8-hydroxyoctanoic acid profile

8-Hydroxyoctanoic acid (8-HOA) is a naturally occurring fatty acid found in various organisms, including bacteria and plants. It is a key intermediate in the biosynthesis of the antibiotic octadeca-2,4-dienoic acid. 8-HOA has been shown to exhibit antimicrobial activity, inhibiting the growth of certain bacteria. Research on 8-HOA focuses on its role in microbial metabolism, its potential as an antimicrobial agent, and its potential applications in bioremediation and industrial processes. 8-HOA is synthesized via the oxidation of octanoic acid, typically using enzymes from various microorganisms.'

8-hydroxyoctanoic acid: has been identified in the urine of children with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

8-hydroxyoctanoic acid : An omega-hydroxy fatty acid that is caprylic acid in which one of the hydrogens of the terminal methyl group is replaced by a hydroxy group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	69820
CHEBI ID	79162
SCHEMBL ID	80794
MeSH ID	M0221862

Synonym
BB 0261076
octanoic acid, 8-hydroxy-
8-hydroxyoctanoic acid
8-hydroxy caprylic acid
LMFA01050023
8-hydroxy-octanoic acid
8-hydroxyoctanoic acid, 98% (t)
764-89-6
A838722
8-hydroxyoctanoate
AKOS006223694
92348-62-4
FT-0632907
S10749
SCHEMBL80794
CHEBI:79162
8-hydroxycaprylic acid
omega-hydroxyoctanoic acid
omega-hydroxycaprylic acid
DTXSID40227234
mfcd00792446
8-hydroxyoctanoicacid
DS-6067
Q27148223
SY022019
AMY5109
octanoic acid,8-hydroxy-
CS-0187285

Class	Description
straight-chain fatty acid	Any fatty acid whose skeletal carbon atoms form an unbranched open chain.
omega-hydroxy-medium-chain fatty acid	A omega-hydroxy-fatty acid with a chain length ranging from C6 to C12.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (12.50)	18.2507
2000's	0 (0.00)	29.6817
2010's	5 (62.50)	24.3611
2020's	2 (25.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
glycine [no description available]	1.98	1	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical
fluorouracil Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.. 5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.	2.85	3	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic
isocaproic acid isocaproic acid: RN given refers to parent cpd. isocaproic acid : A methyl-branched fatty acid that is pentanoic acid with a methyl group substituent at position 4. It is a metabolite of 20 alpha-hydroxycholesterol	1.98	1	branched-chain saturated fatty acid; medium-chain fatty acid; methyl-branched fatty acid	human metabolite
deoxycytidine [no description available]	2.13	1	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
3-hydroxyoctanoic acid 3-hydroxyoctanoic acid : An 8-carbon, beta-hydroxy fatty acid which may be a marker for primary defects of beta-hydroxy fatty acid metabolism. Repeating unit of poly(3-hydroxyoctanoic acid), a biopolymer used by numerous bacterial species as carbon and energy reserves.	2.15	1	3-hydroxy fatty acid; 3-hydroxy monocarboxylic acid; medium-chain fatty acid
gemcitabine gemcitabine : A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer.	2.13	1	organofluorine compound; pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent; antiviral drug; DNA synthesis inhibitor; EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor; environmental contaminant; immunosuppressive agent; photosensitizing agent; prodrug; radiosensitizing agent; xenobiotic
10-hydroxycapric acid 10-hydroxycapric acid : A 10-carbon, omega-hydroxy fatty acid, shown to be the preferred hydroxylation product (together with the 9-OH isomer) of capric acid in biosystems, and used as a standard in lipid assays; reported to have cytotoxic effects.	2.31	1	omega-hydroxy-medium-chain fatty acid; straight-chain saturated fatty acid
caprylates Caprylates: Derivatives of caprylic acid. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain a carboxy terminated eight carbon aliphatic structure.. octanoate : A straight-chain saturated fatty acid anion that is the conjugate base of octanoic acid (caprylic acid); believed to block adipogenesis.	3.61	8	fatty acid anion 8:0; straight-chain saturated fatty acid anion	human metabolite; Saccharomyces cerevisiae metabolite
arachidonic acid icosa-5,8,11,14-tetraenoic acid : Any icosatetraenoic acid with the double bonds at positions 5, 8, 11 and 14.. arachidonate : A long-chain fatty acid anion resulting from the removal of a proton from the carboxy group of arachidonic acid.	2.13	1	icosa-5,8,11,14-tetraenoic acid; long-chain fatty acid; omega-6 fatty acid	Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; human metabolite; mouse metabolite
8,11,14-eicosatrienoic acid 8,11,14-Eicosatrienoic Acid: A 20-carbon-chain fatty acid, unsaturated at positions 8, 11, and 14. It differs from arachidonic acid, 5,8,11,14-eicosatetraenoic acid, only at position 5.. all-cis-icosa-8,11,14-trienoic acid : An icosatrienoic acid having three cis double bonds at positions 8, 11 and 14.	3.06	4	fatty acid 20:3; long-chain fatty acid	fungal metabolite; human metabolite; nutraceutical

Condition	Relationship Strength	Studies
Cancer of Lung [description not available]	2.31	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.31	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.31	1
Dry Eye [description not available]	2.31	1
Dry Eye Syndromes Corneal and conjunctival dryness due to deficient tear production, predominantly in menopausal and post-menopausal women. Filamentary keratitis or erosion of the conjunctival and corneal epithelium may be caused by these disorders. Sensation of the presence of a foreign body in the eye and burning of the eyes may occur.	2.31	1
Breast Cancer [description not available]	2.17	1
Breast Neoplasms Tumors or cancer of the human BREAST.	2.17	1
Cancer of Colon [description not available]	2.55	2
Metastase [description not available]	2.17	1
Colonic Neoplasms Tumors or cancer of the COLON.	2.55	2
Neoplasm Metastasis The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	2.17	1
Cancer of Pancreas [description not available]	2.13	1
Pancreatic Neoplasms Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).	2.13	1

8-hydroxyoctanoic acid

Description

Cross-References

Synonyms (28)

Drug Classes (2)

Research

Studies (8)

Market Indicators

Research Demand Index: 21.57

Study Types