Compounds > 8-hydroxyserrulat-14-en-19-oic acid
Page last updated: 2024-11-13

8-hydroxyserrulat-14-en-19-oic acid

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Description

8-hydroxyserrulat-14-en-19-oic acid: antimicrobial compound from the Australian desert plant Eremophila neglecta; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
Eremophilagenus[no description available]ScrophulariaceaeThe figwort plant family of the order Lamiales. The family is characterized by bisexual flowers with tubular corollas (fused petals) that are bilaterally symmetrical (two-lips) and have four stamens in most, two of which are usually shorter.[MeSH]

Cross-References

ID SourceID
PubMed CID23642602
CHEMBL ID400178
MeSH IDM0515581

Synonyms (3)

Synonym
CHEMBL400178
8-hydroxyserrulat-14-en-19-oic acid
(5r,8s)-4-hydroxy-5-methyl-8-[(2s)-6-methylhept-5-en-2-yl]-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (68)

Assay IDTitleYearJournalArticle
AID1273944Antibiofilm activity against Staphylococcus aureus ATCC 35556 assessed as inhibition of 24 hrs pre-established biofilm formation at 0.064 umol/well after 20 hrs by safranin staining-based method2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273962Induction of apoptosis in C57Bl/6 mouse BMDM cells assessed as early apoptotic cells at 2.5 uM by annexin V-FITC/DAPI staining-based flow cytometric analysis (Rvb = 0.49%)2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273983Increase in IL-1beta production in C57Bl/6 mouse BMDM cells at 2.5 to 80 uM pretreated for 1 hr prior to ATP-stimulation by ELISA2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273930Antibacterial activity against Escherichia coli ATCC 25922 at 658 uM incubated overnight by broth microdilution method2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273982Inhibition of IL-6 production in C57Bl/6 mouse BMDM cells at 10 uM pretreated prior to LPS-stimulation measured on day 7 by ELISA2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273985Increase in IL-1beta production in C57Bl/6 mouse BMDM cells at 20 uM pretreated for 1 hr prior to ATP-stimulation by ELISA2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273955Antibiofilm activity against Staphylococcus epidermidis ATCC 35984 assessed as 12 hrs pre-established supernatant viable cell count at 0.08 umol/mesh after 20 hrs by safranin staining-based UV-visible spectroscopic analysis using compound impregnated in p2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273952Antibiofilm activity against Staphylococcus epidermidis ATCC 35984 assessed as 12 hrs pre-established supernatant viable cell count at 0.01 umol/mesh after 20 hrs by safranin staining-based UV-visible spectroscopic analysis using compound impregnated in p2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273940Antibiofilm activity against Staphylococcus epidermidis ATCC 35984 assessed as inhibition of 12 hrs pre-established biofilm formation at 0.064 umol/well after 20 hrs by visible spectrometric analysis2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273932Antibiofilm activity against Staphylococcus epidermidis ATCC 35984 assessed as inhibition of 12 hrs pre-established biofilm formation at 0.064 umol/well after 20 hrs by safranin staining-based method2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273977Induction of apoptosis in C57Bl/6 mouse BMDM cells assessed as viable cells at 160 uM by annexin V-FITC/DAPI staining-based flow cytometric analysis (Rvb = 46.7%)2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273929Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 at 658 uM incubated overnight by broth microdilution method2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273938Antibiofilm activity against Staphylococcus epidermidis ATCC 35984 assessed as reduction in 12 hrs pre-established biofilm viable cell count after 20 hrs (Rvb = 1.2 x 10'10 CFU/ml)2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID311368Antimicrobial activity against Staphylococcus aureus ATCC 29213 by broth microdilution method2007Journal of natural products, Sep, Volume: 70, Issue:9
Antimicrobial compounds from the Australian desert plant Eremophila neglecta.
AID311373Antimicrobial activity against Salmonella Typhimurium ATCC 13311 at 621.5 uM by broth microdilution method2007Journal of natural products, Sep, Volume: 70, Issue:9
Antimicrobial compounds from the Australian desert plant Eremophila neglecta.
AID1273948Antibiofilm activity against Staphylococcus epidermidis ATCC 35984 assessed as 12 hrs pre-established biofilm viable cell count at 0.01 umol/mesh after 20 hrs by safranin staining-based UV-visible spectroscopic analysis using compound impregnated in polyp2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273956Antibiofilm activity against Staphylococcus epidermidis ATCC 35984 assessed as 12 hrs pre-established supernatant viable cell count at 0.16 umol/mesh after 20 hrs by safranin staining-based UV-visible spectroscopic analysis using compound impregnated in p2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273965Induction of apoptosis in C57Bl/6 mouse BMDM cells assessed as viable cells at 20 uM by annexin V-FITC/DAPI staining-based flow cytometric analysis (Rvb = 46.7%)2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273976Induction of apoptosis in C57Bl/6 mouse BMDM cells assessed as late apoptotic cells at 160 uM by annexin V-FITC/DAPI staining-based flow cytometric analysis (Rvb = 28.4%)2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID311370Antimicrobial activity against Streptococcus pneumoniae ATCC 49619 by broth microdilution method2007Journal of natural products, Sep, Volume: 70, Issue:9
Antimicrobial compounds from the Australian desert plant Eremophila neglecta.
