Compounds > N-acetyl-alpha-D-galactosamine
Page last updated: 2024-12-07

N-acetyl-alpha-D-galactosamine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N-acetyl-alpha-D-galactosamine is a naturally occurring monosaccharide derivative that is found in various biological systems. It is a modified form of galactose, with an acetylated amino group attached to the C-2 position. N-acetyl-alpha-D-galactosamine plays important roles in various biological processes, including cell signaling, immune responses, and the synthesis of glycoproteins and glycolipids. The compound has been studied for its potential therapeutic applications, particularly in the treatment of certain types of cancer and inflammatory diseases. Its synthesis is often achieved through enzymatic methods, utilizing enzymes such as N-acetylgalactosaminyltransferases. The compound has been shown to exhibit anti-inflammatory effects, inhibit tumor cell growth, and modulate immune responses.'

N-acetyl-alpha-D-galactosamine : An N-acetyl-D-galactosamine having alpha-configuration at the anomeric centre. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID84265
CHEMBL ID1230702
CHEBI ID40356
SCHEMBL ID262932
SCHEMBL ID21196403

Synonyms (151)

Synonym
CHEBI:40356 ,
2-(acetylamino)-2-deoxy-alpha-d-galactopyranose
CHEMBL1230702
n-acetyl-2-deoxy-2-amino-galactose
a2g ,
2-acetamido-2-deoxy-alpha-d-galactopyranose
tn saccharide component
1AX0 ,
alpha-galnac
tn antigen saccharide component
galnac-alpha
tn saccharide
tn antigen saccharide
n-acetyl-alpha-d-galactosamine
alpha-galpnac
DB03567
alpha-n-acetyl-d-galactosamine
alpha-d-galactopyranose, 2-(acetylamino)-2-deoxy-
n-[(2s,3r,4r,5r,6r)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
unii-00c01apn10
00c01apn10 ,
EPITOPE ID:141584
.alpha.-d-galactopyranose, 2-(acetylamino)-2-deoxy-
SCHEMBL262932
2VMC
3N35
n-acetyl-a-d-glucosamine
2-acetamido-2-deoxy-.alpha.-d-galactose
.alpha.-n-acetyl-d-galactosamine
2-acetamido-2-deoxy-.alpha.-d-galactopyranose
2-deoxy-2-acetamido-.alpha.-d-galactopyranose
galactopyranose, 2-acetamido-2-deoxy-, .alpha.-d-
2-(acetylamino)-2-deoxy-.alpha.-d-galactopyranose
n-(2,4,5-trihydroxy-6-hydroxymethyl-tetrahydro-pyran-3-yl)-acetamide,(n-acetyl-d-
4OCQ
AKOS030228287
AS-63026
alpha-2-acetamido-2-deoxy-delta-galactose
2-acetylamino-2-deoxy-b-d-mannopyranose
2-acetylamino-a-d-2-deoxy-glucose
2-acetylamino-2-desoxy-a-d-mannose
2-acetamino-2-desoxy-d-glucose
2-acetylamino-2-deoxy-beta-delta-galactopyranose
2-acetamido-2-deoxy-a-d-glucopyranose
2-acetylamino-beta-d-2-deoxy-glucopyranose
2-acetylamino-2-deoxy-beta-d-altropyranose
2-acetylamino-delta-2-deoxy-mannose
2-acetylamino-2-deoxy-beta-d-galactopyranose
n-acetyl-delta-galactosamine
2-acetylamino-2-deoxy-alpha-d-glucopyranose
2-acetylamino-2-desoxy-beta-d-galaktose
2-acetamino-2-deoxy-alpha-delta-glucose
2-acetylamino-2-deoxy-alpha-d-galactopyranose
2-acetylamino-2-desoxy-b-d-mannose
2-acetylamino-2-deoxy-a-d-galactopyranose
n-acetylglucosamin
2-acetylamino-delta-2-deoxy-gulose
2-acetylamino-beta-delta-2-deoxy-mannopyranose
2-acetylamino-2-deoxy-alpha-delta-glucopyranose
2-acetamido-2-desoxy-beta-delta-talofuranose
2-acetylamino-d-2-deoxy-gulose
2-acetylamino-2-deoxy-beta-d-allopyranose
2-acetylamino-2-desoxy-alpha-delta-mannose
2-acetylamino-alpha-d-2-deoxy-galactopyranose
