Compounds > D-arabinopyranose
Page last updated: 2024-12-05

D-arabinopyranose

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

D-arabinopyranose is a sugar with the molecular formula C5H10O5. It is a cyclic form of the pentose arabinose. D-arabinopyranose is a component of several important biomolecules, including arabinans, arabinogalactans, and arabinoxylan. Arabinans are complex polysaccharides that are found in the cell walls of plants and are thought to play a role in cell wall structure and function. Arabinogalactans are polysaccharides that are found in the cell walls of plants and are thought to be involved in plant defense against pathogens. Arabinoxylans are polysaccharides that are found in the cell walls of grasses and are thought to be important for the digestion of plant material by animals. D-arabinopyranose is also a component of some antibiotics, such as vancomycin. The synthesis of D-arabinopyranose can be achieved by a variety of methods, including chemical synthesis and enzymatic synthesis. D-arabinopyranose is a valuable research tool for studying the structure and function of carbohydrates. It is also a potential target for the development of new drugs.'
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D-arabinopyranose : D-Arabinose in its pyranose form. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID6902
CHEMBL ID1222249
CHEBI ID46994
SCHEMBL ID112598

Synonyms (30)

Synonym
O_FULL_00000100000000_GS_790
CHEMBL1222249
C00216
d-(-)-arabinose, >=98%
d-(-)-arabinose, bioxtra, >=98%
NCGC00165986-01
d-arabinopyranose
28697-53-2
CHEBI:46994 ,
A-8200
03CC4623-88D1-42C5-8561-3E19735C47D4
(3s,4r,5r)-oxane-2,3,4,5-tetrol
(3s,4r,5r)-tetrahydro-2h-pyran-2,3,4,5-tetraol
S5134
SCHEMBL112598
AKOS016843688
mfcd00064361
d-(-)-arabinose, 99%
d-(-)-arabinose, for microbiology, >=99.0%
d-(-)-arabinose, 98.5%
d-?arabinose
HY-N7082
(3s,4r,5r)-tetrahydropyran-2,3,4,5-tetrol
Q27120748
AS-12470
CCG-266200
CS-0030746
DTXSID101316251
EN300-107811
Z1255360576
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
D-arabinose
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (3)

PathwayProteinsCompounds
D-Arabinose Degradation I511
GDP-arabinose biosynthesis08
ascorbate biosynthesis018

Protein Targets (1)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency2.23870.251215.843239.8107AID504327
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID30428Compound was tested for inhibition of Human acrosin by aldopentoses1981Journal of medicinal chemistry, Nov, Volume: 24, Issue:11
Inhibition of human acrosin by monosaccharides and related compounds: structure-activity relationships.
AID1711521Growth inhibition of Caenorhabditis elegans N2 L1 larvae under monoxenic condition assessed as reduction in body size at 42 mM incubated for 72 hrs by microscopic method relative to control2016Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
Growth inhibitory effect of D-arabinose against the nematode Caenorhabditis elegans: Discovery of a novel bioactive monosaccharide.
AID1278462Induction of ROS generation in human NCI-H1299 cells at <= 100 uM after 5 hrs by DCF-DA staining-based assay2016Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5
Carbohydrate-based inducers of cellular stress for targeting cancer cells.
AID1711524Growth inhibition of Caenorhabditis elegans N2 assessed as reduction in body size at 10 mM in presence of D-fructose by microscopic method2016Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
Growth inhibitory effect of D-arabinose against the nematode Caenorhabditis elegans: Discovery of a novel bioactive monosaccharide.
AID389314Increase in [3H]2-deoxy-D-glucose uptake in rat L6 cells at 20 mM preincubated 24 hrs with D-glucose assessed after 6 hrs relative to control2008Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
Novel D-xylose derivatives stimulate muscle glucose uptake by activating AMP-activated protein kinase alpha.
AID1711517Growth inhibition of Caenorhabditis elegans N2 L1 larvae under axenic condition assessed as reduction in body size at 16 mM incubated for 7 days by microscopic method relative to control2016Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
Growth inhibitory effect of D-arabinose against the nematode Caenorhabditis elegans: Discovery of a novel bioactive monosaccharide.
AID500279Ratio of Kcat to Km for Neisseria meningitidis lgtC2006Nature chemical biology, Dec, Volume: 2, Issue:12
Using substrate engineering to harness enzymatic promiscuity and expand biological catalysis.
AID1711520Toxicity in Caenorhabditis elegans N2 under monoxenic condition with Escherichia coli food assessed as mortality at 42 mM incubated for 72 hrs by microscopic method relative to control2016Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
Growth inhibitory effect of D-arabinose against the nematode Caenorhabditis elegans: Discovery of a novel bioactive monosaccharide.
AID30429Compound was tested for inhibition of Human acrosin by aldoses1981Journal of medicinal chemistry, Nov, Volume: 24, Issue:11
Inhibition of human acrosin by monosaccharides and related compounds: structure-activity relationships.
AID1711518Growth inhibition of Caenorhabditis elegans N2 L1 larvae under monoxenic condition with Escherichia coli food assessed as reduction in body size at 42 mM incubated for 72 hrs by microscopic method relative to control2016Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
Growth inhibitory effect of D-arabinose against the nematode Caenorhabditis elegans: Discovery of a novel bioactive monosaccharide.
AID1711519Growth inhibition of Caenorhabditis elegans N2 L1 larvae under monoxenic condition with Escherichia coli food assessed as reduction in motility at 42 mM incubated for 72 hrs by microscopic method relative to control2016Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
Growth inhibitory effect of D-arabinose against the nematode Caenorhabditis elegans: Discovery of a novel bioactive monosaccharide.
AID1711523Growth inhibition of Caenorhabditis elegans N2 assessed as reduction in body size at 10 mM in presence of 125 mM D-glucose by microscopic method2016Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
Growth inhibitory effect of D-arabinose against the nematode Caenorhabditis elegans: Discovery of a novel bioactive monosaccharide.
AID1711522Growth inhibition of Caenorhabditis elegans N2 assessed as reduction in body size at 10 mM in presence of D-ribose by microscopic method2016Bioorganic & medicinal chemistry letters, Feb-01, Volume: 26, Issue:3
Growth inhibitory effect of D-arabinose against the nematode Caenorhabditis elegans: Discovery of a novel bioactive monosaccharide.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 45.41