AID1273941Antibiofilm activity against Staphylococcus epidermidis ATCC 35984 assessed as inhibition of 24 hrs pre-established biofilm formation at 0.064 umol/well after 20 hrs by visible spectrometric analysis2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273936Antibiofilm activity against Staphylococcus epidermidis ATCC 35984 assessed as 12 hrs pre-established biofilm viable cell count after 20 hrs (Rvb = 1.2 x 10'10 CFU/ml)2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273926Antibacterial activity against Staphylococcus aureus ATCC 29213 incubated overnight by broth microdilution method2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273958Cytotoxicity against C57Bl/6 mouse BMDM cells assessed as cell viability at <=80 uM after 72 hrs by MTS assay2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID311371Antimicrobial activity against Streptococcus pyogenes ATCC 10389 by broth microdilution method2007Journal of natural products, Sep, Volume: 70, Issue:9
Antimicrobial compounds from the Australian desert plant Eremophila neglecta.
AID1273954Antibiofilm activity against Staphylococcus epidermidis ATCC 35984 assessed as 12 hrs pre-established supernatant viable cell count at 0.04 umol/mesh after 20 hrs by safranin staining-based UV-visible spectroscopic analysis using compound impregnated in p2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273925Antibacterial activity against Staphylococcus aureus ATCC 25923 incubated overnight by broth microdilution method2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273942Antibiofilm activity against Staphylococcus epidermidis ATCC 35984 assessed as induction of loosely attached live and dead bacteria in 12 hrs pre-established biofilm at 0.064 umol/well after 20 hrs by fluorescence staining-based confocal microscopic analy2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273980Inhibition of IL-6 production in C57Bl/6 mouse BMDM cells at 2.5 to 80 uM pretreated prior to LPS-stimulation measured on day 7 by ELISA2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273939Antibiofilm activity against Staphylococcus epidermidis ATCC 35984 assessed as reduction in 24 hrs pre-established biofilm viable cell count after 20 hrs (Rvb = 1.4 x 10'10 +/- 2.6 x 10'9 CFU/ml)2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273972Induction of apoptosis in C57Bl/6 mouse BMDM cells assessed as late apoptotic cells at 80 uM by annexin V-FITC/DAPI staining-based flow cytometric analysis (Rvb = 28.4%)2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273931Antibiofilm activity against Staphylococcus epidermidis ATCC 35984 assessed as inhibition of 3 to 6 hrs pre-established biofilm formation at 0.064 umol/well after 20 hrs by safranin staining-based method2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273928Antibacterial activity against Staphylococcus aureus ATCC 35556 incubated overnight by broth microdilution method2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273971Induction of apoptosis in C57Bl/6 mouse BMDM cells assessed as dead cells at 80 uM by annexin V-FITC/DAPI staining-based flow cytometric analysis (Rvb = 24.4%)2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID311369Antimicrobial activity against Staphylococcus aureus ATCC 25923 by broth microdilution method2007Journal of natural products, Sep, Volume: 70, Issue:9
Antimicrobial compounds from the Australian desert plant Eremophila neglecta.
AID1273937Antibiofilm activity against Staphylococcus epidermidis ATCC 35984 assessed as 24 hrs pre-established biofilm viable cell count after 20 hrs (Rvb = 1.4 x 10'10 +/- 2.6 x 10'9 CFU/ml)2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273957Antibiofilm activity against Staphylococcus epidermidis ATCC 35984 assessed as reduction in 12 hrs pre-established biofilm viable cell count at 0.16 umol after 20 hrs relative to control2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273964Induction of apoptosis in C57Bl/6 mouse BMDM cells assessed as late apoptotic cells at 20 uM by annexin V-FITC/DAPI staining-based flow cytometric analysis (Rvb = 28.4%)2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273969Induction of apoptosis in C57Bl/6 mouse BMDM cells assessed as viable cells at 40 uM by annexin V-FITC/DAPI staining-based flow cytometric analysis (Rvb = 46.7%)2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273933Antibiofilm activity against Staphylococcus epidermidis ATCC 35984 assessed as inhibition of 24 hrs pre-established biofilm formation at 0.064 umol/well after 20 hrs by safranin staining-based method2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID311374Antimicrobial activity against Pseudomonas aeruginosa ATCC 27853 at 621.5 uM by broth microdilution method2007Journal of natural products, Sep, Volume: 70, Issue:9
Antimicrobial compounds from the Australian desert plant Eremophila neglecta.
AID1273973Induction of apoptosis in C57Bl/6 mouse BMDM cells assessed as viable cells at 80 uM by annexin V-FITC/DAPI staining-based flow cytometric analysis (Rvb = 46.7%)2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273963Induction of apoptosis in C57Bl/6 mouse BMDM cells assessed as dead cells at 20 uM by annexin V-FITC/DAPI staining-based flow cytometric analysis (Rvb = 24.4%)2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273934Antibiofilm activity against Staphylococcus epidermidis ATCC 35984 assessed as 3 hrs pre-established biofilm viable cell count after 20 hrs (Rvb = 1 x 10'10 CFU/ml)2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273959Induction of apoptosis in C57Bl/6 mouse BMDM cells assessed as dead cells at 2.5 uM by annexin V-FITC/DAPI staining-based flow cytometric analysis (Rvb = 24.4%)2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273950Antibiofilm activity against