguanosine: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
ID Source | ID |
---|---|
PubMed CID | 3005835 |
CHEMBL ID | 3230221 |
SCHEMBL ID | 9222786 |
MeSH ID | M0042528 |
Synonyms (18)
Synonym |
---|
2-amino-9-[(2s,4s,5r)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1h-purine-6-thione |
2133-81-5 |
alpha-tgdr |
2-amino-9-(2-deoxy-alpha-d-erythro-pentofuranosyl)-9h-purine-6-thiol |
alpha-2'-deoxy-6-thioguanosine |
alpha-thiodeoxyguanosine |
alpha-deoxythioguanosine |
thioguanine 9alphad-2'-deoxyriboside |
9h-purine-6(1h)-thione, 2-amino-9-(2-deoxy-alpha-d-erythro-pentofuranosyl)- |
alpha-2'-deoxythioguanosine |
6h-purine-6-thione, 2-amino-9-(2-deoxy-alpha-d-erythro-pentofuranosyl)-1,9-dihydro- |
t-dguo |
CCG-35478 |
CHEMBL3230221 |
SCHEMBL9222786 |
2-amino-9-(2-deoxy-alpha-d-erythro-pentofuranosyl)-1,9-dihydro-6h-purine-6-thione |
2-amino-9-((2s,4s,5r)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3h-purine-6(9h)-thione |
DTXSID901139308 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (29)
Assay ID | Title | Year | Journal | Article |
---|---|---|---|---|
AID1133841 | Inhibition of DNA synthesis in mouse L1210 cells assessed as inhibition of tritiated thymidine incorporation into nucleic acids | 1977 | Journal of medicinal chemistry, Mar, Volume: 20, Issue:3 | Potential antitumor agents. Some sulfur-substituted derivatives of alpha- and beta-2'-deoxythioguanosine. |
AID1124751 | Stability in RPMI 1640 assessed as formation of thioguanine after 24 hrs in presence of 10% dialyzed horse serum | 1979 | Journal of medicinal chemistry, May, Volume: 22, Issue:5 | Improved antitumor effects in 3'-branched homologues of 2'-deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose. |
AID1124754 | Stability in human WIL2 cells assessed as formation of thioguanine | 1979 | Journal of medicinal chemistry, May, Volume: 22, Issue:5 | Improved antitumor effects in 3'-branched homologues of 2'-deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose. |
AID1133835 | Antitumor activity in mouse L1210 cells allografted in mouse assessed as increase in survival time at optimal dose administered qd on days 1 to 5 of challenge relative to control | 1977 | Journal of medicinal chemistry, Mar, Volume: 20, Issue:3 | Potential antitumor agents. Some sulfur-substituted derivatives of alpha- and beta-2'-deoxythioguanosine. |
AID1124755 | Antiproliferative activity against human WIL2 cells assessed as decrease in cell number at 100 to 300 uM measured every 24 hrs by electronic particle counting analysis in presence of 10% dialyzed horse serum | 1979 | Journal of medicinal chemistry, May, Volume: 22, Issue:5 | Improved antitumor effects in 3'-branched homologues of 2'-deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose. |
AID1133840 | Antitumor activity in mouse P388 cells allografted in mouse assessed as increase in survival time at optimal dose administered qd on days 1 to 9 of challenge relative to control | 1977 | Journal of medicinal chemistry, Mar, Volume: 20, Issue:3 | Potential antitumor agents. Some sulfur-substituted derivatives of alpha- and beta-2'-deoxythioguanosine. |
AID1124752 | Stability in RPMI 1640 after 24 hrs in presence of 10% fetal calf serum | 1979 | Journal of medicinal chemistry, May, Volume: 22, Issue:5 | Improved antitumor effects in 3'-branched homologues of 2'-deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose. |
AID1124740 | Antiproliferative activity against human WIL2 cells assessed as cell number per ml at 200 uM measured immediately post compound treatment by electronic particle counting analysis in presence of 10% fetal calf serum (Rvb = 1 x 10'-5/ml) | 1979 | Journal of medicinal chemistry, May, Volume: 22, Issue:5 | Improved antitumor effects in 3'-branched homologues of 2'-deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose. |
AID1124744 | Antiproliferative activity against human WIL2 cells assessed as cell number per ml at 300 uM measured at 23.5 hrs by electronic particle counting analysis in presence of 10% fetal calf serum (Rvb = 3.4 x 10'-5/ml) | 1979 | Journal of medicinal chemistry, May, Volume: 22, Issue:5 | Improved antitumor effects in 3'-branched homologues of 2'-deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose. |
