Compounds > aglucovancomycin b
Page last updated: 2024-12-08

aglucovancomycin b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

aglucovancomycin B: degradation product of vancomycin B; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

vancomycin aglycone : A peptide antibiotic that is vancomycin lacking the disaccharide moiety. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID445835
CHEMBL ID439343
CHEBI ID47724
SCHEMBL ID18089766
MeSH IDM0413596

Synonyms (12)

Synonym
(2-amino-2-oxo-ethyl)-dichloro-hexahydroxy-[[(2r)-4-methyl-2-(methylamino)pentanoyl]amino]-pentaoxo-[?]carboxylic acid
vancomycin aglycon
aglucovancomycin b
82198-76-3
balhimycin aglycon
CHEMBL439343
chebi:47724 ,
vancomycin aglycone
C20719
SCHEMBL18089766
JHIKFOISFAQTJQ-YZANBJIASA-N
Q27120784
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
metaboliteAny intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (5)

ClassDescription
peptide zwitterionZwitterionic form of any peptide where, in general, the amino terminus is positively charged and the carboxy terminus is negatively charged.
peptide antibioticA chemically diverse class of peptides that exhibit antimicrobial properties.
heterodetic cyclic peptideA heterodetic cyclic peptide is a peptide consisting only of amino-acid residues, but in which the linkages forming the ring are not solely peptide bonds; one or more is an isopeptide, disulfide, ester, or other bond.
cyclic etherAny ether in which the oxygen atom forms part of a ring.
polyphenolMembers of the class of phenols that contain 2 or more benzene rings each of which is substituted by at least one hydroxy group.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (25)