2-acetylamino-alpha-d-2-deoxy-glucose
2-acetylamino-d-2-deoxy-talose
2-acetamino-2-desoxy-delta-galaktose
n-acetyl-alpha-delta-glucosamine
2-acetylamino-2-deoxy-alpha-d-mannopyranose
2-acetylamino-2-desoxy-a-d-galaktose
2-acetylamino-l-2-deoxy-galactose
2-acetylamino-2-deoxy-alpha-delta-galactopyranose
2-acetamino-2-desoxy-a-d-glucopyranose
2-acetylamino-alpha-delta-2-deoxy-galactopyranose
2-acetylamino-2-deoxy-beta-d-mannopyranose
2-acetylamino-2-desoxy-alpha-delta-galaktose
2-acetylamino-d-2-deoxy-idose
2-acetylamino-d-2-deoxy-mannose
2-acetylamino-2-deoxy-alpha-delta-mannopyranose
2-acetylamino-alpha-delta-2-deoxy-mannopyranose
2-acetamido-2-deoxy-alpha-delta-glucopyranose
2-acetylamino-2-desoxy-beta-delta-mannose
alpha-2-acetamido-2-deoxy-d-galactose
2-acetylamino-2-desoxy-delta-mannose
2-acetamido-2-deoxy-b-d-glucopyranose
2-acetamido-2-desoxy-beta-d-talofuranose
2-acetamido-2-desoxy-b-d-talofuranose
2-acetylamino-2-deoxy-b-d-glucopyranose
2-acetylamino-l-2-deoxy-mannose
2-acetylamino-2-deoxy-beta-delta-altropyranose
n-acetyl-delta-allosamine
2-acetamido-2-deoxy-alpha-d-allopyranose
2-acetylamino-d-2-deoxy-galactose
2-acetamino-2-desoxy-delta-glucose
2-acetylamino-a-d-2-deoxy-glucopyranose
2-acetylamino-2-deoxy-beta-delta-mannopyranose
n-acetylgalactosamin
2-acetylamino-alpha-d-2-deoxy-glucopyranose
2-acetamino-2-deoxy-a-d-glucose
2-acetylamino-2-desoxy-beta-delta-galaktose
2-acetylamino-b-d-2-deoxy-galactopyranose
2-acetylamino-b-d-2-deoxy-mannopyranose
2-acetylamino-2-desoxy-beta-d-mannose
2-acetylamino-2-desoxy-b-d-galaktose
2-acetylamino-delta-2-deoxy-idose
2-acetylamino-beta-delta-2-deoxy-glucopyranose
2-acetylamino-beta-d-2-deoxy-mannopyranose
2-acetylamino-2-deoxy-a-d-mannopyranose
2-acetylamino-delta-2-deoxy-talose
2-acetylamino-a-d-2-deoxy-galactopyranose
2-acetamido-2-deoxy-a-d-allopyranose
2-acetylamino-b-d-2-deoxy-glucopyranose
2-acetylamino-2-deoxy-a-d-glucopyranose
2-acetylamino-2-deoxy-beta-d-glucopyranose
2-acetylamino-delta-2-deoxy-glucose
2-acetylamino-2-deoxy-b-d-altropyranose
2-acetylamino-beta-d-2-deoxy-galactopyranose
2-acetylamino-2-deoxy-beta-delta-allopyranose
2-acetylamino-2-deoxy-beta-delta-glucopyranose
2-acetamido-2-deoxy-beta-delta-glucopyranose
2-acetamino-2-desoxy-alpha-d-glucopyranose
2-acetamino-2-desoxy-d-galaktose
2-acetylamino-2-deoxy-b-d-galactopyranose
2-acetamido-2-deoxy-alpha-delta-allopyranose
2-acetylamino-delta-2-deoxy-galactose
2-acetylamino-beta-delta-2-deoxy-galactopyranose
2-acetylamino-2-desoxy-alpha-d-galaktose
2-acetylamino-d-2-deoxy-glucose
2-acetylamino-alpha-delta-2-deoxy-glucopyranose
n-acetylgluosamin
2-acetamino-2-deoxy-alpha-d-glucose
2-acetylamino-a-d-2-deoxy-mannopyranose
2-acetylamino-2-desoxy-d-mannose
2-acetylamino-2-desoxy-dl-glucopyranose
2-acetylamino-alpha-delta-2-deoxy-glucose
2-acetylamino-2-desoxy-alpha-d-mannose
2-acetamino-2-desoxy-alpha-delta-glucopyranose
n-acetylmannosamin
a-2-acetamido-2-deoxy-d-galactose
a-d-galactopyranose,2-(acetylamino)-2-deoxy-
n-((2s,3r,4r,5r,6r)-2,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2h-pyran-3-yl)acetamide
OVRNDRQMDRJTHS-CBQIKETKSA-N
galnacalpha
Q285835
SCHEMBL21196403
HY-128852
CS-0100924
n-?acetyl-?d-?galactosamine
D71054
DTXSID70884733
Z1509640224
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (1)

