9-aminoellipticine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

9-Aminoellipticine is a synthetic ellipticine derivative that exhibits potent antitumor activity. It is an intercalating agent that binds to DNA, inhibiting DNA replication and transcription. The compound's synthesis involves several steps starting from ellipticine, a natural product isolated from the plant *Ochrosia grandiflora*. 9-aminoellipticine has shown promising preclinical results against various types of cancer, including leukemia, lung cancer, and breast cancer. It is studied because of its unique mechanism of action and its potential as a novel anticancer drug. However, its clinical development has been limited due to toxicity concerns.'

9-aminoellipticine: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	99172
SCHEMBL ID	3342543
MeSH ID	M0115579

Synonyms (16)

Synonym
nsc 191345
icig 1089
6h-pyrido(4,3-b)carbazol-9-amine, 5,11-dimethyl-
brn 0754366
5,11-dimethyl-6h-pyrido(4,3-b)carbazol-9-amine
ccris 6481
6h-pyrido[4,3-b]carbazol-9-amine, 5,11-dimethyl-
nsc191345
nsc-191345
9-aminoellipticine
54779-53-2
5,11-dimethyl-6h-pyrido[4,3-b]carbazol-9-amine
SCHEMBL3342543
DTXSID30970101
aminoellipticine, 9-
626V38C3NM

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	8 (53.33)	18.7374
1990's	7 (46.67)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.65

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	11.65 (24.57)
Research Supply Index	2.77 (2.92)
Research Growth Index	4.43 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (11.65)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	15 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
uracil 2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder	1.96	1	pyrimidine nucleobase; pyrimidone	allergen; Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; prodrug; Saccharomyces cerevisiae metabolite
ellipticine ellipticine : A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.	6.97	1	indole alkaloid; organic heterotetracyclic compound; organonitrogen heterocyclic compound; polycyclic heteroarene	antineoplastic agent; plant metabolite
erythrosine Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.	1.96	1
ethidium Ethidium: A trypanocidal agent and possible antiviral agent that is widely used in experimental cell biology and biochemistry. Ethidium has several experimentally useful properties including binding to nucleic acids, noncompetitive inhibition of nicotinic acetylcholine receptors, and fluorescence among others. It is most commonly used as the bromide.. ethidium : The fluorescent compound widely used in experimental cell biology and biochemistry to reveal double-stranded DNA and RNA.	1.96	1	phenanthridines	fluorochrome; intercalator
dimethyl sulfate dimethyl sulfate: RN given refers to unlabeled cpd; structure. dimethyl sulfate : The dimethyl ester of sulfuric acid.	1.97	1	alkyl sulfate	alkylating agent; immunosuppressive agent
acridines Acridines: Compounds that include the structure of acridine.. acridine : A polycyclic heteroarene that is anthracene in which one of the central CH groups is replaced by a nitrogen atom.	1.97	1	acridines; mancude organic heterotricyclic parent; polycyclic heteroarene	genotoxin
9-methoxyellipticine 9-methoxyellipticine: RN given refers to parent cpd	1.96	1
6-carboxyfluorescein 6-carboxyfluorescein: originally sold as 6-carboxyfluorescein, but commercial product is a mixture of two isomers; correct name is 5(6)-carboxyfluorescein	1.96	1	monocarboxylic acid
9-hydroxyellipticine 9-hydroxyellipticine: RN given refers to parent cpd. 9-hydroxyellipticine : A organic heterotetracyclic compound that is ellipticine in which the hydrogen at position 9 has been replaced by a hydroxy group.	1.97	1	organic heterotetracyclic compound; organonitrogen heterocyclic compound	antineoplastic agent
oligonucleotides [no description available]	1.97	1
sodium cyanoborohydride sodium cyanoborohydride: reagent for preparing biologically active nitroxides	1.97	1

Condition	Indicated	Relationship Strength	Studies	Trials
Extravascular Hemolysis [description not available]	0	1.96	1	0
Hemolysis The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.	0	1.96	1	0

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