Page last updated: 2024-11-13

alloferon

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Alloferon: immunomodulator; active ingredient of the antiviral agent allokine-alpha [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID25088392
MeSH IDM0498367

Synonyms (1)

Synonym
alloferon

Research Excerpts

Overview

Alloferon-1 is an insect polypeptide that has anti-inflammatory, antitumor and antiviral activity. Alloferon is a 13-amino acid peptide isolated from the bacteria-challenged larvae of the blow fly Calliphora vicina.

ExcerptReferenceRelevance
"Alloferon-1 is an insect polypeptide that has anti-inflammatory, antitumor and antiviral activity. "( Alloferon-1 ameliorates estrogen deficiency-induced osteoporosis through dampening the NLRP3/caspase-1/IL-1β/IL-18 signaling pathway.
Chen, Z; Qiao, S; Tzeng, CM; Zhang, X; Zhao, Y, 2023
)
3.8
"Alloferon is a novel immunomodulatory peptide originally isolated from infected insects. "( The effect of alloferon on the enhancement of NK cell cytotoxicity against cancer via the up-regulation of perforin/granzyme B secretion.
Bae, S; Hwang, YI; Kang, JS; Kim, H; Kim, HR; Kim, Y; Lee, DS; Lee, WJ; Oh, K, 2013
)
2.19
"Alloferons are a group of naturally occurring peptides primarily isolated from insects and capable of stimulating mouse and human NK cell cytotoxicity towards cancer cells. "( Anti-tumor activity of a peptide combining patterns of insect alloferons and mammalian immunoglobulins in naïve and tumor antigen vaccinated mice.
Chernysh, S; Kozuharova, I, 2013
)
2.07
"Alloferon 1 is an insect-derived peptide with potent antimicrobial and antitumor activity. "( Effect of alloferon 1 on central nervous system in rats.
Kuczer, M; Oleś, M; Oleś, P; Plech, A; Rykaczewska-Czerwińska, M,
)
1.98
"Alloferons are a group of antiviral and anti-tumor peptides primarily isolated from insects and stimulating cytotoxic activity of natural killer cells in mammals including mice and humans. "( Anti-tumor activity of immunomodulatory peptide alloferon-1 in mouse tumor transplantation model.
Chernysh, S; Irina, A; Irina, K, 2012
)
2.08
"Alloferon is a 13-amino acid peptide isolated from the bacteria-challenged larvae of the blow fly Calliphora vicina. "( Activation of NF-kappaB by alloferon through down-regulation of antioxidant proteins and IkappaBalpha.
Anikin, V; Chernysh, S; Hong, SH; Jeon, H; Lee, C; Ryu, MJ; Yu, MH; Yu, YG, 2008
)
2.09

Effects

ExcerptReferenceRelevance
"Alloferon-1 have been proposed as an effective peptide to enhance antitumoral immunity, antiviral defense and anti-inflammatory activity. "( Alloferon-1 ameliorates acute inflammatory responses in λ-carrageenan-induced paw edema in mice.
Qiao, S; Retyunskiy, V; Tzeng, CM; Zhang, X; Zhao, Y, 2022
)
3.61
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (28)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (10.71)29.6817
2010's22 (78.57)24.3611
2020's3 (10.71)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 36.17

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index36.17 (24.57)
Research Supply Index3.56 (2.92)
Research Growth Index5.12 (4.65)
Search Engine Demand Index45.89 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (36.17)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials1 (3.03%)5.53%
Reviews1 (3.03%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other31 (93.94%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]