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index45.41 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index65.76 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (45.41)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
dihydroxyacetone
[no description available]		1.9610ketotriose;
primary alpha-hydroxy ketone		antifungal agent;
Escherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
glycerol
Moon: The natural satellite of the planet Earth. It includes the lunar cycles or phases, the lunar month, lunar landscapes, geography, and soil.		1.9610alditol;
triol		algal metabolite;
detergent;
Escherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
solvent
inositol
Inositol: An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.. inositol : Any cyclohexane-1,2,3,4,5,6-hexol.. 1D-chiro-inositol : Belonging to the inositol family of compounds, D-chiro-inositol (DCI) is an isomer of glucose. It is an important secondary messenger in insulin signal transduction.. muco-inositol : An inositol that is cyclohexane-1,2,3,4,5,6-hexol having a (1R,2R,3r,4R,5S,6r)-configuration.		2.3920cyclitol;
hexol
sorbose
[no description available]		1.9610
2,4-dinitrophenol
2,4-Dinitrophenol: A toxic dye, chemically related to trinitrophenol (picric acid), used in biochemical studies of oxidative processes where it uncouples oxidative phosphorylation. It is also used as a metabolic stimulant. (Stedman, 26th ed). dinitrophenol : Members of the class of nitrophenol carrying two nitro substituents.. 2,4-dinitrophenol : A dinitrophenol having the nitro groups at the 2- and 4-positions.		2.0410dinitrophenolallergen;
antiseptic drug;
bacterial xenobiotic metabolite;
geroprotector;
oxidative phosphorylation inhibitor
D-ribofuranose
ribofuranose : A cyclic ribose having a 5-membered tetrahydrofuran ring; the predominant (C3'-endo) form of the two cyclic structures (the other is the "C2'-endo" form, having a 6-membered ring) adopted by ribose in aqueous solution.		2.1310D-ribose;
ribofuranose
sorbitol
D-glucitol : The D-enantiomer of glucitol (also known as D-sorbitol).		2.3920glucitolcathartic;
Escherichia coli metabolite;
food humectant;
human metabolite;
laxative;
metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite;
sweetening agent
galactose
galactopyranose : The pyranose form of galactose.		2.0310D-galactose;
galactopyranose		Escherichia coli metabolite;
mouse metabolite
lactose
Lactose: A disaccharide of GLUCOSE and GALACTOSE in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry.. lactose : A glycosylglucose disaccharide, found most notably in milk, that consists of D-galactose and D-glucose fragments bonded through a beta-1->4 glycosidic linkage. The glucose fragment can be in either the alpha- or beta-pyranose form, whereas the galactose fragment can only have the beta-pyranose form.. beta-lactose : The beta-anomer of lactose.		2.0310lactose
mannitol
[no description available]		1.9610mannitolallergen;
antiglaucoma drug;
compatible osmolytes;
Escherichia coli metabolite;
food anticaking agent;
food bulking agent;
food humectant;
food stabiliser;
food thickening agent;
hapten;
metabolite;
osmotic diuretic;
sweetening agent
1-naphthylamine