Assay IDTitleYearJournalArticle
AID1262241Antibacterial activity against vancomycin-sensitive Enterococcus faecium after 24 hrs by broth micro dilution assay2015Bioorganic & medicinal chemistry letters, Dec-01, Volume: 25, Issue:23
Lipophilic vancomycin aglycon dimer with high activity against vancomycin-resistant bacteria.
AID764932Binding affinity to N,N'-Ac2-L-Lys-D-Ala-D-Phe model of cell wall ligand by UV-difference assay2013Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17
Investigation into the functional impact of the vancomycin C-ring aryl chloride.
AID370461Antimicrobial activity against vancomycin-sensitive Staphylococcus aureus ATCC 25923 after 24 hrs by microtiter plate based antimicrobial assay2009Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
Synthesis and evaluation of vancomycin aglycon analogues that bear modifications in the N-terminal D-leucyl amino acid.
AID68248In vitro antibacterial activity against vancomycin resistant Enterococcus faecium2002Bioorganic & medicinal chemistry letters, May-06, Volume: 12, Issue:9
Synthesis and evaluation of vancomycin and vancomycin aglycon analogues that bear modifications in the residue 3 asparagine.
AID1262243Antibacterial activity against vancomycin-resistant Enterococcus faecium ATCC 51559 after 24 hrs by broth micro dilution assay2015Bioorganic & medicinal chemistry letters, Dec-01, Volume: 25, Issue:23
Lipophilic vancomycin aglycon dimer with high activity against vancomycin-resistant bacteria.
AID739992Antimicrobial activity against VanA vancomycin-resistant Enterococcus faecalis BM41662013Journal of medicinal chemistry, May-23, Volume: 56, Issue:10
Probing the role of the vancomycin e-ring aryl chloride: selective divergent synthesis and evaluation of alternatively substituted E-ring analogues.
AID1262240Antibacterial activity against methicillin-resistant Staphylococcus aureus ATCC 33591 after 24 hrs by broth micro dilution assay2015Bioorganic & medicinal chemistry letters, Dec-01, Volume: 25, Issue:23
Lipophilic vancomycin aglycon dimer with high activity against vancomycin-resistant bacteria.
AID206443In vitro antibacterial activity against methicillin sensitive Staphylococcus aureus (ATCC 25923)2002Bioorganic & medicinal chemistry letters, May-06, Volume: 12, Issue:9
Synthesis and evaluation of vancomycin and vancomycin aglycon analogues that bear modifications in the residue 3 asparagine.
AID739991Antimicrobial activity against Staphylococcus aureus ATCC 259232013Journal of medicinal chemistry, May-23, Volume: 56, Issue:10
Probing the role of the vancomycin e-ring aryl chloride: selective divergent synthesis and evaluation of alternatively substituted E-ring analogues.
AID764933Binding affinity to N,N'-Ac2-L-Lys-D-Ala-D-Ala model of cell wall ligand by UV-difference assay2013Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17
Investigation into the functional impact of the vancomycin C-ring aryl chloride.
AID1262239Antibacterial activity against methicillin-sensitive Staphylococcus aureus after 24 hrs by broth micro dilution assay2015Bioorganic & medicinal chemistry letters, Dec-01, Volume: 25, Issue:23
Lipophilic vancomycin aglycon dimer with high activity against vancomycin-resistant bacteria.
AID67382In vitro antibacterial activity against vancomycin resistant Enterococcus faecalis (VanB, ATCC 51299)2002Bioorganic & medicinal chemistry letters, May-06, Volume: 12, Issue:9
Synthesis and evaluation of vancomycin and vancomycin aglycon analogues that bear modifications in the residue 3 asparagine.
AID739990Antimicrobial activity against VanB vancomycin-resistant Enterococcus faecalis ATCC 51299 after 24 hrs by microtiter plate assay2013Journal of medicinal chemistry, May-23, Volume: 56, Issue:10
Probing the role of the vancomycin e-ring aryl chloride: selective divergent synthesis and evaluation of alternatively substituted E-ring analogues.
AID739994Antimicrobial activity against vancomycin-sensitive Staphylococcus aureus ATCC 25923 after 24 hrs by microtiter plate assay2013Journal of medicinal chemistry, May-23, Volume: 56, Issue:10
Probing the role of the vancomycin e-ring aryl chloride: selective divergent synthesis and evaluation of alternatively substituted E-ring analogues.
AID68240In vitro antibacterial activity against Enterococcus faecium (ATCC 35667)2002Bioorganic & medicinal chemistry letters, May-06, Volume: 12, Issue:9
Synthesis and evaluation of vancomycin and vancomycin aglycon analogues that bear modifications in the residue 3 asparagine.
AID67253In vitro antibacterial activity against vancomycin resistant Enterococcus faecalis (VanA, BM4166)2002Bioorganic & medicinal chemistry letters, May-06, Volume: 12, Issue:9
Synthesis and evaluation of vancomycin and vancomycin aglycon analogues that bear modifications in the residue 3 asparagine.
AID370462Antimicrobial activity against vancomycin-resistant Enterococcus faecalis BM4166 after 24 hrs by microtiter plate based antimicrobial assay2009Journal of medicinal chemistry, Mar-12, Volume: 52, Issue:5
Synthesis and evaluation of vancomycin aglycon analogues that bear modifications in the N-terminal D-leucyl amino acid.
AID764935Antimicrobial activity against vancomycin-sensitive Staphylococcus aureus ATCC 25923 after 24 hrs2013Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17
Investigation into the functional impact of the vancomycin C-ring aryl chloride.
AID764931Binding affinity to N,N'-Ac2-L-Lys-D-Ala-Gly model of cell wall ligand by UV-difference assay2013Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17
Investigation into the functional impact of the vancomycin C-ring aryl chloride.
AID227930Binding constant for the formation of a 1:1 antibioticpeptide complex with the tripeptide N,N'-diacetyl-l-Lys-d-Ala-d-Lac2002Bioorganic & medicinal chemistry letters, May-06, Volume: 12, Issue:9
Synthesis and evaluation of vancomycin and vancomycin aglycon analogues that bear modifications in the residue 3 asparagine.
AID739989Binding affinity to N,N'-Ac2-L-Lys-D-Ala-D-Ala (unknown origin)2013Journal of medicinal chemistry, May-23, Volume: 56, Issue:10
Probing the role of the vancomycin e-ring aryl chloride: selective divergent synthesis and evaluation of alternatively substituted E-ring analogues.
AID764934Binding affinity to N,N'-Ac2-L-Lys-D-Ala-D-Ser model of cell wall ligand by UV-difference assay2013Bioorganic & medicinal chemistry letters, Sep-01, Volume: 23, Issue:17
Investigation into the functional impact of the vancomycin C-ring aryl chloride.
AID227929Binding constant for the formation of a 1:1 antibioticpeptide complex with the tripeptide N,N'-diacetyl-l-Lys-d-Ala-d-Ala; 2.3-3.92002Bioorganic & medicinal chemistry letters, May-06, Volume: 12, Issue:9
Synthesis and evaluation of vancomycin and vancomycin aglycon analogues that bear modifications in the residue 3 asparagine.
AID739993Antimicrobial activity against VanB vancomycin-resistant Enterococcus faecalis ATCC 512992013Journal of medicinal chemistry, May-23, Volume: 56, Issue:10
Probing the role of the vancomycin e-ring aryl chloride: selective divergent synthesis and evaluation of alternatively substituted E-ring analogues.
AID1262242Antibacterial activity against vancomycin-intermediate-resistant Staphylococcus aureus ATCC 33591 after 24 hrs by broth micro dilution assay2015Bioorganic & medicinal chemistry letters, Dec-01, Volume: 25, Issue:23
Lipophilic vancomycin aglycon dimer with high activity against vancomycin-resistant bacteria.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (50.00)29.6817
2010's3 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.56 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.51 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
cetyltrimethylammonium ion
Cetrimonium: Cetyltrimethylammonium compound whose salts and derivatives are used primarily as topical antiseptics.. cetyltrimethylammonium ion : A quaternary ammonium ion in which the substituents on nitrogen are one hexadecyl and three methyl groups.		210quaternary ammonium ion
tromethamine
Tromethamine: An organic amine proton acceptor. It is used in the synthesis of surface-active agents and pharmaceuticals; as an emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, as a biological buffer, and used as an alkalizer. (From Merck, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p1424)		210primary amino compound;
triol		buffer
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		3.1450glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
eremomycin aglycone
[no description available]		2.0810
teicoplanin aglycone
[no description available]		2.0810oligopeptide
ConditionIndicatedRelationship StrengthStudiesTrials
Infections, Staphylococcal
[description not available]		02.0810
Staphylococcal Infections
Infections with bacteria of the genus STAPHYLOCOCCUS.		02.0810