AID1133837 | Antitumor activity in mouse L1210 cells allografted in mouse assessed as increase in survival time at optimal dose administered qd on days 1 to 16 of challenge relative to control | 1977 | Journal of medicinal chemistry, Mar, Volume: 20, Issue:3 | Potential antitumor agents. Some sulfur-substituted derivatives of alpha- and beta-2'-deoxythioguanosine. |
AID1124741 | Antiproliferative activity against human WIL2 cells assessed as cell number per ml at 300 uM measured immediately post compound treatment by electronic particle counting analysis in presence of 10% fetal calf serum (Rvb = 1 x 10'-5/ml) | 1979 | Journal of medicinal chemistry, May, Volume: 22, Issue:5 | Improved antitumor effects in 3'-branched homologues of 2'-deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose. |
AID1133842 | Inhibition of RNA synthesis in mouse L1210 cells assessed as inhibition of tritiated uridine incorporation into nucleic acids | 1977 | Journal of medicinal chemistry, Mar, Volume: 20, Issue:3 | Potential antitumor agents. Some sulfur-substituted derivatives of alpha- and beta-2'-deoxythioguanosine. |
AID1124733 | Acid-insoluble DNA incorporation in mouse Mecca lymphosarcoma ascite tumor allografted in AKD2F1 mouse assessed as detection of [35S] in nucleoside at 2.6 umol after 4 hrs by scintillation counting analysis | 1979 | Journal of medicinal chemistry, May, Volume: 22, Issue:5 | Improved antitumor effects in 3'-branched homologues of 2'-deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose. |
AID1124732 | Acid-insoluble DNA incorporation in mouse Mecca lymphosarcoma ascite tumor allografted in AKD2F1 mouse assessed per mg of DNA at 2.6 umol, ip after 4 hrs by scintillation counting analysis | 1979 | Journal of medicinal chemistry, May, Volume: 22, Issue:5 | Improved antitumor effects in 3'-branched homologues of 2'-deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose. |
AID1124743 | Antiproliferative activity against human WIL2 cells assessed as cell number per ml at 200 uM measured at 23.5 hrs by electronic particle counting analysis in presence of 10% fetal calf serum (Rvb = 3.4 x 10'-5/ml) | 1979 | Journal of medicinal chemistry, May, Volume: 22, Issue:5 | Improved antitumor effects in 3'-branched homologues of 2'-deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose. |
AID1124735 | Acid-soluble DNA incorporation in mouse Mecca lymphosarcoma ascite tumor allografted in AKD2F1 mouse assessed as detection of [35S] in nucleoside per mg of DNA at 2.6 umol after 4 hrs by scintillation counting analysis | 1979 | Journal of medicinal chemistry, May, Volume: 22, Issue:5 | Improved antitumor effects in 3'-branched homologues of 2'-deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose. |
AID1124753 | Stability in RPMI 1640 after 20 mins in presence of 10% fetal calf serum | 1979 | Journal of medicinal chemistry, May, Volume: 22, Issue:5 | Improved antitumor effects in 3'-branched homologues of 2'-deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose. |
AID1124738 | Acid-soluble DNA incorporation in mouse Mecca lymphosarcoma ascite tumor allografted in AKD2F1 mouse assessed as snake venome 5'-nucleotidase-mediated nucleotide hydrolysis at 2.6 umol after 2 hrs | 1979 | Journal of medicinal chemistry, May, Volume: 22, Issue:5 | Improved antitumor effects in 3'-branched homologues of 2'-deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose. |
AID1124746 | Antiproliferative activity against human WIL2 cells assessed as cell number per ml at 200 uM measured at 47.5 hrs by electronic particle counting analysis in presence of 10% fetal calf serum (Rvb = 10.7 x 10'-5/ml) | 1979 | Journal of medicinal chemistry, May, Volume: 22, Issue:5 | Improved antitumor effects in 3'-branched homologues of 2'-deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose. |
AID1124739 | Antiproliferative activity against human WIL2 cells assessed as cell number per ml at 100 uM measured immediately post compound treatment by electronic particle counting analysis in presence of 10% fetal calf serum (Rvb = 1 x 10'-5/ml) | 1979 | Journal of medicinal chemistry, May, Volume: 22, Issue:5 | Improved antitumor effects in 3'-branched homologues of 2'-deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose. |
