Page last updated: 2024-12-06

9-(4-methylanilino)-acridine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

9-(4-methylanilino)-acridine: RN given refers to parent cpd; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID51971
CHEMBL ID51599
SCHEMBL ID15673568
MeSH IDM0090746

Synonyms (17)

Synonym
brn 0228520
9-(p-toluidino)acridine
9-(4-methylanilino)-acridine
acridine, 9-(p-toluidino)-
AKOS005443022
n-(acridin-9(10h)-ylidene)-4-methylaniline
STK366616
acridin-9-yl-p-tolyl-amine
CHEMBL51599
STL088544
n-(4-methylphenyl)acridin-9-amine
AKOS000599250
73655-57-9
DTXSID20223870
SCHEMBL15673568
n-(4-methylphenyl)-9-acridinamine #
KTFWKOXVMZSFHO-UHFFFAOYSA-N
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (12)

Assay IDTitleYearJournalArticle
AID24208Association constant for binding to poly [d(A-T)]1981Journal of medicinal chemistry, Feb, Volume: 24, Issue:2
Potential antitumor agents. 34. Quantitative relationships between DNA binding and molecular structure for 9-anilinoacridines substituted in the anilino ring.
AID116415Maximum percent increase in life span of mice was determined by L1210 assay1981Journal of medicinal chemistry, Feb, Volume: 24, Issue:2
Potential antitumor agents. 34. Quantitative relationships between DNA binding and molecular structure for 9-anilinoacridines substituted in the anilino ring.
AID210614Compound concentration in mole/kg/day lethal to 10% of mice1982Journal of medicinal chemistry, Mar, Volume: 25, Issue:3
Potential antitumor agents. 36. Quantitative relationships between experimental antitumor activity, toxicity, and structure for the general class of 9-anilinoacridine antitumor agents.
AID25559Ionization constant (pKa)1982Journal of medicinal chemistry, Mar, Volume: 25, Issue:3
Potential antitumor agents. 36. Quantitative relationships between experimental antitumor activity, toxicity, and structure for the general class of 9-anilinoacridine antitumor agents.
AID100307Dose of the drug (mol /kg) providing a 50% life extension in L1210 assays when given at qd 1-5 schedule; No data1987Journal of medicinal chemistry, Mar, Volume: 30, Issue:3
Redox chemistry of the 9-anilinoacridine class of antitumor agents.
AID46149Inhibitory concentration against ethidium binding to DNA1981Journal of medicinal chemistry, Feb, Volume: 24, Issue:2
Potential antitumor agents. 34. Quantitative relationships between DNA binding and molecular structure for 9-anilinoacridines substituted in the anilino ring.
AID116709Drug dose that is lethal to 10% of animals was measured1981Journal of medicinal chemistry, Feb, Volume: 24, Issue:2
Potential antitumor agents. 34. Quantitative relationships between DNA binding and molecular structure for 9-anilinoacridines substituted in the anilino ring.
AID26375Ionisation constant (pKa)1981Journal of medicinal chemistry, Feb, Volume: 24, Issue:2
Potential antitumor agents. 34. Quantitative relationships between DNA binding and molecular structure for 9-anilinoacridines substituted in the anilino ring.
AID24209Association constant for binding to poly [d(G-C)]1981Journal of medicinal chemistry, Feb, Volume: 24, Issue:2
Potential antitumor agents. 34. Quantitative relationships between DNA binding and molecular structure for 9-anilinoacridines substituted in the anilino ring.
AID97604Tumor cell selectivity determined as maximal percent increase in life span (ILSmax) at LD10 dosage level in L1210 cells1982Journal of medicinal chemistry, Aug, Volume: 25, Issue:8
Structure-antitumor activity relationships of 9-anilinoacridines using pattern recognition.
AID98491Inhibitory concentration to reduce the growth of L1210 cells by 50% after 70 h; No data1987Journal of medicinal chemistry, Mar, Volume: 30, Issue:3
Redox chemistry of the 9-anilinoacridine class of antitumor agents.
AID98819Drug concentration in mole/kg/day providing 50% extension of life in intraperitoneally implanted leukemia L1210 mice.1982Journal of medicinal chemistry, Mar, Volume: 25, Issue:3
Potential antitumor agents. 36. Quantitative relationships between experimental antitumor activity, toxicity, and structure for the general class of 9-anilinoacridine antitumor agents.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19906 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.50

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.50 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.45 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.50)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]