9-(4-fluoro-3-hydroxymethylbutyl)guanine profile

ID Source	ID
PubMed CID	135487454
CHEMBL ID	220519
SCHEMBL ID	60175
MeSH ID	M0292684

Synonym
CHEMBL220519 ,
bdbm50205237
9-(4-fluoro-3-hydroxymethylbutyl)guanine
SCHEMBL60175
206067-83-6
6h-purin-6-one, 2-amino-9-[4-(fluoro)-3-(hydroxymethyl)butyl]-1,9-dihydro
J2.034.785F ,
9-(4-fluoro-3-(hydroxymethyl)butyl)guanine
fhbg
6h-purin-6-one, 2-amino-9-(4-fluoro-3-(hydroxymethyl)butyl)-1,9-dihydro-
14u77vre8l ,
unii-14u77vre8l
2-amino-9-(4-fluoro-3-(hydroxymethyl)butyl)-1h-purin-6(9h)-one
9-[4-fluoro-3-(hydroxymethyl)butyl]guanine
Q27251651
2-amino-9-[3-(fluoromethyl)-4-hydroxybutyl]-1h-purin-6-one
2-amino-9-[3-(fluoromethyl)-4-hydroxybutyl]-6,9-dihydro-1h-purin-6-one

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Thymidine kinase	Human alphaherpesvirus 1 (Herpes simplex virus type 1)	IC50 (µMol)	9.0000	0.1500	4.8167	9.0000	AID280124
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Assay ID	Title	Year	Journal	Article
AID280123	Inhibition of recombinant VZV TK assessed as [CH3-H3]dThd phosphorylation	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Synthesis and preliminary evaluation of 18F- or 11C-labeled bicyclic nucleoside analogues as potential probes for imaging varicella-zoster virus thymidine kinase gene expression using positron emission tomography.
AID280124	Inhibition of recombinant HSV-1 TK assessed as [CH3-H3]dThd phosphorylation	2007	Journal of medicinal chemistry, Mar-08, Volume: 50, Issue:5	Synthesis and preliminary evaluation of 18F- or 11C-labeled bicyclic nucleoside analogues as potential probes for imaging varicella-zoster virus thymidine kinase gene expression using positron emission tomography.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (2.17)	18.2507
2000's	37 (80.43)	29.6817
2010's	8 (17.39)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	3 (6.12%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	1 (2.04%)	4.05%
Observational	0 (0.00%)	0.25%
Other	45 (91.84%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
fluorouracil Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.	2.05	1	0	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic
spiperone Spiperone: A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.. spiperone : An azaspiro compound that is 1,3,8-triazaspiro[4.5]decane which is substituted at positions 1, 4, and 8 by phenyl, oxo, and 4-(p-fluorophenyl)-4-oxobutyl groups, respectively.	2.42	2	0	aromatic ketone; azaspiro compound; organofluorine compound; piperidines; tertiary amino compound	alpha-adrenergic antagonist; antipsychotic agent; dopaminergic antagonist; psychotropic drug; serotonergic antagonist
thymidine [no description available]	3.46	1	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite
pyrimidine pyrimidine : The parent compound of the pyrimidines; a diazine having the two nitrogens at the 1- and 3-positions.	2.04	1	0	diazine; pyrimidines	Daphnia magna metabolite
alovudine [no description available]	2.07	1	0	pyrimidine 2',3'-dideoxyribonucleoside
fialuridine [no description available]	2.42	2	0
fluorodeoxyglucose f18 Fluorodeoxyglucose F18: The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162)	3.27	6	0	2-deoxy-2-((18)F)fluoro-D-glucose; 2-deoxy-2-fluoro-aldehydo-D-glucose
3-n-(2-fluoroethyl)spiperone 3-N-(2-fluoroethyl)spiperone: structure given in first source	2.42	2	0
2'-fluorothymidine [no description available]	3.83	2	1
arabinofuranosyluracil Arabinofuranosyluracil: A pyrimidine nucleoside formed in the body by the deamination of CYTARABINE.	4.51	5	1
acyclovir Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections.	2.72	3	0	2-aminopurines; oxopurine	antimetabolite; antiviral drug
guanine [no description available]	8.85	45	3	2-aminopurines; oxopurine; purine nucleobase	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
ganciclovir [no description available]	4.8	7	1	2-aminopurines; oxopurine	antiinfective agent; antiviral drug
penciclovir penciclovir : A member of the class of 2-aminopurines that is guanine in which the hydrogen at position 9 is substituted by a 4-hydroxy-3-(hydroxymethyl)but-1-yl group. An antiviral drug, it is administered topically for treatment of herpes labialis. A prodrug, famciclovir, is used for oral administration.	2.42	2	0	2-aminopurines; propane-1,3-diols	antiviral drug

