Page last updated: 2024-12-10

adhesamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

adhesamine: synthetic diaryldispirotripiperazine that targets selective cell-surface glycosaminoglycans,especially heparan sulfate, for increasing cell adhesion and growth; a useful reagent for culturing neuronal cells [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID2828084
MeSH IDM0546734

Synonyms (5)

Synonym
adhesamine
4-chloro-6-[12-(6-chloro-5-formyl-2-methylsulfanylpyrimidin-4-yl)-3,12-diaza-6,9-diazoniadispiro[5.2.59.26]hexadecan-3-yl]-2-methylsulfanylpyrimidine-5-carbaldehyde;dichloride
462605-73-8
CS-0088185
HY-122672

Research Excerpts

Overview

Adhesamine is an organic small molecule that promotes adhesion and growth of cultured human cells. It binds selectively to heparan sulfate on the cell surface.

ExcerptReferenceRelevance
"Adhesamine is an organic small molecule that promotes adhesion and growth of cultured human cells by binding selectively to heparan sulfate on the cell surface. "( Small-molecule-induced clustering of heparan sulfate promotes cell adhesion.
Frisco, HL; Gardiner, JM; Hansen, SU; Inoue, R; Jayson, GC; Kanaya, T; Kawazoe, Y; Kioka, N; Kusamori, K; Miller, GJ; Mizuhata, Y; Nishikawa, M; Park, SM; Sato, S; Sezaki, T; Suehara, T; Takakura, Y; Takemoto, N; Tokitoh, N; Ueda, K; Uesugi, M; Yamazoe, S, 2013
)
1.83
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (66.67)24.3611
2020's2 (33.33)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.11

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.11 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index5.06 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.11)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (33.33%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (66.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]