AID1124745 | Antiproliferative activity against human WIL2 cells assessed as cell number per ml at 100 uM measured at 47.5 hrs by electronic particle counting analysis in presence of 10% fetal calf serum (Rvb = 10.7 x 10'-5/ml) | 1979 | Journal of medicinal chemistry, May, Volume: 22, Issue:5 | Improved antitumor effects in 3'-branched homologues of 2'-deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose. |
AID1124742 | Antiproliferative activity against human WIL2 cells assessed as cell number per ml at 100 uM measured at 23.5 hrs by electronic particle counting analysis in presence of 10% fetal calf serum (Rvb = 3.4 x 10'-5/ml) | 1979 | Journal of medicinal chemistry, May, Volume: 22, Issue:5 | Improved antitumor effects in 3'-branched homologues of 2'-deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose. |
AID1124747 | Antiproliferative activity against human WIL2 cells assessed as cell number per ml at 300 uM measured at 47.5 hrs by electronic particle counting analysis in presence of 10% fetal calf serum (Rvb = 10.7 x 10'-5/ml) | 1979 | Journal of medicinal chemistry, May, Volume: 22, Issue:5 | Improved antitumor effects in 3'-branched homologues of 2'-deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose. |
AID1124737 | Acid-soluble DNA incorporation in mouse Mecca lymphosarcoma ascite tumor allografted in AKD2F1 mouse assessed as wheat germ 3'-nucleotidase-mediated nucleotide hydrolysis at 2.6 umol after 1 hr | 1979 | Journal of medicinal chemistry, May, Volume: 22, Issue:5 | Improved antitumor effects in 3'-branched homologues of 2'-deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose. |
AID1124749 | Antiproliferative activity against human WIL2 cells assessed as cell number per ml at 200 uM measured at 71 hrs by electronic particle counting analysis in presence of 10% fetal calf serum (Rvb = 16 x 10'-5/ml) | 1979 | Journal of medicinal chemistry, May, Volume: 22, Issue:5 | Improved antitumor effects in 3'-branched homologues of 2'-deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose. |
AID1124736 | Acid-soluble DNA incorporation in mouse Mecca lymphosarcoma ascite tumor allografted in AKD2F1 mouse assessed as detection of [35S] in nucleotide per mg of DNA at 2.6 umol after 4 hrs by scintillation counting analysis | 1979 | Journal of medicinal chemistry, May, Volume: 22, Issue:5 | Improved antitumor effects in 3'-branched homologues of 2'-deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose. |
AID1124748 | Antiproliferative activity against human WIL2 cells assessed as cell number per ml at 100 uM measured at 71 hrs by electronic particle counting analysis in presence of 10% fetal calf serum (Rvb = 16 x 10'-5/ml) | 1979 | Journal of medicinal chemistry, May, Volume: 22, Issue:5 | Improved antitumor effects in 3'-branched homologues of 2'-deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose. |
AID1124734 | Acid-insoluble DNA incorporation in mouse Mecca lymphosarcoma ascite tumor allografted in AKD2F1 mouse assessed as detection of [35S] in nucleotide at 2.6 umol after 4 hrs by scintillation counting analysis | 1979 | Journal of medicinal chemistry, May, Volume: 22, Issue:5 | Improved antitumor effects in 3'-branched homologues of 2'-deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose. |
AID1124750 | Antiproliferative activity against human WIL2 cells assessed as cell number per ml at 300 uM measured at 71 hrs by electronic particle counting analysis in presence of 10% fetal calf serum (Rvb = 16 x 10'-5/ml) | 1979 | Journal of medicinal chemistry, May, Volume: 22, Issue:5 | Improved antitumor effects in 3'-branched homologues of 2'-deoxythioguanosine. Synthesis and evaluation of thioguanine nucleosides of 2,3-dideoxy-3-(hydroxymethyl)-D-erythro-pentofuranose. |
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Research
Studies (20)
Timeframe | Studies, This Drug (%) | All Drugs % |
---|---|---|
pre-1990 | 3 (15.00) | 18.7374 |
1990's | 2 (10.00) | 18.2507 |
2000's | 2 (10.00) | 29.6817 |
2010's | 7 (35.00) | 24.3611 |
2020's | 6 (30.00) | 2.80 |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |
Market Indicators
Research Demand Index: 12.15
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (12.15) All Compounds (24.57) |
Study Types
Publication Type | This drug (%) | All Drugs (%) |
---|---|---|
Trials | 0 (0.00%) | 5.53% |
Reviews | 0 (0.00%) | 6.00% |
Case Studies | 0 (0.00%) | 4.05% |
Observational | 0 (0.00%) | 0.25% |
Other | 20 (100.00%) | 84.16% |
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] |