RoleDescription
epitopeThe biological role played by a material entity when bound by a receptor of the adaptive immune system. Specific site on an antigen to which an antibody binds.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
N-acetyl-D-galactosamineThe D-enantiomer of N-acetylgalactosamine.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (7)

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, LectinErythrina corallodendronKd746.0000515.0000632.6667746.0000AID977611
Chain A, LectinErythrina corallodendronKd746.0000515.0000632.6667746.0000AID977611
Chain A, LectinErythrina corallodendronKd746.0000515.0000632.6667746.0000AID977611
Chain A, LectinErythrina corallodendronKd746.0000515.0000632.6667746.0000AID977611
Chain A, Discoidin-2Dictyostelium discoideum AX2Kd1,150.0000950.00001,050.00001,150.0000AID977611
Chain A, Discoidin-2Dictyostelium discoideum AX2Kd1,150.0000950.00001,050.00001,150.0000AID977611
Chain A, LectinErythrina corallodendronKd431.0000431.0000431.0000431.0000AID977611
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (6)

Assay IDTitleYearJournalArticle
AID1811Experimentally measured binding affinity data derived from PDB1998Journal of molecular biology, Apr-10, Volume: 277, Issue:4
Structures of the Erythrina corallodendron lectin and of its complexes with mono- and disaccharides.
AID977611Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB1998Journal of molecular biology, Apr-10, Volume: 277, Issue:4
Structures of the Erythrina corallodendron lectin and of its complexes with mono- and disaccharides.
AID1853212Drug uptake in human HepG2 cells with ASGPR overexpression assessed as fold increase in intracellular uptake2022RSC medicinal chemistry, Dec-14, Volume: 13, Issue:12
Targeted protein degradation using the lysosomal pathway.
AID977611Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB2008Proteins, Oct, Volume: 73, Issue:1
Structure determination of Discoidin II from Dictyostelium discoideum and carbohydrate binding properties of the lectin domain.
AID977611Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB2011Acta crystallographica. Section D, Biological crystallography, Mar, Volume: 67, Issue:Pt 3
Modification of the sugar specificity of a plant lectin: structural studies on a point mutant of Erythrina corallodendron lectin.
AID977611Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB2014Acta crystallographica. Section D, Biological crystallography, May, Volume: 70, Issue:Pt 5
Insights into the binding specificity and catalytic mechanism of N-acetylhexosamine 1-phosphate kinases through multiple reaction complexes.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's1 (20.00)29.6817
2010's2 (40.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.07

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.07 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.86 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.07)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
lactose
Lactose: A disaccharide of GLUCOSE and GALACTOSE in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry.. lactose : A glycosylglucose disaccharide, found most notably in milk, that consists of D-galactose and D-glucose fragments bonded through a beta-1->4 glycosidic linkage. The glucose fragment can be in either the alpha- or beta-pyranose form, whereas the galactose fragment can only have the beta-pyranose form.. beta-lactose : The beta-anomer of lactose.		1.9910lactose
methyl beta-galactoside
methyl beta-galactoside: RN given refers to (beta-D)-isomer. methyl galactoside : A methyl glycoside in which the H of the OH group on C-1 of galactose is replaced by a methyl group.. methyl beta-D-galactoside : A beta-D-galactopyranoside having a methyl substituent at the anomeric position.		2.0410beta-D-galactoside;
methyl D-galactoside;
monosaccharide derivative
galactose
beta-D-galactose : A D-galactopyranose having beta-configuration at the anomeric centre.. beta-D-galactoside : Any D-galactoside having beta-configuration at its anomeric centre.		1.9910D-galactopyranoseepitope;
mouse metabolite
ConditionIndicatedRelationship StrengthStudiesTrials