Staphylococcus epidermidis ATCC 35984 assessed as 12 hrs pre-established biofilm viable cell count at 0.04 umol/mesh after 20 hrs by safranin staining-based UV-visible spectroscopic analysis using compound impregnated in polyp2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273953Antibiofilm activity against Staphylococcus epidermidis ATCC 35984 assessed as 12 hrs pre-established supernatant viable cell count at 0.02 umol/mesh after 20 hrs by safranin staining-based UV-visible spectroscopic analysis using compound impregnated in p2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273960Induction of apoptosis in C57Bl/6 mouse BMDM cells assessed as late apoptotic cells at 2.5 uM by annexin V-FITC/DAPI staining-based flow cytometric analysis (Rvb = 28.4%)2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273945Antibiofilm activity against Staphylococcus epidermidis ATCC 35984 assessed as 12 hrs pre-established biofilm viable cell count at 0.08 umol/mesh after 20 hrs by safranin staining-based UV-visible spectroscopic analysis using compound impregnated in polyp2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273978Induction of apoptosis in C57Bl/6 mouse BMDM cells assessed as early apoptotic cells at 160 uM by annexin V-FITC/DAPI staining-based flow cytometric analysis (Rvb = 0.49%)2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273947Antibiofilm activity against Staphylococcus epidermidis ATCC 35984 assessed as inhibition of 12 hrs pre-established biofilm formation at 0.16 umol after 20 hrs by safranin staining-based UV-visible spectroscopic analysis using compound impregnated in poly2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273951Antibiofilm activity against Staphylococcus epidermidis ATCC 35984 assessed as 12 hrs pre-established biofilm viable cell count at 0.16 umol/mesh after 20 hrs by safranin staining-based UV-visible spectroscopic analysis using compound impregnated in polyp2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273949Antibiofilm activity against Staphylococcus epidermidis ATCC 35984 assessed as 12 hrs pre-established biofilm viable cell count at 0.02 umol/mesh after 20 hrs by safranin staining-based UV-visible spectroscopic analysis using compound impregnated in polyp2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273967Induction of apoptosis in C57Bl/6 mouse BMDM cells assessed as dead cells at 40 uM by annexin V-FITC/DAPI staining-based flow cytometric analysis (Rvb = 24.4%)2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273961Induction of apoptosis in C57Bl/6 mouse BMDM cells assessed as viable cells at 2.5 uM by annexin V-FITC/DAPI staining-based flow cytometric analysis (Rvb = 46.7%)2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273979Inhibition of TNFalpha production in C57Bl/6 mouse BMDM cells at 40 to 80 uM pretreated prior to LPS-stimulation measured on day 7 by ELISA2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273970Induction of apoptosis in C57Bl/6 mouse BMDM cells assessed as early apoptotic cells at 40 uM by annexin V-FITC/DAPI staining-based flow cytometric analysis (Rvb = 0.49%)2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273981Inhibition of IL-6 production in C57Bl/6 mouse BMDM cells at 5 uM pretreated prior to LPS-stimulation measured on day 7 by ELISA2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273968Induction of apoptosis in C57Bl/6 mouse BMDM cells assessed as late apoptotic cells at 40 uM by annexin V-FITC/DAPI staining-based flow cytometric analysis (Rvb = 28.4%)2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273975Induction of apoptosis in C57Bl/6 mouse BMDM cells assessed as dead cells at 160 uM by annexin V-FITC/DAPI staining-based flow cytometric analysis (Rvb = 24.4%)2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273989Inhibition of IL10 production in C57Bl/6 mouse BMDM cells by ELISA2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273927Antibacterial activity against Staphylococcus epidermidis ATCC 35984 incubated overnight by broth microdilution method2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273966Induction of apoptosis in C57Bl/6 mouse BMDM cells assessed as early apoptotic cells at 20 uM by annexin V-FITC/DAPI staining-based flow cytometric analysis (Rvb = 0.49%)2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273946Antibiofilm activity against Staphylococcus epidermidis ATCC 35984 assessed as inhibition of 12 hrs pre-established biofilm formation after 20 hrs by safranin staining-based UV-visible spectroscopic analysis using compound impregnated in polypropylene mes2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273974Induction of apoptosis in C57Bl/6 mouse BMDM cells assessed as early apoptotic cells at 80 uM by annexin V-FITC/DAPI staining-based flow cytometric analysis (Rvb = 0.49%)2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID311372Antimicrobial activity against Escherichia coli ATCC 25922 at 621.5 uM by broth microdilution method2007Journal of natural products, Sep, Volume: 70, Issue:9
Antimicrobial compounds from the Australian desert plant Eremophila neglecta.
AID1273984Decrease in IL-1beta production in C57Bl/6 mouse BMDM cells at 2.5 to 80 uM pretreated for 1 hr prior to ATP-stimulation by ELISA2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
AID1273935Antibiofilm activity against Staphylococcus epidermidis ATCC 35984 assessed as 6 hrs pre-established biofilm viable cell count after 20 hrs (Rvb = 8.3 x 10'9 CFU/ml)2015Journal of natural products, Dec-24, Volume: 78, Issue:12
Serrulatane Diterpenoid from Eremophila neglecta Exhibits Bacterial Biofilm Dispersion and Inhibits Release of Pro-inflammatory Cytokines from Activated Macrophages.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.84

