a 90720a profile

Cross-References

ID Source	ID
PubMed CID	448770
CHEMBL ID	403894
MeSH ID	M0284392

Synonyms (5)

Synonym
1TPS
a90720a
a-90720a
CHEMBL403894
[(2r)-3-[[(2r)-1-[[(2s,5s,8s,11r,12s,15s,18s,21r)-15-[3-(diaminomethylideneamino)propyl]-21-hydroxy-5-[(4-hydroxyphenyl)methyl]-4,11-dimethyl-2-(2-methylpropyl)-3,6,9,13,16,22-hexaoxo-8-propan-2-yl-10-oxa-1,4,7,14,17-pentazabicyclo[16.3.1]docosan-12-yl]am

Protein Targets (1)

Inhibition Measurements

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, Trypsin	Bos taurus (cattle)	IC50 (µMol)	0.0100	0.0100	0.0100	0.0100	AID977608
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay ID	Title	Year	Journal	Article
AID419326	Inhibition of chymotrypsin	2005	Journal of natural products, Jan, Volume: 68, Issue:1	Two new chymotrypsin inhibitors isolated from the Cyanobacterium Microcystis aeruginosa NIES-88.
AID319552	Inhibition of trypsin	2008	Journal of natural products, Jan, Volume: 71, Issue:1	Symplocamide A, a potent cytotoxin and chymotrypsin inhibitor from the marine Cyanobacterium Symploca sp.
AID319553	Inhibition of chymotrypsin	2008	Journal of natural products, Jan, Volume: 71, Issue:1	Symplocamide A, a potent cytotoxin and chymotrypsin inhibitor from the marine Cyanobacterium Symploca sp.
AID311020	Inhibition of trypsin	2007	Bioorganic & medicinal chemistry, Jul-01, Volume: 15, Issue:13	Resisting degradation by human elastase: commonality of design features shared by 'canonical' plant and bacterial macrocyclic protease inhibitor scaffolds.
AID419327	Inhibition of trypsin	2005	Journal of natural products, Jan, Volume: 68, Issue:1	Two new chymotrypsin inhibitors isolated from the Cyanobacterium Microcystis aeruginosa NIES-88.
AID490438	Inhibition of bovine trypsin	2010	Journal of natural products, May-28, Volume: 73, Issue:5	Multiple toxin production in the cyanobacterium microcystis: isolation of the toxic protease inhibitor cyanopeptolin 1020.
AID1811	Experimentally measured binding affinity data derived from PDB	1994	Chemistry & biology, Oct, Volume: 1, Issue:2	Atomic structure of the trypsin-A90720A complex: a unified approach to structure and function.
AID977608	Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB	1994	Chemistry & biology, Oct, Volume: 1, Issue:2	Atomic structure of the trypsin-A90720A complex: a unified approach to structure and function.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (20.00)	18.2507
2000's	3 (60.00)	29.6817
2010's	1 (20.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.03

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	13.03 (24.57)
Research Supply Index	1.79 (2.92)
Research Growth Index	4.82 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (13.03)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

a 90720a