Condition	Relationship Strength	Studies	Trials
Graft-Versus-Host Disease [description not available]	3.5	1	1
Graft vs Host Disease The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.	3.5	1	1
Benign Neoplasms, Brain [description not available]	2.05	1	0
Astrocytoma, Grade IV [description not available]	2.05	1	0
Brain Neoplasms Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.	2.05	1	0
Glioblastoma A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.	2.05	1	0
Cancer of Prostate [description not available]	2.05	1	0
Prostatic Neoplasms Tumors or cancer of the PROSTATE.	2.05	1	0
Cardiovascular Stroke [description not available]	2.46	2	0
Myocardial Infarction NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).	2.46	2	0
Adenocarcinoma, Basal Cell [description not available]	2.05	1	0
Breast Cancer [description not available]	2.44	2	0
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	2.05	1	0
Breast Neoplasms Tumors or cancer of the human BREAST.	2.44	2	0
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.07	1	0
Disease, Pulmonary [description not available]	2.01	1	0
Lung Diseases Pathological processes involving any part of the LUNG.	2.01	1	0
Adenovirus Infections [description not available]	2.01	1	0
Glial Cell Tumors [description not available]	2.71	3	0
Adenoviridae Infections Virus diseases caused by the ADENOVIRIDAE.	2.01	1	0
Glioma Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)	2.71	3	0
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	5.01	3	1
Heart Disease, Ischemic [description not available]	2.02	1	0
Myocardial Ischemia A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).	2.02	1	0
Injury, Ischemia-Reperfusion [description not available]	2.02	1	0
Reperfusion Injury Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.	2.02	1	0
Hepatocellular Carcinoma [description not available]	4.32	1	1
Cancer of Liver [description not available]	4.32	1	1
Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.	4.32	1	1
Liver Neoplasms Tumors or cancer of the LIVER.	4.32	1	1
Infections, Retroviridae [description not available]	2.43	2	0
EHS Tumor [description not available]	2.43	2	0
Fibroma, Shope [description not available]	2.43	2	0
Retroviridae Infections Virus diseases caused by the RETROVIRIDAE.	2.43	2	0
Alloxan Diabetes [description not available]	2.03	1	0
Cancer of Lung [description not available]	2.03	1	0
Malignant Melanoma [description not available]	2.03	1	0
Metastase [description not available]	2.03	1	0
Lung Neoplasms Tumors or cancer of the LUNG.	2.03	1	0
Melanoma A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)	2.03	1	0
Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	2.03	1	0
Cancer of Colon [description not available]	2.42	2	0
Colonic Neoplasms Tumors or cancer of the COLON.	2.42	2	0
Viral Diseases [description not available]	1.99	1	0
Virus Diseases A general term for diseases caused by viruses.	1.99	1	0
Cytomegalovirus A genus of the family HERPESVIRIDAE, subfamily BETAHERPESVIRINAE, infecting the salivary glands, liver, spleen, lungs, eyes, and other organs, in which they produce characteristically enlarged cells with intranuclear inclusions. Infection with Cytomegalovirus is also seen as an opportunistic infection in AIDS.	2	1	0
Cardiovascular Diseases Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.	2.01	1	0

9-(4-fluoro-3-hydroxymethylbutyl)guanine

Cross-References

Synonyms (17)

Protein Targets (1)

Inhibition Measurements

Bioassays (2)

Research

Studies (46)

Study Types

9-(4-fluoro-3-hydroxymethylbutyl)guanine

Cross-References

Synonyms (17)

Protein Targets (1)

Inhibition Measurements

Bioassays (2)

Research

Studies (46)

Study Types

Related Drugs (14)

Related Conditions (47)