Compounds > 9-aminoellipticine
Page last updated: 2024-12-07

9-aminoellipticine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

9-Aminoellipticine is a synthetic ellipticine derivative that exhibits potent antitumor activity. It is an intercalating agent that binds to DNA, inhibiting DNA replication and transcription. The compound's synthesis involves several steps starting from ellipticine, a natural product isolated from the plant *Ochrosia grandiflora*. 9-aminoellipticine has shown promising preclinical results against various types of cancer, including leukemia, lung cancer, and breast cancer. It is studied because of its unique mechanism of action and its potential as a novel anticancer drug. However, its clinical development has been limited due to toxicity concerns.'

9-aminoellipticine: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID99172
SCHEMBL ID3342543
MeSH IDM0115579

Synonyms (16)

Synonym
nsc 191345
icig 1089
6h-pyrido(4,3-b)carbazol-9-amine, 5,11-dimethyl-
brn 0754366
5,11-dimethyl-6h-pyrido(4,3-b)carbazol-9-amine
ccris 6481
6h-pyrido[4,3-b]carbazol-9-amine, 5,11-dimethyl-
nsc191345
nsc-191345
9-aminoellipticine
54779-53-2
5,11-dimethyl-6h-pyrido[4,3-b]carbazol-9-amine
SCHEMBL3342543
DTXSID30970101
aminoellipticine, 9-
626V38C3NM
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (15)

TimeframeStudies, This Drug (%)All Drugs %
pre-19908 (53.33)18.7374
1990's7 (46.67)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.65

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.65 (24.57)
Research Supply Index2.77 (2.92)
Research Growth Index4.43 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.65)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other15 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
uracil
2,4-dihydroxypyrimidine: a urinary biomarker for bipolar disorder		1.9610pyrimidine nucleobase;
pyrimidone		allergen;
Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
prodrug;
Saccharomyces cerevisiae metabolite
ellipticine
ellipticine : A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.		6.9710indole alkaloid;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound;
polycyclic heteroarene		antineoplastic agent;
plant metabolite
erythrosine
Fluoresceins: A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.		1.9610
ethidium
Ethidium: A trypanocidal agent and possible antiviral agent that is widely used in experimental cell biology and biochemistry. Ethidium has several experimentally useful properties including binding to nucleic acids, noncompetitive inhibition of nicotinic acetylcholine receptors, and fluorescence among others. It is most commonly used as the bromide.. ethidium : The fluorescent compound widely used in experimental cell biology and biochemistry to reveal double-stranded DNA and RNA.		1.9610phenanthridinesfluorochrome;
intercalator
dimethyl sulfate
dimethyl sulfate: RN given refers to unlabeled cpd; structure. dimethyl sulfate : The dimethyl ester of sulfuric acid.		1.9710alkyl sulfatealkylating agent;
immunosuppressive agent
acridines
Acridines: Compounds that include the structure of acridine.. acridine : A polycyclic heteroarene that is anthracene in which one of the central CH groups is replaced by a nitrogen atom.		1.9710acridines;
mancude organic heterotricyclic parent;
polycyclic heteroarene		genotoxin
9-methoxyellipticine
9-methoxyellipticine: RN given refers to parent cpd		1.9610
6-carboxyfluorescein
6-carboxyfluorescein: originally sold as 6-carboxyfluorescein, but commercial product is a mixture of two isomers; correct name is 5(6)-carboxyfluorescein		1.9610monocarboxylic acid
9-hydroxyellipticine
9-hydroxyellipticine: RN given refers to parent cpd. 9-hydroxyellipticine : A organic heterotetracyclic compound that is ellipticine in which the hydrogen at position 9 has been replaced by a hydroxy group.		1.9710organic heterotetracyclic compound;
organonitrogen heterocyclic compound		antineoplastic agent
oligonucleotides
[no description available]		1.9710
sodium cyanoborohydride
sodium cyanoborohydride: reagent for preparing biologically active nitroxides		1.9710
ConditionIndicatedRelationship StrengthStudiesTrials
Extravascular Hemolysis
[description not available]		01.9610
Hemolysis
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.		01.9610