Adamantane diazirine is a photoaffinity labeling reagent that has been used to study protein-protein interactions. It is synthesized by the reaction of adamantane with diazomethane. Upon photolysis, adamantane diazirine generates a highly reactive carbene that can insert into C-H bonds, forming a covalent bond with the target protein. This allows for the identification of proteins that interact with the molecule of interest. Adamantane diazirine is particularly useful for studying membrane proteins due to its ability to cross cell membranes.'
adamantane diazirine: structure in second source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 64353 |
| SCHEMBL ID | 12339179 |
| MeSH ID | M0082003 |
| Synonym |
|---|
| adamantane diazirine |
| spiro[adamantane-2,3'-diazirine] |
| 41736-95-2 |
| spiro(adamantane-2,2'-diazirine) |
| spiro(3h-diazirine-3,2'-tricyclo(3.3.1.1(3,7))decane) |
| SCHEMBL12339179 |
| adamantane-2-spiro-3'-diazirine |
| spiro[diazirene-3,2'-tricyclo[3.3.1.1~3,7~]decane] |
| DTXSID00961940 |
| STARBLD0002461 |
| (1r,3r,5r,7r)-spiro[adamantane-2,2'-diazirine] |
| EN300-22882763 |
| AKOS040750127 |
Adamantane diazirine is a hydrophobic photoactivated probe that partitions into the cell membrane. It can be used to identify regions of proteins that are embedded within the membrane.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Adamantane diazirine is a hydrophobic photoactivated probe that partitions into the cell membrane and can be used to identify regions of proteins that are embedded within the membrane." | ( Identification of hydrophobic regions of the calcium-transport ATPase from sarcoplasmic reticulum after photochemical labeling with adamantane diazirine. Farley, RA, 1983) | 1.19 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 8 (88.89) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.98) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 9 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||