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.84 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.63 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.84)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
vancomycin
Vancomycin: Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.. vancomycin : A complex glycopeptide from Streptomyces orientalis. It inhibits a specific step in the synthesis of the peptidoglycan layer in the Gram-positive bacteria Staphylococcus aureus and Clostridium difficile.		2.0310glycopeptideantibacterial drug;
antimicrobial agent;
bacterial metabolite
hydrocortisone hemisuccinate
hydrocortisone succinate : A derivative of succinic acid in which one of the carboxy groups is esterified by the C-21 hydroxy group of cortisol (hydrocortisone).		2.1110dicarboxylic acid monoester;
hemisuccinate;
tertiary alpha-hydroxy ketone
levofloxacin
Levofloxacin: The L-isomer of Ofloxacin.. levofloxacin : An optically active form of ofloxacin having (S)-configuration; an inhibitor of bacterial topoisomerase IV and DNA gyrase.		2.11109-fluoro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid;
fluoroquinolone antibiotic;
quinolone antibiotic		antibacterial drug;
DNA synthesis inhibitor;
EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor;
topoisomerase IV inhibitor
chlorhexidine
Chlorhexidine: A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.. chlorhexidine : A bisbiguanide compound with a structure consisting of two (p-chlorophenyl)guanide units linked by a hexamethylene bridge.		2.1110biguanides;
monochlorobenzenes		antibacterial agent;
antiinfective agent
gentamicin sulfate
[no description available]		2.0310
ConditionIndicatedRelationship StrengthStudiesTrials
Infections, Staphylococcal
[description not available]		02.520
Staphylococcal Infections
Infections with bacteria of the genus STAPHYLOCOCCUS.		02.520
Infections, Prosthesis-Related
[description not available]		02.0810