1-Naphthylamine: A suspected industrial carcinogen (and listed as such by OSHA). Its N-hydroxy metabolite is strongly carcinogenic and mutagenic.. naphthylamine : A primary arylamine that is naphthalene substituted by an amino group at unspecified position.. 1-naphthylamine : A naphthylamine that is naphthalene substituted by an amino group at position 1.		2.1310naphthylaminehuman xenobiotic metabolite
fructose-1,6-diphosphate
beta-D-fructofuranose 1,6-bisphosphate : A D-fructofuranose 1,6-bisphosphate with a beta-configuration at the anomeric position.		1.9610D-fructofuranose 1,6-bisphosphatemouse metabolite
fucose
Fucose: A six-member ring deoxysugar with the chemical formula C6H12O5. It lacks a hydroxyl group on the carbon at position 6 of the molecule.. L-fucopyranose : The pyranose form of L-fucose.. fucose : Any deoxygalactose that is deoxygenated at the 6-position.		1.9610fucopyranose;
L-fucose		Escherichia coli metabolite;
mouse metabolite
mannose
mannopyranose : The pyranose form of mannose.		2.3920D-aldohexose;
D-mannose;
mannopyranose		metabolite
octyl glucoside
octyl-beta-D-glucoside: RN given refers to (beta)-isomer. octyl beta-D-glucopyranoside : An beta-D-glucoside in which the anomeric hydrogen of beta-D-glucopyranose is substituted by an octyl group.		2.0310beta-D-glucosideplant metabolite
aica ribonucleotide
AICA ribonucleotide: purine precursor that has antineoplastic activity. AICA ribonucleotide : A 1-(phosphoribosyl)imidazolecarboxamide that is acadesine in which the hydroxy group at the 5' position has been converted to its monophosphate derivative.		2.04101-(phosphoribosyl)imidazolecarboxamide;
aminoimidazole		cardiovascular drug;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
arabitol
arabitol: RN given refers to cpd without isomeric designation. arabinitol : A pentitol that is the sugar alcohol produced by the reduction of arabinose or lyxose. It is found in serum or urine of human infected with Candida albicans.. D-arabinitol : The D-enantiomer of arabinitol.		2.1310arabinitol
xylose
xylopyranose: structure in first source		3.1250D-xylose
arabinose
[no description available]		2.420L-arabinoseEscherichia coli metabolite;
mouse metabolite
lyxose
D-lyxose : Any lyxose having D-configuration.. D-lyxopyranose : The pyranose form of D-lyxose.		2.1310D-lyxose
deoxyglucose
2-deoxy-D-glucopyranose : A 2-deoxy-D-glucose that is D-glucopyranose in which the hydroxy group at position 2 has been replaced by a hydrogen.		2.53202-deoxy-D-glucosemetabolite
galactose
beta-D-galactose : A D-galactopyranose having beta-configuration at the anomeric centre.. beta-D-galactoside : Any D-galactoside having beta-configuration at its anomeric centre.		1.9610D-galactopyranoseepitope;
mouse metabolite
galactose
alpha-D-galactoside : Any D-galactoside having alpha-configuration at its anomeric centre.		1.9610D-galactopyranosemouse metabolite
allose
[no description available]		2.0310allopyranose;
D-allose		antioxidant
gulose
gulose: RN given refers to cpd without isomeric designation. gulopyranose : The pyranose form of gulose.. gulose : An aldohexose that is the C-3 epimer of galactose.		1.9610D-aldohexose;
D-gulose;
gulopyranose
ConditionIndicatedRelationship StrengthStudiesTrials
Diabetes Mellitus, Adult-Onset
[description not available]		02.0410
Diabetes Mellitus, Type 2
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.		02.0410