9-(3-fluoro-2-phosphonylmethoxypropyl)adenine

Description

9-(3-fluoro-2-phosphonylmethoxypropyl)adenine: highly selective antiretroviral agent in vivo & vitro; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	122652
SCHEMBL ID	384145
MeSH ID	M0189243

Synonyms (17)

Synonym
phosphonic acid, [[2-(6-amino-9h-purin-9-yl)-1-(fluoromethyl)ethoxy]methyl]-, (1)-
135295-27-1
[1-[(6-aminopurin-9-yl)methyl]-2-fluoro-ethoxy]methylphosphonic acid
(rs)-9-[(3-fluoro-2-(phosphonylmethoxy)propyl]adenine
fpmpa
[1-(6-aminopurin-9-yl)-3-fluoropropan-2-yl]oxymethylphosphonic acid
phosphonic acid, ((2-(6-amino-9h-purin-9-yl)-1-(fluoromethyl)ethoxy)methyl)-, (+-)-
3-fpmpa
9-(3-fluoro-2-phosphonylmethoxypropyl)adenine
SCHEMBL384145
[1-[[(9r)-6-aminopurin-9-yl]methyl]-2-fluoro-ethoxy]methylphosphonic acid
[1-[[(9s)-6-aminopurin-9-yl]methyl]-2-fluoro-ethoxy]methylphosphonic acid
({[1-(6-amino-9h-purin-9-yl)-3-fluoropropan-2-yl]oxy}methyl)phosphonic acid
DTXSID50928947
CS-0645958
HY-153005
(2rs)-fpmpa

Research

Studies (7)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	7 (100.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	2 (28.57%)	5.53%
Reviews	2 (28.57%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	3 (42.86%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Description	Relationhip Strength	Studies	Trials	Classes	Roles
9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine	[no description available]	medium	1	0
adenine	[no description available]	medium	7	2	6-aminopurines; purine nucleobase	Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
adefovir	[no description available]	medium	6	2	6-aminopurines; ether; phosphonic acids	antiviral drug; DNA synthesis inhibitor; drug metabolite; HIV-1 reverse transcriptase inhibitor; nephrotoxic agent
organophosphonates	[no description available]	medium	7	2	divalent inorganic anion; phosphite ion
cidofovir anhydrous	[no description available]	medium	2	0	phosphonic acids; pyrimidone	anti-HIV agent; antineoplastic agent; antiviral drug; photosensitizing agent
cytosine	[no description available]	medium	2	0	aminopyrimidine; pyrimidine nucleobase; pyrimidone	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
1,n(6)-ethenoadenine	[no description available]	medium	1	0	imidazo[2,1-i]purine	mutagen

Condition	Relationship Strength	Studies	Trials
Acquired Immune Deficiency Syndrome	low	1	0
Acquired Immuno-Deficiency Syndrome	low	1	0
Acquired Immunodeficiency Syndrome	low	1	0
AIDS	low	1	0
AIDS, Feline	medium	2	2
B Virus Infection	low	1	0
Cell Transformation, Neoplastic	low	1	0
FAIDS	medium	2	2
Feline Acquired Immune Deficiency Syndrome	medium	2	2
Feline Acquired Immuno-Deficiency Syndrome	medium	2	2
Feline Acquired Immunodeficiency Syndrome	medium	2	2
Feline AIDS	medium	2	2
Herpesviridae Infections	low	1	0
Herpesvirus Infections	low	1	0
HIV	low	1	0
Immunodeficiency Syndrome, Acquired	low	1	0
Immunologic Deficiency Syndrome, Acquired	low	1	0
Infections, Herpesviridae	low	1	0
Infections, Herpesvirus	low	1	0
Infections, Retroviridae	low	1	0
Infections, Retrovirus	low	1	0
Mucositis, Oral	medium	1	1
Neoplastic Cell Transformation	low	1	0
Neoplastic Transformation, Cell	low	1	0
Oral Mucositis	medium	1	1
Oromucositis	medium	1	1
Retroviridae Infections	low	1	0
Retrovirus Infections	low	1	0
Stomatitis	medium	1	1
Transformation, Neoplastic Cell	low	1	0
Tumorigenic Transformation	low	1	0
Xenotropic MuLV-related Virus Infection	low	1	0
Xenotropic Murine Leukemia Virus-related Virus Infection	low	1	0
XMRV Infection	low	1	0

Research Highlights

Long-term Use (1)

Article	Year
Enhancement of natural killer activity and interferon induction by different acyclic nucleoside phosphonates. Antiviral research, Volume: 23, Issue: 1	1994
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (1)

Article	Year
[Comparative investigation of the efficacy of two nucleocapsid analogs in FIV infected cats]. Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere, Volume: 25, Issue: 6	1997
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]